Advanced

Perfusion assessment with bolus differentiation : a technique applicable to hyperpolarized tracers

Johansson, Edvin LU ; Olsson, L E LU ; Månsson, S LU ; Petersson, J S LU ; Golman, K LU ; Ståhlberg, F LU and Wirestam, R LU (2004) In Magnetic Resonance in Medicine 52(5). p.51-1043
Abstract

A new technique for assessing tissue blood flow using hyperpolarized tracers, based on the fact that the magnetization of a hyperpolarized substance can be destroyed permanently, is described. Assessments of blood flow with this technique are inherently insensitive to arterial delay and dispersion, and allow for quantification of the transit time and dispersion in the arteries that supply the investigated tissue. Renal cortical blood flow was studied in six rabbits using a 13C-labeled compound (2-hydroxyethylacrylate) that was polarized by the parahydrogen-induced polarization (PHIP) technique. The renal cortical blood flow was estimated to be 5.7/5.4 +/- 1.6/1.3 ml/min per milliliter of tissue (mean +/- SD, right/left kidney), and the... (More)

A new technique for assessing tissue blood flow using hyperpolarized tracers, based on the fact that the magnetization of a hyperpolarized substance can be destroyed permanently, is described. Assessments of blood flow with this technique are inherently insensitive to arterial delay and dispersion, and allow for quantification of the transit time and dispersion in the arteries that supply the investigated tissue. Renal cortical blood flow was studied in six rabbits using a 13C-labeled compound (2-hydroxyethylacrylate) that was polarized by the parahydrogen-induced polarization (PHIP) technique. The renal cortical blood flow was estimated to be 5.7/5.4 +/- 1.6/1.3 ml/min per milliliter of tissue (mean +/- SD, right/left kidney), and the mean transit time and dispersion in the renal arteries were determined to be 1.47/1.42 +/- 0.07/0.07 s and 1.78/1.93 +/- 0.40/0.42 s2, respectively.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Algorithms, Animals, Artifacts, Blood Volume, Carbon Isotopes, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Rabbits, Renal Circulation, Statistics, Nonparametric
in
Magnetic Resonance in Medicine
volume
52
issue
5
pages
9 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:7544220591
ISSN
0740-3194
DOI
10.1002/mrm.20247
language
English
LU publication?
yes
id
87a83c41-9e88-4c64-84bd-828c7276efec
date added to LUP
2016-08-16 13:58:51
date last changed
2016-10-30 04:49:14
@misc{87a83c41-9e88-4c64-84bd-828c7276efec,
  abstract     = {<p>A new technique for assessing tissue blood flow using hyperpolarized tracers, based on the fact that the magnetization of a hyperpolarized substance can be destroyed permanently, is described. Assessments of blood flow with this technique are inherently insensitive to arterial delay and dispersion, and allow for quantification of the transit time and dispersion in the arteries that supply the investigated tissue. Renal cortical blood flow was studied in six rabbits using a 13C-labeled compound (2-hydroxyethylacrylate) that was polarized by the parahydrogen-induced polarization (PHIP) technique. The renal cortical blood flow was estimated to be 5.7/5.4 +/- 1.6/1.3 ml/min per milliliter of tissue (mean +/- SD, right/left kidney), and the mean transit time and dispersion in the renal arteries were determined to be 1.47/1.42 +/- 0.07/0.07 s and 1.78/1.93 +/- 0.40/0.42 s2, respectively.</p>},
  author       = {Johansson, Edvin and Olsson, L E and Månsson, S and Petersson, J S and Golman, K and Ståhlberg, F and Wirestam, R},
  issn         = {0740-3194},
  keyword      = {Algorithms,Animals,Artifacts,Blood Volume,Carbon Isotopes,Image Processing, Computer-Assisted,Magnetic Resonance Imaging,Male,Rabbits,Renal Circulation,Statistics, Nonparametric},
  language     = {eng},
  number       = {5},
  pages        = {51--1043},
  publisher    = {ARRAY(0x7e94728)},
  series       = {Magnetic Resonance in Medicine},
  title        = {Perfusion assessment with bolus differentiation : a technique applicable to hyperpolarized tracers},
  url          = {http://dx.doi.org/10.1002/mrm.20247},
  volume       = {52},
  year         = {2004},
}