Cartilage macromolecules in knee synovial fluid. Markers of the disease course in patients with acute oligoarthritis
(1997) In Annals of the Rheumatic Diseases 56. p.751-753- Abstract
- OBJECTIVE To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms.
METHODS Retrospective follow up of 25 patients identified in a bank of knee joint synovial fluids collected consecutively from patients presenting with knee joint synovitis and symptoms from at most three additional joints and in whom no diagnosis could be established at presentation.
RESULTS The 10 patients who developed chronic joint symptoms were characterised... (More) - OBJECTIVE To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms.
METHODS Retrospective follow up of 25 patients identified in a bank of knee joint synovial fluids collected consecutively from patients presenting with knee joint synovitis and symptoms from at most three additional joints and in whom no diagnosis could be established at presentation.
RESULTS The 10 patients who developed chronic joint symptoms were characterised by lower knee joint synovial fluid concentrations of aggrecan as well as lower aggrecan/COMP ratios (p<0.001) than the 15 patients who had a transient arthritis. No other clinical or laboratory differences between the groups were apparent at the time of presentation.
CONCLUSIONS The synovial fluid content of aggrecan is a potential tool in acute arthritis for distinguishing patients with a benign disease course from those who will develop a chronic joint disorder. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8c17267c-1ce2-4a3b-a5ab-110e2faf1dbe
- author
- Saxne, Tore LU and Lindqvist, Elisabet LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- knee synovial fluid, oligoarthritis
- in
- Annals of the Rheumatic Diseases
- volume
- 56
- pages
- 751 - 753
- publisher
- BMJ Publishing Group
- ISSN
- 1468-2060
- language
- English
- LU publication?
- yes
- id
- 8c17267c-1ce2-4a3b-a5ab-110e2faf1dbe
- date added to LUP
- 2016-05-07 12:38:12
- date last changed
- 2021-10-22 02:17:37
@article{8c17267c-1ce2-4a3b-a5ab-110e2faf1dbe, abstract = {{OBJECTIVE To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms. <br> <br> METHODS Retrospective follow up of 25 patients identified in a bank of knee joint synovial fluids collected consecutively from patients presenting with knee joint synovitis and symptoms from at most three additional joints and in whom no diagnosis could be established at presentation. <br> <br> RESULTS The 10 patients who developed chronic joint symptoms were characterised by lower knee joint synovial fluid concentrations of aggrecan as well as lower aggrecan/COMP ratios (p<0.001) than the 15 patients who had a transient arthritis. No other clinical or laboratory differences between the groups were apparent at the time of presentation. <br> <br> CONCLUSIONS The synovial fluid content of aggrecan is a potential tool in acute arthritis for distinguishing patients with a benign disease course from those who will develop a chronic joint disorder.}}, author = {{Saxne, Tore and Lindqvist, Elisabet}}, issn = {{1468-2060}}, keywords = {{knee synovial fluid; oligoarthritis}}, language = {{eng}}, pages = {{751--753}}, publisher = {{BMJ Publishing Group}}, series = {{Annals of the Rheumatic Diseases}}, title = {{Cartilage macromolecules in knee synovial fluid. Markers of the disease course in patients with acute oligoarthritis}}, volume = {{56}}, year = {{1997}}, }