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Long-term pattern of HIV-1 RNA load in perinatally infected children

Navér, Lars; Ehrnst, Anneka; Belfrage, Erik; Sönnerborg, Anders; Lidin-Janson, Gunilla; Christensson, Bertil LU ; Ljung, Rolf LU and Bohlin, Ann-Britt (1999) In Scandinavian Journal of Infectious Diseases 31(4). p.337-343
Abstract
The objective of this study was to describe the natural history of HIV-1 RNA load in vertically HIV-1-infected children. HIV-1 RNA in 156 plasma or serum samples (1-14, median 4 from each child) from 32 vertically HIV-1-infected children was detected with the NASBA® technique (Organon Teknika, The Netherlands). Twenty-one children were prospectively followed from birth, and 11 were identified and included at the age of 7-89 (median 61) months. The highest numbers of HIV-1 RNA copies were seen at 1.5-3 months of age. A quadratic curve model showed a reduction of HIV-1 RNA with increasing age up to approximately 8 years, and thereafter increasing numbers, p(age) = 0.002, p(age2) = 0.008, This pattern was not typical for individual children... (More)
The objective of this study was to describe the natural history of HIV-1 RNA load in vertically HIV-1-infected children. HIV-1 RNA in 156 plasma or serum samples (1-14, median 4 from each child) from 32 vertically HIV-1-infected children was detected with the NASBA® technique (Organon Teknika, The Netherlands). Twenty-one children were prospectively followed from birth, and 11 were identified and included at the age of 7-89 (median 61) months. The highest numbers of HIV-1 RNA copies were seen at 1.5-3 months of age. A quadratic curve model showed a reduction of HIV-1 RNA with increasing age up to approximately 8 years, and thereafter increasing numbers, p(age) = 0.002, p(age2) = 0.008, This pattern was not typical for individual children in whom a great variation in HIV-1 RNA numbers was seen over time. The interval from birth to the first HIV-1 RNA peak ranged from 1.5 months to more than 2 years. The HIV-1 RNA levels remained relatively high and fluctuating over the years in symptomatic as well as in long-term symptomatic children. This makes HIV-1 RNA determination in children more difficult to use than in adults, as the only tool for prediction of disease progression and for initiation of therapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antivirus agent, virus RNA, zidovudine, age, article, child, clinical article, disease course, human, Human immunodeficiency virus 1, infant, newborn, perinatal infection, prediction, treatment planning, vertical transmission, virus load
in
Scandinavian Journal of Infectious Diseases
volume
31
issue
4
pages
7 pages
publisher
Informa Healthcare
external identifiers
  • Scopus:0032846805
ISSN
1651-1980
DOI
10.1080/00365549950163743
language
English
LU publication?
yes
id
b643e99d-7c28-457e-8386-1e20a69b8bec
date added to LUP
2016-11-25 14:37:20
date last changed
2016-11-30 10:05:17
@misc{b643e99d-7c28-457e-8386-1e20a69b8bec,
  abstract     = {The objective of this study was to describe the natural history of HIV-1 RNA load in vertically HIV-1-infected children. HIV-1 RNA in 156 plasma or serum samples (1-14, median 4 from each child) from 32 vertically HIV-1-infected children was detected with the NASBA® technique (Organon Teknika, The Netherlands). Twenty-one children were prospectively followed from birth, and 11 were identified and included at the age of 7-89 (median 61) months. The highest numbers of HIV-1 RNA copies were seen at 1.5-3 months of age. A quadratic curve model showed a reduction of HIV-1 RNA with increasing age up to approximately 8 years, and thereafter increasing numbers, p(age) = 0.002, p(age2) = 0.008, This pattern was not typical for individual children in whom a great variation in HIV-1 RNA numbers was seen over time. The interval from birth to the first HIV-1 RNA peak ranged from 1.5 months to more than 2 years. The HIV-1 RNA levels remained relatively high and fluctuating over the years in symptomatic as well as in long-term symptomatic children. This makes HIV-1 RNA determination in children more difficult to use than in adults, as the only tool for prediction of disease progression and for initiation of therapy.},
  author       = {Navér, Lars and Ehrnst, Anneka and Belfrage, Erik and Sönnerborg, Anders and Lidin-Janson, Gunilla and Christensson, Bertil and Ljung, Rolf and Bohlin, Ann-Britt},
  issn         = {1651-1980},
  keyword      = {antivirus agent,virus RNA,zidovudine,age,article,child,clinical article,disease course,human,Human immunodeficiency virus 1,infant,newborn,perinatal infection,prediction,treatment planning,vertical transmission,virus load},
  language     = {eng},
  month        = {11},
  number       = {4},
  pages        = {337--343},
  publisher    = {ARRAY(0xabfaf78)},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Long-term pattern of HIV-1 RNA load in perinatally infected children},
  url          = {http://dx.doi.org/10.1080/00365549950163743},
  volume       = {31},
  year         = {1999},
}