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Genetic factors influencing the risk of multiple myeloma bone disease.

Johnson, D C; Weinhold, N; Mitchell, J; Chen, B; Stephens, O W; Försti, Asta LU ; Nickel, J; Kaiser, M; Gregory, W A and Cairns, D, et al. (2015) In Leukemia 30. p.883-888
Abstract
A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totalling 3774) which had been radiologically surveyed for MBD. Each patient had been genotyped for ~600 000 SNPs with genotypes for six million common variants imputed using 1000Genomes Project and UK10K as reference. We identified a locus at 8q24.12 for MBD (rs4407910, OPG/TNFRSF11B, odds ratio [OR]=1.38, P=4.09 × 10(-9)) and a promising association at 19q13.43 (rs74676832, OR=1.97, P=9.33 × 10(-7)). Our findings demonstrate that germline variation influences MBD and highlights the importance of... (More)
A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totalling 3774) which had been radiologically surveyed for MBD. Each patient had been genotyped for ~600 000 SNPs with genotypes for six million common variants imputed using 1000Genomes Project and UK10K as reference. We identified a locus at 8q24.12 for MBD (rs4407910, OPG/TNFRSF11B, odds ratio [OR]=1.38, P=4.09 × 10(-9)) and a promising association at 19q13.43 (rs74676832, OR=1.97, P=9.33 × 10(-7)). Our findings demonstrate that germline variation influences MBD and highlights the importance of RANK/RANKL/OPG pathway in MBD development. These findings will contribute to the development of future strategies for prevention of MBD in the early precancerous phases of MM.Leukemia accepted article preview online, 16 December 2015. doi:10.1038/leu.2015.342. (Less)
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Leukemia
volume
30
pages
883 - 888
publisher
Nature Publishing Group
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  • PMID:26669972
  • Scopus:84954533526
  • WOS:000374123100014
ISSN
1476-5551
DOI
10.1038/leu.2015.342
language
English
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yes
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0efbc7fb-c687-4c2a-90bd-01cd095124b5 (old id 8504737)
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http://www.ncbi.nlm.nih.gov/pubmed/26669972?dopt=Abstract
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2016-01-05 19:39:07
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@misc{0efbc7fb-c687-4c2a-90bd-01cd095124b5,
  abstract     = {A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totalling 3774) which had been radiologically surveyed for MBD. Each patient had been genotyped for ~600 000 SNPs with genotypes for six million common variants imputed using 1000Genomes Project and UK10K as reference. We identified a locus at 8q24.12 for MBD (rs4407910, OPG/TNFRSF11B, odds ratio [OR]=1.38, P=4.09 × 10(-9)) and a promising association at 19q13.43 (rs74676832, OR=1.97, P=9.33 × 10(-7)). Our findings demonstrate that germline variation influences MBD and highlights the importance of RANK/RANKL/OPG pathway in MBD development. These findings will contribute to the development of future strategies for prevention of MBD in the early precancerous phases of MM.Leukemia accepted article preview online, 16 December 2015. doi:10.1038/leu.2015.342.},
  author       = {Johnson, D C and Weinhold, N and Mitchell, J and Chen, B and Stephens, O W and Försti, Asta and Nickel, J and Kaiser, M and Gregory, W A and Cairns, D and Jackson, G H and Hoffmann, P and Noethen, M M and Hillengass, J and Bertsch, U and Barlogie, B and Davis, F E and Hemminki, Kari and Goldschmidt, H and Houlston, R S and Morgan, G J},
  issn         = {1476-5551},
  language     = {eng},
  month        = {12},
  pages        = {883--888},
  publisher    = {ARRAY(0x89d8d48)},
  series       = {Leukemia},
  title        = {Genetic factors influencing the risk of multiple myeloma bone disease.},
  url          = {http://dx.doi.org/10.1038/leu.2015.342},
  volume       = {30},
  year         = {2015},
}