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Effects of renal failure on skeletal muscle

Clyne, N. LU ; Esbjornsson, M.; Jansson, E.; Jogestrand, T.; Lins, L. E. and Pehrsson, S. K. (1993) In Nephron 63(4). p.395-399
Abstract

In this cross-sectional study, we examined biopsies from the vastus lateralis muscle of 13 predialytic uremic men (mean age 46 ± 8 years). Their average glomerular filtration rate was 14 ± 7 ml/min x 1.73 m2 and their maximal exercise capacity, measured by standardized exercise test on a bicycle ergometer, was 184 ± 45 W (94% of the expected norm). The proportion of type I fibers (type I%) in the uremic group was similar to that of the reference group (42 ± 11 vs. 41 ± 8% NS). The proportion of type IIA fibers (type IIA%) in the uremic group was higher than in the reference group (44±10 compared to 35±9%, p2, NS). Type IIA and type I IB fiber areas tended to be smaller than those of the reference group (type IIA fiber area:... (More)

In this cross-sectional study, we examined biopsies from the vastus lateralis muscle of 13 predialytic uremic men (mean age 46 ± 8 years). Their average glomerular filtration rate was 14 ± 7 ml/min x 1.73 m2 and their maximal exercise capacity, measured by standardized exercise test on a bicycle ergometer, was 184 ± 45 W (94% of the expected norm). The proportion of type I fibers (type I%) in the uremic group was similar to that of the reference group (42 ± 11 vs. 41 ± 8% NS). The proportion of type IIA fibers (type IIA%) in the uremic group was higher than in the reference group (44±10 compared to 35±9%, p2, NS). Type IIA and type I IB fiber areas tended to be smaller than those of the reference group (type IIA fiber area: 4,515 ± 929 vs. 5,213 ± 1,288 μm2, NS; type IIB fiber area: 3,953 ± 1,066 vs. 4,406 ± 1,582 μm2, NS) with a type IIA area/type I area ratio which was significantly lower than in the reference group. Citrate synthase activity was 0.48 ± 0.08 μkat/g in the uremic group and 0.50 ± 0.08 μkat/g in the reference group, NS. Phosphofructokinase activity was 1.2 ± 0.5 μkat/g in the uremic group and 1.1 ± 0.3 μkat/g in the reference group, NS. Maximal exercise capacity showed a positive correlation to type 1% (r=0.71, p

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Maximal exercise capacity, Mitochondrial enzymes, Moderate uremia, Muscle fiber composition
in
Nephron
volume
63
issue
4
pages
5 pages
publisher
Karger
external identifiers
  • Scopus:0027535338
ISSN
0028-2766
language
English
LU publication?
no
id
a5f105a9-495d-4de4-bcde-f8f03b2c21c1
date added to LUP
2016-08-30 22:03:52
date last changed
2016-09-16 15:09:49
@misc{a5f105a9-495d-4de4-bcde-f8f03b2c21c1,
  abstract     = {<p>In this cross-sectional study, we examined biopsies from the vastus lateralis muscle of 13 predialytic uremic men (mean age 46 ± 8 years). Their average glomerular filtration rate was 14 ± 7 ml/min x 1.73 m<sup>2</sup> and their maximal exercise capacity, measured by standardized exercise test on a bicycle ergometer, was 184 ± 45 W (94% of the expected norm). The proportion of type I fibers (type I%) in the uremic group was similar to that of the reference group (42 ± 11 vs. 41 ± 8% NS). The proportion of type IIA fibers (type IIA%) in the uremic group was higher than in the reference group (44±10 compared to 35±9%, p2, NS). Type IIA and type I IB fiber areas tended to be smaller than those of the reference group (type IIA fiber area: 4,515 ± 929 vs. 5,213 ± 1,288 μm<sup>2</sup>, NS; type IIB fiber area: 3,953 ± 1,066 vs. 4,406 ± 1,582 μm<sup>2</sup>, NS) with a type IIA area/type I area ratio which was significantly lower than in the reference group. Citrate synthase activity was 0.48 ± 0.08 μkat/g in the uremic group and 0.50 ± 0.08 μkat/g in the reference group, NS. Phosphofructokinase activity was 1.2 ± 0.5 μkat/g in the uremic group and 1.1 ± 0.3 μkat/g in the reference group, NS. Maximal exercise capacity showed a positive correlation to type 1% (r=0.71, p</p>},
  author       = {Clyne, N. and Esbjornsson, M. and Jansson, E. and Jogestrand, T. and Lins, L. E. and Pehrsson, S. K.},
  issn         = {0028-2766},
  keyword      = {Maximal exercise capacity,Mitochondrial enzymes,Moderate uremia,Muscle fiber composition},
  language     = {eng},
  number       = {4},
  pages        = {395--399},
  publisher    = {ARRAY(0xb0deac0)},
  series       = {Nephron},
  title        = {Effects of renal failure on skeletal muscle},
  volume       = {63},
  year         = {1993},
}