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Receptors involved in the nervous system regulation of polyamine metabolism in rat salivary glands

Ekström, J.; Månsson, Bengt LU ; Tobin, G; Nilsson, B O LU and Rosengren, Elsa (1989) In Acta Physiol.Scand 135(3). p.255-61
Abstract

Polyamines are important for protein synthesis and tissue growth. In rat salivary glands, the activity of ornithine decarboxylase (ODC), the enzyme catalysing the formation of putrescine, and the content of putrescine, spermidine, spermine and N1-acetylspermidine were assayed after parasympathetic or sympathetic nerve stimulation in the presence of various autonomic receptor blockers. Increases in ODC activity occurred on activation of non-adrenergic and non-cholinergic receptors in response to parasympathetic nerve stimulation and on activation of alpha(alpha 1)- as well as of beta(beta 1)-adrenoceptors in response to sympathetic nerve stimulation. Moreover, in parotid glands, a beta(beta 1)-adrenoceptor-mediated inverse pathway for... (More)

Polyamines are important for protein synthesis and tissue growth. In rat salivary glands, the activity of ornithine decarboxylase (ODC), the enzyme catalysing the formation of putrescine, and the content of putrescine, spermidine, spermine and N1-acetylspermidine were assayed after parasympathetic or sympathetic nerve stimulation in the presence of various autonomic receptor blockers. Increases in ODC activity occurred on activation of non-adrenergic and non-cholinergic receptors in response to parasympathetic nerve stimulation and on activation of alpha(alpha 1)- as well as of beta(beta 1)-adrenoceptors in response to sympathetic nerve stimulation. Moreover, in parotid glands, a beta(beta 1)-adrenoceptor-mediated inverse pathway for putrescine formation seemed to exist: from spermidine via N1-acetylspermidine.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Atropine, Dihydroergotamine, Male, Ornithine Decarboxylase, Parasympathetic Nervous System, Phentolamine, Propranolol, Putrescine, Rats, Rats, Inbred Strains, Salivary Glands, Spermidine, Spermine, Sympathetic Nervous System, Yohimbine
in
Acta Physiol.Scand
volume
135
issue
3
pages
255 - 61
publisher
Wiley-Blackwell
external identifiers
  • Scopus:0024563979
ISSN
0001-6772
DOI
10.1111/j.1748-1716.1989.tb08575.x
language
English
LU publication?
yes
id
775d7e9f-32b9-4b8b-becb-0ba3e9f08c05
date added to LUP
2016-06-17 16:50:10
date last changed
2016-08-04 15:22:23
@misc{775d7e9f-32b9-4b8b-becb-0ba3e9f08c05,
  abstract     = {<p>Polyamines are important for protein synthesis and tissue growth. In rat salivary glands, the activity of ornithine decarboxylase (ODC), the enzyme catalysing the formation of putrescine, and the content of putrescine, spermidine, spermine and N1-acetylspermidine were assayed after parasympathetic or sympathetic nerve stimulation in the presence of various autonomic receptor blockers. Increases in ODC activity occurred on activation of non-adrenergic and non-cholinergic receptors in response to parasympathetic nerve stimulation and on activation of alpha(alpha 1)- as well as of beta(beta 1)-adrenoceptors in response to sympathetic nerve stimulation. Moreover, in parotid glands, a beta(beta 1)-adrenoceptor-mediated inverse pathway for putrescine formation seemed to exist: from spermidine via N1-acetylspermidine.</p>},
  author       = {Ekström, J. and Månsson, Bengt and Tobin, G and Nilsson, B O and Rosengren, Elsa},
  issn         = {0001-6772},
  keyword      = {Animals,Atropine,Dihydroergotamine,Male,Ornithine Decarboxylase,Parasympathetic Nervous System,Phentolamine,Propranolol,Putrescine,Rats,Rats, Inbred Strains,Salivary Glands,Spermidine,Spermine,Sympathetic Nervous System,Yohimbine},
  language     = {eng},
  number       = {3},
  pages        = {255--61},
  publisher    = {ARRAY(0xa6c62e0)},
  series       = {Acta Physiol.Scand},
  title        = {Receptors involved in the nervous system regulation of polyamine metabolism in rat salivary glands},
  url          = {http://dx.doi.org/10.1111/j.1748-1716.1989.tb08575.x},
  volume       = {135},
  year         = {1989},
}