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Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer.

Elebro, Jacob LU ; Ben Dror, Liv LU ; Heby, Margareta LU ; Nodin, Björn LU ; Jirström, Karin LU and Eberhard, Jakob LU (2015) In Acta oncologica (Stockholm, Sweden) 55(3). p.96-286
Abstract
Putative biomarkers of gemcitabine response have been extensively studied in pancreatic cancer, but less so in other types of periampullary adenocarcinoma. The most studied biomarker is human equilibrative nucleoside transporter 1 (hENT1), and the activating enzyme deoxycytidine kinase (dCK) has also been linked to treatment response. The RNA-binding protein human antigen R (HuR) has been demonstrated to confer increased dCK levels in vitro and to predict gemcitabine response in vivo. Here, we investigated the prognostic impact of hENT1, dCK and HuR in pancreatobiliary (PB) and intestinal (I) type periampullary cancers, respectively.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta oncologica (Stockholm, Sweden)
volume
55
issue
3
pages
96 - 286
publisher
Taylor & Francis
external identifiers
  • PMID:26362587
  • Scopus:84941248673
  • WOS:000371249500005
ISSN
1651-226X
DOI
10.3109/0284186X.2015.1075663
language
English
LU publication?
yes
id
3c0991e8-6c2d-4184-b552-7d3f94b1e086 (old id 8042509)
date added to LUP
2015-10-04 14:10:37
date last changed
2016-10-13 04:31:05
@misc{3c0991e8-6c2d-4184-b552-7d3f94b1e086,
  abstract     = {Putative biomarkers of gemcitabine response have been extensively studied in pancreatic cancer, but less so in other types of periampullary adenocarcinoma. The most studied biomarker is human equilibrative nucleoside transporter 1 (hENT1), and the activating enzyme deoxycytidine kinase (dCK) has also been linked to treatment response. The RNA-binding protein human antigen R (HuR) has been demonstrated to confer increased dCK levels in vitro and to predict gemcitabine response in vivo. Here, we investigated the prognostic impact of hENT1, dCK and HuR in pancreatobiliary (PB) and intestinal (I) type periampullary cancers, respectively.},
  author       = {Elebro, Jacob and Ben Dror, Liv and Heby, Margareta and Nodin, Björn and Jirström, Karin and Eberhard, Jakob},
  issn         = {1651-226X},
  language     = {eng},
  number       = {3},
  pages        = {96--286},
  publisher    = {ARRAY(0x897c3c0)},
  series       = {Acta oncologica (Stockholm, Sweden)},
  title        = {Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer.},
  url          = {http://dx.doi.org/10.3109/0284186X.2015.1075663},
  volume       = {55},
  year         = {2015},
}