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The immunopathogenesis of immune thrombocytopenia : T cells still take center-stage

Semple, John W LU and Provan, Drew (2012) In Current Opinion in Hematology 19(5). p.62-357
Abstract

PURPOSE OF REVIEW: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder in which T and B cells recognize platelet antigens and initiate antiplatelet destructive mechanisms such as peripheral Fc receptor-mediated phagocytosis in the spleen or megakaryocyte destruction/inhibition within the bone marrow. The purpose of this review is to report on the ITP pathophysiology literature published from January 2011 to early in 2012.

RECENT FINDINGS: The underlying stimulus of platelet autoimmunity is not known; however, in 2011, as in previous years, there has been a significant contribution of published studies addressing the pathophysiology of ITP. At least half of the 2011 ITP pathophysiology literature was associated with... (More)

PURPOSE OF REVIEW: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder in which T and B cells recognize platelet antigens and initiate antiplatelet destructive mechanisms such as peripheral Fc receptor-mediated phagocytosis in the spleen or megakaryocyte destruction/inhibition within the bone marrow. The purpose of this review is to report on the ITP pathophysiology literature published from January 2011 to early in 2012.

RECENT FINDINGS: The underlying stimulus of platelet autoimmunity is not known; however, in 2011, as in previous years, there has been a significant contribution of published studies addressing the pathophysiology of ITP. At least half of the 2011 ITP pathophysiology literature was associated with T-cell dysregulation particularly with respect to T-helper 17 cell and related cytokine and genetic studies. There were also studies related to B-cell responses, human spleen cells and the potential role of oxidative stress in ITP. With respect to therapeutic research, the mechanisms of action of intravenous gammaglobulin relating to Fc inhibitory receptors and sialylation have been challenged.

SUMMARY: The overall landscape of pathophysiological research into ITP still is overwhelmed by studies on abnormal T-cell responses and these studies are beginning to clarify the underlying immune mechanisms that are responsible for the disorder.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Administration, Intravenous, Autoimmunity, B-Lymphocytes, Humans, Immunity, Cellular, Oxidative Stress, Purpura, Thrombocytopenic, Idiopathic, T-Lymphocytes, gamma-Globulins, Journal Article, Review
in
Current Opinion in Hematology
volume
19
issue
5
pages
6 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • Scopus:84865435670
ISSN
1531-7048
DOI
10.1097/MOH.0b013e3283567541
language
English
LU publication?
no
id
a2dd39b5-5ede-4030-bdcc-e7511ac8207f
date added to LUP
2016-09-23 12:03:35
date last changed
2016-10-30 04:50:07
@misc{a2dd39b5-5ede-4030-bdcc-e7511ac8207f,
  abstract     = {<p>PURPOSE OF REVIEW: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder in which T and B cells recognize platelet antigens and initiate antiplatelet destructive mechanisms such as peripheral Fc receptor-mediated phagocytosis in the spleen or megakaryocyte destruction/inhibition within the bone marrow. The purpose of this review is to report on the ITP pathophysiology literature published from January 2011 to early in 2012.</p><p>RECENT FINDINGS: The underlying stimulus of platelet autoimmunity is not known; however, in 2011, as in previous years, there has been a significant contribution of published studies addressing the pathophysiology of ITP. At least half of the 2011 ITP pathophysiology literature was associated with T-cell dysregulation particularly with respect to T-helper 17 cell and related cytokine and genetic studies. There were also studies related to B-cell responses, human spleen cells and the potential role of oxidative stress in ITP. With respect to therapeutic research, the mechanisms of action of intravenous gammaglobulin relating to Fc inhibitory receptors and sialylation have been challenged.</p><p>SUMMARY: The overall landscape of pathophysiological research into ITP still is overwhelmed by studies on abnormal T-cell responses and these studies are beginning to clarify the underlying immune mechanisms that are responsible for the disorder.</p>},
  author       = {Semple, John W and Provan, Drew},
  issn         = {1531-7048},
  keyword      = {Administration, Intravenous,Autoimmunity,B-Lymphocytes,Humans,Immunity, Cellular,Oxidative Stress,Purpura, Thrombocytopenic, Idiopathic,T-Lymphocytes,gamma-Globulins,Journal Article,Review},
  language     = {eng},
  number       = {5},
  pages        = {62--357},
  publisher    = {ARRAY(0xb6f6f48)},
  series       = {Current Opinion in Hematology},
  title        = {The immunopathogenesis of immune thrombocytopenia : T cells still take center-stage},
  url          = {http://dx.doi.org/10.1097/MOH.0b013e3283567541},
  volume       = {19},
  year         = {2012},
}