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Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients.

Xu, Xiang; Yadav, Nirbhay N; Knutsson, Linda LU ; Hua, Jun; Kalyani, Rita; Hall, Erica; Laterra, John; Blakeley, Jaishri; Strowd, Roy and Pomper, Martin, et al. (2015) In Tomography : a journal for imaging research 1(2). p.105-114
Abstract
Recent animal studies have shown that D-glucose is a potential biodegradable MRI contrast agent for imaging glucose uptake in tumors. Here, we show the first translation of that use of D-glucose to human studies. Chemical exchange saturation transfer (CEST) MRI at a single frequency offset optimized for detection of hydroxyl protons in D-glucose (glucoCEST) was used to image dynamic signal changes in the human brain at 7T during and after infusion of D-glucose. Dynamic glucose-enhanced (DGE) image data from four normal volunteers and three glioma patients showed strong signal enhancement in blood vessels, while the enhancement varied spatially over the tumor. Areas of enhancement differed spatially between DGE and conventional Gd-enhanced... (More)
Recent animal studies have shown that D-glucose is a potential biodegradable MRI contrast agent for imaging glucose uptake in tumors. Here, we show the first translation of that use of D-glucose to human studies. Chemical exchange saturation transfer (CEST) MRI at a single frequency offset optimized for detection of hydroxyl protons in D-glucose (glucoCEST) was used to image dynamic signal changes in the human brain at 7T during and after infusion of D-glucose. Dynamic glucose-enhanced (DGE) image data from four normal volunteers and three glioma patients showed strong signal enhancement in blood vessels, while the enhancement varied spatially over the tumor. Areas of enhancement differed spatially between DGE and conventional Gd-enhanced imaging, suggesting complementary image information content for these two types of agents. In addition, different tumor areas enhanced with D-glucose at different times post-infusion, suggesting a sensitivity to perfusion-related properties such as substrate delivery and blood-brain barrier (BBB) permeability. These preliminary results suggest that DGE MRI is feasible to study glucose uptake in humans, providing a time-dependent set of data that contains information regarding arterial input function (AIF), tissue perfusion, glucose transport across the BBB and cell membrane, and glucose metabolism. (Less)
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published
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Tomography : a journal for imaging research
volume
1
issue
2
pages
105 - 114
external identifiers
  • PMID:26779568
ISSN
2379-1381
DOI
10.18383/j.tom.2015.00175
language
English
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yes
id
9c4571c6-6566-4613-b6db-f26052c10611 (old id 8577201)
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http://www.ncbi.nlm.nih.gov/pubmed/26779568?dopt=Abstract
date added to LUP
2016-02-10 12:02:23
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2016-09-20 03:19:40
@misc{9c4571c6-6566-4613-b6db-f26052c10611,
  abstract     = {Recent animal studies have shown that D-glucose is a potential biodegradable MRI contrast agent for imaging glucose uptake in tumors. Here, we show the first translation of that use of D-glucose to human studies. Chemical exchange saturation transfer (CEST) MRI at a single frequency offset optimized for detection of hydroxyl protons in D-glucose (glucoCEST) was used to image dynamic signal changes in the human brain at 7T during and after infusion of D-glucose. Dynamic glucose-enhanced (DGE) image data from four normal volunteers and three glioma patients showed strong signal enhancement in blood vessels, while the enhancement varied spatially over the tumor. Areas of enhancement differed spatially between DGE and conventional Gd-enhanced imaging, suggesting complementary image information content for these two types of agents. In addition, different tumor areas enhanced with D-glucose at different times post-infusion, suggesting a sensitivity to perfusion-related properties such as substrate delivery and blood-brain barrier (BBB) permeability. These preliminary results suggest that DGE MRI is feasible to study glucose uptake in humans, providing a time-dependent set of data that contains information regarding arterial input function (AIF), tissue perfusion, glucose transport across the BBB and cell membrane, and glucose metabolism.},
  author       = {Xu, Xiang and Yadav, Nirbhay N and Knutsson, Linda and Hua, Jun and Kalyani, Rita and Hall, Erica and Laterra, John and Blakeley, Jaishri and Strowd, Roy and Pomper, Martin and Barker, Peter and Chan, Kannie and Liu, Guanshu and McMahon, Michael T and Stevens, Robert D and van Zijl, Peter C M},
  issn         = {2379-1381},
  language     = {eng},
  number       = {2},
  pages        = {105--114},
  series       = {Tomography : a journal for imaging research},
  title        = {Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients.},
  url          = {http://dx.doi.org/10.18383/j.tom.2015.00175},
  volume       = {1},
  year         = {2015},
}