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Cartilage macromolecules in knee synovial fluid. Markers of the disease course in patients with acute oligoarthritis

Saxne, Tore LU and Lindqvist, Elisabet LU (1997) In Annals of the Rheumatic Diseases 56. p.751-753
Abstract
OBJECTIVE To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms.

METHODS Retrospective follow up of 25 patients identified in a bank of knee joint synovial fluids collected consecutively from patients presenting with knee joint synovitis and symptoms from at most three additional joints and in whom no diagnosis could be established at presentation.

RESULTS The 10 patients who developed chronic joint symptoms were characterised... (More)
OBJECTIVE To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms.

METHODS Retrospective follow up of 25 patients identified in a bank of knee joint synovial fluids collected consecutively from patients presenting with knee joint synovitis and symptoms from at most three additional joints and in whom no diagnosis could be established at presentation.

RESULTS The 10 patients who developed chronic joint symptoms were characterised by lower knee joint synovial fluid concentrations of aggrecan as well as lower aggrecan/COMP ratios (p<0.001) than the 15 patients who had a transient arthritis. No other clinical or laboratory differences between the groups were apparent at the time of presentation.

CONCLUSIONS The synovial fluid content of aggrecan is a potential tool in acute arthritis for distinguishing patients with a benign disease course from those who will develop a chronic joint disorder. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
knee synovial fluid, oligoarthritis
in
Annals of the Rheumatic Diseases
volume
56
pages
751 - 753
publisher
British Medical Association
ISSN
1468-2060
language
English
LU publication?
yes
id
8c17267c-1ce2-4a3b-a5ab-110e2faf1dbe
date added to LUP
2016-05-07 12:38:12
date last changed
2016-05-26 13:49:29
@misc{8c17267c-1ce2-4a3b-a5ab-110e2faf1dbe,
  abstract     = {OBJECTIVE To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms. <br>
<br>
METHODS Retrospective follow up of 25 patients identified in a bank of knee joint synovial fluids collected consecutively from patients presenting with knee joint synovitis and symptoms from at most three additional joints and in whom no diagnosis could be established at presentation. <br>
<br>
RESULTS The 10 patients who developed chronic joint symptoms were characterised by lower knee joint synovial fluid concentrations of aggrecan as well as lower aggrecan/COMP ratios (p&lt;0.001) than the 15 patients who had a transient arthritis. No other clinical or laboratory differences between the groups were apparent at the time of presentation. <br>
<br>
CONCLUSIONS The synovial fluid content of aggrecan is a potential tool in acute arthritis for distinguishing patients with a benign disease course from those who will develop a chronic joint disorder. },
  author       = {Saxne, Tore and Lindqvist, Elisabet},
  issn         = {1468-2060},
  keyword      = {knee synovial fluid,oligoarthritis},
  language     = {eng},
  pages        = {751--753},
  publisher    = {ARRAY(0x7e53dd8)},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Cartilage macromolecules in knee synovial fluid. Markers of the disease course in patients with acute oligoarthritis},
  volume       = {56},
  year         = {1997},
}