A new equation to estimate temperaturecorrected PaCO2 from PET CO2 during exercise in normoxia and hypoxia.
(2015) In Scandinavian Journal of Medicine & Science in Sports 26(9). p.10451051 Abstract
 Endtidal PCO2 (PET CO2 ) has been used to estimate arterial pressure CO2 (Pa CO2 ). However, the influence of blood temperature on the Pa CO2 has not been taken into account. Moreover, there is no equation validated to predict Pa CO2 during exercise in severe acute hypoxia. To develop a new equation to predict temperaturecorrected Pa CO2 values during exercise in normoxia and severe acute hypoxia, 11 volunteers (21.2 ± 2.1 years) performed incremental exercise to exhaustion in normoxia (Nox, PI O2 : 143 mmHg) and hypoxia (Hyp, PI O2 : 73 mmHg), while arterial blood gases and temperature (ABT) were simultaneously measured together with endtidal PCO2 (PET CO2 ). The Jones et al. equation tended to underestimate the temperature corrected... (More)
 Endtidal PCO2 (PET CO2 ) has been used to estimate arterial pressure CO2 (Pa CO2 ). However, the influence of blood temperature on the Pa CO2 has not been taken into account. Moreover, there is no equation validated to predict Pa CO2 during exercise in severe acute hypoxia. To develop a new equation to predict temperaturecorrected Pa CO2 values during exercise in normoxia and severe acute hypoxia, 11 volunteers (21.2 ± 2.1 years) performed incremental exercise to exhaustion in normoxia (Nox, PI O2 : 143 mmHg) and hypoxia (Hyp, PI O2 : 73 mmHg), while arterial blood gases and temperature (ABT) were simultaneously measured together with endtidal PCO2 (PET CO2 ). The Jones et al. equation tended to underestimate the temperature corrected (tc) Pa CO2 during exercise in hypoxia, with greater deviation the lower the Pa CO2 tc (r = 0.39, P < 0.05). The new equation has been developed using a randomeffects regression analysis model, which allows predicting Pa CO2 tc both in normoxia and hypoxia: Pa CO2 tc = 8.607 + 0.716 × PET CO2 [R(2) = 0.91; intercept SE = 1.022 (P < 0.001) and slope SE = 0.027 (P < 0.001)]. This equation may prove useful in noninvasive studies of brain hemodynamics, where an accurate estimation of Pa CO2 is needed to calculate the endtidaltoarterial PCO2 difference, which can be used as an index of pulmonary gas exchange efficiency. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/record/8043871
 author
 González Henríquez, J J; LosaReyna, J; TorresPeralta, R; Rådegran, Göran ^{LU} ; Koskolou, M and Calbet, J A L
 organization
 publishing date
 20150827
 type
 Contribution to journal
 publication status
 published
 subject
 in
 Scandinavian Journal of Medicine & Science in Sports
 volume
 26
 issue
 9
 pages
 1045  1051
 publisher
 WileyBlackwell
 external identifiers

 PMID:26314285
 Scopus:84940880223
 ISSN
 16000838
 DOI
 10.1111/sms.12545
 language
 English
 LU publication?
 yes
 id
 ce0b0c7ee4a64e73968ef193c2d9c42b (old id 8043871)
 date added to LUP
 20151007 21:46:20
 date last changed
 20161013 04:33:52
@misc{ce0b0c7ee4a64e73968ef193c2d9c42b, abstract = {Endtidal PCO2 (PET CO2 ) has been used to estimate arterial pressure CO2 (Pa CO2 ). However, the influence of blood temperature on the Pa CO2 has not been taken into account. Moreover, there is no equation validated to predict Pa CO2 during exercise in severe acute hypoxia. To develop a new equation to predict temperaturecorrected Pa CO2 values during exercise in normoxia and severe acute hypoxia, 11 volunteers (21.2 ± 2.1 years) performed incremental exercise to exhaustion in normoxia (Nox, PI O2 : 143 mmHg) and hypoxia (Hyp, PI O2 : 73 mmHg), while arterial blood gases and temperature (ABT) were simultaneously measured together with endtidal PCO2 (PET CO2 ). The Jones et al. equation tended to underestimate the temperature corrected (tc) Pa CO2 during exercise in hypoxia, with greater deviation the lower the Pa CO2 tc (r = 0.39, P < 0.05). The new equation has been developed using a randomeffects regression analysis model, which allows predicting Pa CO2 tc both in normoxia and hypoxia: Pa CO2 tc = 8.607 + 0.716 × PET CO2 [R(2) = 0.91; intercept SE = 1.022 (P < 0.001) and slope SE = 0.027 (P < 0.001)]. This equation may prove useful in noninvasive studies of brain hemodynamics, where an accurate estimation of Pa CO2 is needed to calculate the endtidaltoarterial PCO2 difference, which can be used as an index of pulmonary gas exchange efficiency.}, author = {González Henríquez, J J and LosaReyna, J and TorresPeralta, R and Rådegran, Göran and Koskolou, M and Calbet, J A L}, issn = {16000838}, language = {eng}, month = {08}, number = {9}, pages = {10451051}, publisher = {ARRAY(0x98fb2a0)}, series = {Scandinavian Journal of Medicine & Science in Sports}, title = {A new equation to estimate temperaturecorrected PaCO2 from PET CO2 during exercise in normoxia and hypoxia.}, url = {http://dx.doi.org/10.1111/sms.12545}, volume = {26}, year = {2015}, }