A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia
(2004) In Cancer Genetics and Cytogenetics 148(1). p.9-77- Abstract
A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.
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https://lup.lub.lu.se/record/a5b9b18b-3234-4bd5-82ff-6c8a40177a2e
- author
- Lazarevic, Vladimir Lj LU ; Tomin, Dragica ; Jankovic, Gradimir M ; Antic, Darko ; Dencic, Marija ; Gotic, Mirjana and Boskovic, Darinka
- publishing date
- 2004-01-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Aged, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 2, Humans, Leukemia, Myeloid, Acute, Male, Thrombocythemia, Essential, Translocation, Genetic
- in
- Cancer Genetics and Cytogenetics
- volume
- 148
- issue
- 1
- pages
- 3 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0347511684
- pmid:14697645
- ISSN
- 0165-4608
- DOI
- 10.1016/S0165-4608(03)00215-2
- language
- English
- LU publication?
- no
- id
- a5b9b18b-3234-4bd5-82ff-6c8a40177a2e
- date added to LUP
- 2016-05-24 17:23:53
- date last changed
- 2024-08-18 03:05:42
@article{a5b9b18b-3234-4bd5-82ff-6c8a40177a2e, abstract = {{<p>A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.</p>}}, author = {{Lazarevic, Vladimir Lj and Tomin, Dragica and Jankovic, Gradimir M and Antic, Darko and Dencic, Marija and Gotic, Mirjana and Boskovic, Darinka}}, issn = {{0165-4608}}, keywords = {{Aged; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 2; Humans; Leukemia, Myeloid, Acute; Male; Thrombocythemia, Essential; Translocation, Genetic}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{9--77}}, publisher = {{Elsevier}}, series = {{Cancer Genetics and Cytogenetics}}, title = {{A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia}}, url = {{http://dx.doi.org/10.1016/S0165-4608(03)00215-2}}, doi = {{10.1016/S0165-4608(03)00215-2}}, volume = {{148}}, year = {{2004}}, }