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Prior Adjuvant Tamoxifen Treatment in Breast Cancer Is Linked to Increased AIB1 and HER2 Expression in Metachronous Contralateral Breast Cancer.

Alkner, Sara LU ; Bendahl, Pär-Ola LU ; Ehinger, Anna LU ; Lövgren, Kristina LU ; Rydén, Lisa LU and Fernö, Mårten LU (2016) In PLoS One 11(3).
Abstract
The estrogen receptor coactivator Amplified in Breast Cancer 1 (AIB1) has been associated with an improved response to adjuvant tamoxifen in breast cancer, but also with endocrine treatment resistance. We hereby use metachronous contralateral breast cancer (CBC) developed despite prior adjuvant tamoxifen for the first tumor as an "in vivo"-model for tamoxifen resistance. AIB1-expression in the presumable resistant (CBC after prior tamoxifen) and naïve setting (CBC without prior tamoxifen) is compared and correlated to prognosis after CBC.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS One
volume
11
issue
3
publisher
Public Library of Science
external identifiers
  • PMID:26959415
  • WOS:000371992300089
  • Scopus:84962510005
ISSN
1932-6203
DOI
10.1371/journal.pone.0150977
language
English
LU publication?
yes
id
0ae7472c-2886-48a3-b47a-722813f185ef (old id 8852876)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26959415?dopt=Abstract
date added to LUP
2016-03-17 08:54:51
date last changed
2016-11-14 12:43:47
@misc{0ae7472c-2886-48a3-b47a-722813f185ef,
  abstract     = {The estrogen receptor coactivator Amplified in Breast Cancer 1 (AIB1) has been associated with an improved response to adjuvant tamoxifen in breast cancer, but also with endocrine treatment resistance. We hereby use metachronous contralateral breast cancer (CBC) developed despite prior adjuvant tamoxifen for the first tumor as an "in vivo"-model for tamoxifen resistance. AIB1-expression in the presumable resistant (CBC after prior tamoxifen) and naïve setting (CBC without prior tamoxifen) is compared and correlated to prognosis after CBC.},
  author       = {Alkner, Sara and Bendahl, Pär-Ola and Ehinger, Anna and Lövgren, Kristina and Rydén, Lisa and Fernö, Mårten},
  issn         = {1932-6203},
  language     = {eng},
  number       = {3},
  publisher    = {ARRAY(0xa2bd248)},
  series       = {PLoS One},
  title        = {Prior Adjuvant Tamoxifen Treatment in Breast Cancer Is Linked to Increased AIB1 and HER2 Expression in Metachronous Contralateral Breast Cancer.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0150977},
  volume       = {11},
  year         = {2016},
}