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Unconditional two-locus nonparametric linkage analysis

Ängquist, Lars LU ; Anevski, Dragi LU and Luthman, Holger LU (2005) In Preprint without journal information
Abstract
We discuss different aspects of unconditional two-locus nonparametric linkage (NPL) analysis with special emphasis on gene-gene interaction. We interpret this as identical-by-descent (IBD) sharing correlation between two disease loci both having marginal effect. We relate this to the concept of two-locus NPL score functions, the possible importance of using a composite rather than a simple null hypothesis and the corresponding calculation of statistical power. Moreover, we define several classes of score functions and give multiple suggestions on how to incorporate a composite null hypothesis into the analysis. The least favourable two-locus IBD-distribution is discussed, resulting in an upper bound of the two-locus p-value.
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author
organization
publishing date
type
Contribution to journal
publication status
unpublished
subject
in
Preprint without journal information
issue
2005:28
publisher
Manne Siegbahn Institute
ISSN
0348-7911
language
English
LU publication?
yes
id
aa7b630b-0a69-418f-9ee2-cbdc39c3491f (old id 930229)
date added to LUP
2008-01-15 15:07:30
date last changed
2016-04-16 06:20:37
@misc{aa7b630b-0a69-418f-9ee2-cbdc39c3491f,
  abstract     = {We discuss different aspects of unconditional two-locus nonparametric linkage (NPL) analysis with special emphasis on gene-gene interaction. We interpret this as identical-by-descent (IBD) sharing correlation between two disease loci both having marginal effect. We relate this to the concept of two-locus NPL score functions, the possible importance of using a composite rather than a simple null hypothesis and the corresponding calculation of statistical power. Moreover, we define several classes of score functions and give multiple suggestions on how to incorporate a composite null hypothesis into the analysis. The least favourable two-locus IBD-distribution is discussed, resulting in an upper bound of the two-locus p-value.},
  author       = {Ängquist, Lars and Anevski, Dragi and Luthman, Holger},
  issn         = {0348-7911},
  language     = {eng},
  number       = {2005:28},
  publisher    = {ARRAY(0x988fee0)},
  series       = {Preprint without journal information},
  title        = {Unconditional two-locus nonparametric linkage analysis},
  year         = {2005},
}