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A dynamic role of the medial temporal lobe during retrieval of declarative memory in man

Petersson, K M; Elfgren, C LU and Ingvar, M (1997) In NeuroImage 6(1). p.1-11
Abstract

Understanding the role of the medial temporal lobe (MTL) in learning and memory is an important problem in cognitive neuroscience. Memory and learning processes that depend on the function of the MTL and related diencephalic structures (e.g., the anterior and mediodorsal thalamic nuclei) are defined as declarative. We have studied the MTL activity as indicated by regional cerebral blood flow with positron emission tomography and statistical parametric mapping during recall of abstract designs in a less practiced memory state as well as in a well-practiced (well-encoded) memory state. The results showed an increased activity of the MTL bilaterally (including parahippocampal gyrus extending into hippocampus proper, as well as anterior... (More)

Understanding the role of the medial temporal lobe (MTL) in learning and memory is an important problem in cognitive neuroscience. Memory and learning processes that depend on the function of the MTL and related diencephalic structures (e.g., the anterior and mediodorsal thalamic nuclei) are defined as declarative. We have studied the MTL activity as indicated by regional cerebral blood flow with positron emission tomography and statistical parametric mapping during recall of abstract designs in a less practiced memory state as well as in a well-practiced (well-encoded) memory state. The results showed an increased activity of the MTL bilaterally (including parahippocampal gyrus extending into hippocampus proper, as well as anterior lingual and anterior fusiform gyri) during retrieval in the less practiced memory state compared to the well-practiced memory state, indicating a dynamic role of the MTL in retrieval during the learning processes. The results also showed that the activation of the MTL decreases as the subjects learn to draw abstract designs from memory, indicating a changing role of the MTL during recall in the earlier stages of acquisition compared to the well-encoded declarative memory state.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Hippocampus, Humans, Image Processing, Computer-Assisted, Male, Memory, Mental Recall, Neocortex, Stereotaxic Techniques, Temporal Lobe, Tomography, Emission-Computed, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
in
NeuroImage
volume
6
issue
1
pages
11 pages
publisher
Elsevier
external identifiers
  • Scopus:0031194330
ISSN
1053-8119
DOI
10.1006/nimg.1997.0276
language
English
LU publication?
yes
id
ba20e2cd-4969-46d7-8e45-e4a0952cb7b7
date added to LUP
2016-10-29 15:42:15
date last changed
2016-11-10 13:02:22
@misc{ba20e2cd-4969-46d7-8e45-e4a0952cb7b7,
  abstract     = {<p>Understanding the role of the medial temporal lobe (MTL) in learning and memory is an important problem in cognitive neuroscience. Memory and learning processes that depend on the function of the MTL and related diencephalic structures (e.g., the anterior and mediodorsal thalamic nuclei) are defined as declarative. We have studied the MTL activity as indicated by regional cerebral blood flow with positron emission tomography and statistical parametric mapping during recall of abstract designs in a less practiced memory state as well as in a well-practiced (well-encoded) memory state. The results showed an increased activity of the MTL bilaterally (including parahippocampal gyrus extending into hippocampus proper, as well as anterior lingual and anterior fusiform gyri) during retrieval in the less practiced memory state compared to the well-practiced memory state, indicating a dynamic role of the MTL in retrieval during the learning processes. The results also showed that the activation of the MTL decreases as the subjects learn to draw abstract designs from memory, indicating a changing role of the MTL during recall in the earlier stages of acquisition compared to the well-encoded declarative memory state.</p>},
  author       = {Petersson, K M and Elfgren, C and Ingvar, M},
  issn         = {1053-8119},
  keyword      = {Adult,Hippocampus,Humans,Image Processing, Computer-Assisted,Male,Memory,Mental Recall,Neocortex,Stereotaxic Techniques,Temporal Lobe,Tomography, Emission-Computed,Clinical Trial,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {1},
  pages        = {1--11},
  publisher    = {ARRAY(0xd65a5e8)},
  series       = {NeuroImage},
  title        = {A dynamic role of the medial temporal lobe during retrieval of declarative memory in man},
  url          = {http://dx.doi.org/10.1006/nimg.1997.0276},
  volume       = {6},
  year         = {1997},
}