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Novel pharmacologic strategies in the treatment of experimental traumatic brain injury : 1998

McIntosh, Tracy K.; Juhler, Marianne and Wieloch, Tadeusz LU (1998) In Journal of Neurotrauma 15(10). p.731-769
Abstract

The mechanisms underlying secondary or delayed cell death following traumatic brain injury are poorly understood. Recent evidence from experimental models suggests that widespread neuronal loss is progressive and continues in selectively vulnerable brain regions for months to years after the initial insult. The mechanisms underlying delayed cell death are believed to result, in part, from the release or activation of endogenous 'autodestructive' pathways induced by the traumatic injury. The development of sophisticated neurochemical, histopathological and molecular techniques to study animal models of TBI have enabled researchers to begin to explore the cellular and genomic pathways that mediate cell damage and death. This new knowledge... (More)

The mechanisms underlying secondary or delayed cell death following traumatic brain injury are poorly understood. Recent evidence from experimental models suggests that widespread neuronal loss is progressive and continues in selectively vulnerable brain regions for months to years after the initial insult. The mechanisms underlying delayed cell death are believed to result, in part, from the release or activation of endogenous 'autodestructive' pathways induced by the traumatic injury. The development of sophisticated neurochemical, histopathological and molecular techniques to study animal models of TBI have enabled researchers to begin to explore the cellular and genomic pathways that mediate cell damage and death. This new knowledge has stimulated the development of novel therapeutic agents designed to modify gene expression, synthesis, release, receptor or functional activity of these pathological factors with subsequent attenuation of cellular damage and improvement in behavioral function. This article represents a compendium of recent studies suggesting that modification of post-traumatic neurochemical and cellular events with targeted pharmacotherapy can promote functional recovery following traumatic injury to the central nervous system.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pharmacotherapy, Traumatic brain injury
in
Journal of Neurotrauma
volume
15
issue
10
pages
39 pages
publisher
Mary Ann Liebert, Inc.
external identifiers
  • Scopus:0031766138
ISSN
0897-7151
language
English
LU publication?
yes
id
7baf59e4-529a-4a20-acf1-37e13210a779
date added to LUP
2016-10-05 16:06:46
date last changed
2016-11-03 14:33:40
@misc{7baf59e4-529a-4a20-acf1-37e13210a779,
  abstract     = {<p>The mechanisms underlying secondary or delayed cell death following traumatic brain injury are poorly understood. Recent evidence from experimental models suggests that widespread neuronal loss is progressive and continues in selectively vulnerable brain regions for months to years after the initial insult. The mechanisms underlying delayed cell death are believed to result, in part, from the release or activation of endogenous 'autodestructive' pathways induced by the traumatic injury. The development of sophisticated neurochemical, histopathological and molecular techniques to study animal models of TBI have enabled researchers to begin to explore the cellular and genomic pathways that mediate cell damage and death. This new knowledge has stimulated the development of novel therapeutic agents designed to modify gene expression, synthesis, release, receptor or functional activity of these pathological factors with subsequent attenuation of cellular damage and improvement in behavioral function. This article represents a compendium of recent studies suggesting that modification of post-traumatic neurochemical and cellular events with targeted pharmacotherapy can promote functional recovery following traumatic injury to the central nervous system.</p>},
  author       = {McIntosh, Tracy K. and Juhler, Marianne and Wieloch, Tadeusz},
  issn         = {0897-7151},
  keyword      = {Pharmacotherapy,Traumatic brain injury},
  language     = {eng},
  number       = {10},
  pages        = {731--769},
  publisher    = {ARRAY(0x7bb56c0)},
  series       = {Journal of Neurotrauma},
  title        = {Novel pharmacologic strategies in the treatment of experimental traumatic brain injury : 1998},
  volume       = {15},
  year         = {1998},
}