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Developmental programming : State-of-the-science and future directions: Summary from a Pennington Biomedical symposium

Sutton, Elizabeth F; Gilmore, L Anne; Dunger, David B; Heijmans, Bas T; Hivert, Marie-France; Ling, Charlotte LU ; Martinez, J Alfredo; Ozanne, Susan E; Simmons, Rebecca A and Szyf, Moshe, et al. (2016) In Obesity
Abstract

OBJECTIVE: On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies, and human clinical trials, (ii) the state-of-the-science of epigenetic-based research, and (iii) considerations for future studies.

RESULTS: This symposium provided a comprehensive assessment of the state of the scientific field and identified research gaps and opportunities for future research in order to understand the mechanisms contributing to the... (More)

OBJECTIVE: On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies, and human clinical trials, (ii) the state-of-the-science of epigenetic-based research, and (iii) considerations for future studies.

RESULTS: This symposium provided a comprehensive assessment of the state of the scientific field and identified research gaps and opportunities for future research in order to understand the mechanisms contributing to the developmental programming of health and disease.

CONCLUSIONS: Identifying the mechanisms which cause or contribute to developmental programming of future generations will be invaluable to the scientific and medical community. The ability to intervene during critical periods of prenatal and early postnatal life to promote lifelong health is the ultimate goal. Considerations for future research including the use of animal models, the study design in human cohorts with considerations about the timing of the intrauterine exposure, and the resulting tissue-specific epigenetic signature were extensively discussed and are presented in this meeting summary.

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organization
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Contribution to journal
publication status
epub
subject
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Obesity
publisher
Nature Publishing Group
external identifiers
  • Scopus:84963517839
ISSN
1930-739X
DOI
10.1002/oby.21487
language
English
LU publication?
yes
id
8a7e1b00-e573-4762-bd64-3156f8676696
date added to LUP
2016-04-26 11:55:45
date last changed
2016-10-27 13:58:32
@misc{8a7e1b00-e573-4762-bd64-3156f8676696,
  abstract     = {<p>OBJECTIVE: On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies, and human clinical trials, (ii) the state-of-the-science of epigenetic-based research, and (iii) considerations for future studies.</p><p>RESULTS: This symposium provided a comprehensive assessment of the state of the scientific field and identified research gaps and opportunities for future research in order to understand the mechanisms contributing to the developmental programming of health and disease.</p><p>CONCLUSIONS: Identifying the mechanisms which cause or contribute to developmental programming of future generations will be invaluable to the scientific and medical community. The ability to intervene during critical periods of prenatal and early postnatal life to promote lifelong health is the ultimate goal. Considerations for future research including the use of animal models, the study design in human cohorts with considerations about the timing of the intrauterine exposure, and the resulting tissue-specific epigenetic signature were extensively discussed and are presented in this meeting summary.</p>},
  author       = {Sutton, Elizabeth F and Gilmore, L Anne and Dunger, David B and Heijmans, Bas T and Hivert, Marie-France and Ling, Charlotte and Martinez, J Alfredo and Ozanne, Susan E and Simmons, Rebecca A and Szyf, Moshe and Waterland, Robert A and Redman, Leanne M and Ravussin, Eric},
  issn         = {1930-739X},
  language     = {eng},
  month        = {04},
  publisher    = {ARRAY(0x86291e8)},
  series       = {Obesity},
  title        = {Developmental programming : State-of-the-science and future directions: Summary from a Pennington Biomedical symposium},
  url          = {http://dx.doi.org/10.1002/oby.21487},
  year         = {2016},
}