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Estrogen receptor genes in gastropods : phylogenetic divergence and gene expression responses to a synthetic estrogen

Hultin, Cecilia L. LU ; Hallgren, Per LU and Hansson, Maria C. LU (2016) In Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 189. p.17-21
Abstract

Endocrine disrupting chemicals (EDCs) have the potential to affect development and reproduction in gastropods. However, one is today lacking basic understanding of the Molluscan endocrine system and one can therefore not fully explain these EDC-induced affects. Furthermore, only a few genes that potentially may be connected to the endocrine system have been sequenced in gastropods. An example is the estrogen receptor gene (er) that have been identified in a restricted number of freshwater and marine gastropods. Here, we have identified a new partial coding sequence of an estrogen receptor gene (er) in the European common heterobranch Radix balthica. The following phylogenetic analysis divided the ers of heterobranchs and ceanogastropods... (More)

Endocrine disrupting chemicals (EDCs) have the potential to affect development and reproduction in gastropods. However, one is today lacking basic understanding of the Molluscan endocrine system and one can therefore not fully explain these EDC-induced affects. Furthermore, only a few genes that potentially may be connected to the endocrine system have been sequenced in gastropods. An example is the estrogen receptor gene (er) that have been identified in a restricted number of freshwater and marine gastropods. Here, we have identified a new partial coding sequence of an estrogen receptor gene (er) in the European common heterobranch Radix balthica. The following phylogenetic analysis divided the ers of heterobranchs and ceanogastropods in two branches. Furthermore, exposure to the synthetic estrogen 17α-ethinylestradiol (EE2) showed that exposure could significantly affect er expression level in the heterobranch R. balthica. This paper is the first that phylogenetically compares gastropods' er, basal er expression profiles, and transcriptional estrogenic responses in gastropods from two different evolutionary groups.

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organization
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Contribution to journal
publication status
published
subject
keywords
17α-Ethinylestradiol, Estrogen receptor, Gastropods, Phylogenetic analysis
in
Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
volume
189
pages
5 pages
publisher
Elsevier
external identifiers
  • Scopus:84978705087
ISSN
1532-0456
DOI
10.1016/j.cbpc.2016.07.002
language
English
LU publication?
yes
id
9c061075-f16e-41dd-b126-60daa55c2c07
date added to LUP
2016-10-13 09:34:59
date last changed
2016-10-14 03:00:06
@misc{9c061075-f16e-41dd-b126-60daa55c2c07,
  abstract     = {<p>Endocrine disrupting chemicals (EDCs) have the potential to affect development and reproduction in gastropods. However, one is today lacking basic understanding of the Molluscan endocrine system and one can therefore not fully explain these EDC-induced affects. Furthermore, only a few genes that potentially may be connected to the endocrine system have been sequenced in gastropods. An example is the estrogen receptor gene (er) that have been identified in a restricted number of freshwater and marine gastropods. Here, we have identified a new partial coding sequence of an estrogen receptor gene (er) in the European common heterobranch Radix balthica. The following phylogenetic analysis divided the ers of heterobranchs and ceanogastropods in two branches. Furthermore, exposure to the synthetic estrogen 17α-ethinylestradiol (EE2) showed that exposure could significantly affect er expression level in the heterobranch R. balthica. This paper is the first that phylogenetically compares gastropods' er, basal er expression profiles, and transcriptional estrogenic responses in gastropods from two different evolutionary groups.</p>},
  author       = {Hultin, Cecilia L. and Hallgren, Per and Hansson, Maria C.},
  issn         = {1532-0456},
  keyword      = {17α-Ethinylestradiol,Estrogen receptor,Gastropods,Phylogenetic analysis},
  language     = {eng},
  month        = {11},
  pages        = {17--21},
  publisher    = {ARRAY(0xa8f2768)},
  series       = {Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology},
  title        = {Estrogen receptor genes in gastropods : phylogenetic divergence and gene expression responses to a synthetic estrogen},
  url          = {http://dx.doi.org/10.1016/j.cbpc.2016.07.002},
  volume       = {189},
  year         = {2016},
}