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Bronchocarcinogenic Properties of Welding and Thermal Spraying Fumes Containing Chromium in the Rat

Berg, N O; Berlin, M; Bohgard, Mats LU ; Rudell, B; Schütz, A and Warfvinge, Karin LU (1987) In American Journal of Industrial Medicine 11. p.39-54
Abstract
The possible bronchocarcinogenic effects of fumes released during the shielded metal arc welding of stainless steel and the thermal spraying of chromium oxide (Cr2O3) have been studied on the rat. The fume particles were shown to contain tri- and hexavalent chromium in soluble and low soluble forms; they were collected and implanted as pellets in the bronchi of groups of 100 rats by the method of Laskin et al. A negative control group of 100 rats was included, as well as positive controls receiving pellets containing benz(a)pyrene. The experiment was continued for 34 months; no differences of biological significance were noted between the growth rates, survival times, and terminal organ weights of the test and negative control groups. At... (More)
The possible bronchocarcinogenic effects of fumes released during the shielded metal arc welding of stainless steel and the thermal spraying of chromium oxide (Cr2O3) have been studied on the rat. The fume particles were shown to contain tri- and hexavalent chromium in soluble and low soluble forms; they were collected and implanted as pellets in the bronchi of groups of 100 rats by the method of Laskin et al. A negative control group of 100 rats was included, as well as positive controls receiving pellets containing benz(a)pyrene. The experiment was continued for 34 months; no differences of biological significance were noted between the growth rates, survival times, and terminal organ weights of the test and negative control groups. At autopsy, the macroscopic and microscopic appearance of the organs in the three groups, including the local reaction to the implanted pellet, were similar. No precancerous changes were observed at the implantation sites; one rat, who received a pellet containing welding fumes, showed squamous cell carcinoma remote from the implantation site and not associated with the bronchus. It had the appearance of a metastasis. All three benz(a)pyrene control rats developed cancer at the implantation site. The occupational health implications of these findings are discussed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
thermal spraying, aerosol, welding, industrial hygiene
in
American Journal of Industrial Medicine
volume
11
pages
39 - 54
publisher
John Wiley & Sons
external identifiers
  • Scopus:0023107054
ISSN
0271-3586
DOI
10.1002/ajim.4700110105
language
English
LU publication?
yes
id
d4076171-9312-45b3-b0d1-3aa09ffad229 (old id 801754)
alternative location
http://www3.interscience.wiley.com/cgi-bin/abstract/114054405/ABSTRACT?CRETRY=1&SRETRY=0
date added to LUP
2008-02-07 09:37:16
date last changed
2016-04-16 12:02:16
@misc{d4076171-9312-45b3-b0d1-3aa09ffad229,
  abstract     = {The possible bronchocarcinogenic effects of fumes released during the shielded metal arc welding of stainless steel and the thermal spraying of chromium oxide (Cr2O3) have been studied on the rat. The fume particles were shown to contain tri- and hexavalent chromium in soluble and low soluble forms; they were collected and implanted as pellets in the bronchi of groups of 100 rats by the method of Laskin et al. A negative control group of 100 rats was included, as well as positive controls receiving pellets containing benz(a)pyrene. The experiment was continued for 34 months; no differences of biological significance were noted between the growth rates, survival times, and terminal organ weights of the test and negative control groups. At autopsy, the macroscopic and microscopic appearance of the organs in the three groups, including the local reaction to the implanted pellet, were similar. No precancerous changes were observed at the implantation sites; one rat, who received a pellet containing welding fumes, showed squamous cell carcinoma remote from the implantation site and not associated with the bronchus. It had the appearance of a metastasis. All three benz(a)pyrene control rats developed cancer at the implantation site. The occupational health implications of these findings are discussed.},
  author       = {Berg, N O and Berlin, M and Bohgard, Mats and Rudell, B and Schütz, A and Warfvinge, Karin},
  issn         = {0271-3586},
  keyword      = {thermal spraying,aerosol,welding,industrial hygiene},
  language     = {eng},
  pages        = {39--54},
  publisher    = {ARRAY(0xa3e98a8)},
  series       = {American Journal of Industrial Medicine},
  title        = {Bronchocarcinogenic Properties of Welding and Thermal Spraying Fumes Containing Chromium in the Rat},
  url          = {http://dx.doi.org/10.1002/ajim.4700110105},
  volume       = {11},
  year         = {1987},
}