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Papel del poro de permeabilidad transitoria mitocondrial en los procesos neurodegenerativos

Tornero, D LU ; Ceña, Valentín; González- García, C and Jordán, J (2002) In Revista de Neurologia 35(4). p.61-354
Abstract

AIMS: To review the role played by the mitochondrial permeability transition pore (MPTP) in different physiological and pathological processes.

METHOD: Both genetic and functional alterations in mitochondria can lead to errors that trigger programmed cell death, which in turn give rise to a number of diseases that affect the nervous system. Over the last few years the mitochondrion has been seen as the link between the different signalling pathways involved in some degenerative processes. The mitochondrion seems to play an important part in the cellular decision making that leads, irreversibly, toward the execution phase in cellular death processes. This being the case, the action would be mediated by the permeability of its... (More)

AIMS: To review the role played by the mitochondrial permeability transition pore (MPTP) in different physiological and pathological processes.

METHOD: Both genetic and functional alterations in mitochondria can lead to errors that trigger programmed cell death, which in turn give rise to a number of diseases that affect the nervous system. Over the last few years the mitochondrion has been seen as the link between the different signalling pathways involved in some degenerative processes. The mitochondrion seems to play an important part in the cellular decision making that leads, irreversibly, toward the execution phase in cellular death processes. This being the case, the action would be mediated by the permeability of its membranes, through the formation of the mitochondrial permeability transition pore, and would involve phenomena such as the dissipation of the mitochondrial electrochemical potential and the release of substances from within it. These substances include apoptosis inducing factor (AIF), apoptosis protease activating factor 1 (apaf 1), cytochrome c and members of the protease family: the caspases. These alterations have been described in neurodegenerative pathologies such as Alzheimer s and Parkinson s disease, amyotrophic lateral sclerosis and transmissible spongiform encephalopaties.

CONCLUSIONS: Designing pharmaceutical products capable of interfering with the functions of MPTP would allow a better therapeutic approach in neurological pathologies.

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Please use this url to cite or link to this publication:
author
alternative title
The role of the mitochondrial permeability transition pore in neurodegenerative processes
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Apoptosis, Cell Death, Humans, Ion Channels, Mitochondria, Mitochondrial Membrane Transport Proteins, Neurodegenerative Diseases, Second Messenger Systems, Signal Transduction
in
Revista de Neurologia
volume
35
issue
4
pages
8 pages
publisher
Revista de Neurologia
external identifiers
  • Scopus:0037119563
ISSN
0210-0010
language
Spanish
LU publication?
no
id
bd9f9964-2d7d-474c-859a-885c723030e2
date added to LUP
2016-04-11 15:22:35
date last changed
2016-10-13 05:05:55
@misc{bd9f9964-2d7d-474c-859a-885c723030e2,
  abstract     = {<p>AIMS: To review the role played by the mitochondrial permeability transition pore (MPTP) in different physiological and pathological processes.</p><p>METHOD: Both genetic and functional alterations in mitochondria can lead to errors that trigger programmed cell death, which in turn give rise to a number of diseases that affect the nervous system. Over the last few years the mitochondrion has been seen as the link between the different signalling pathways involved in some degenerative processes. The mitochondrion seems to play an important part in the cellular decision making that leads, irreversibly, toward the execution phase in cellular death processes. This being the case, the action would be mediated by the permeability of its membranes, through the formation of the mitochondrial permeability transition pore, and would involve phenomena such as the dissipation of the mitochondrial electrochemical potential and the release of substances from within it. These substances include apoptosis inducing factor (AIF), apoptosis protease activating factor 1 (apaf 1), cytochrome c and members of the protease family: the caspases. These alterations have been described in neurodegenerative pathologies such as Alzheimer s and Parkinson s disease, amyotrophic lateral sclerosis and transmissible spongiform encephalopaties.</p><p>CONCLUSIONS: Designing pharmaceutical products capable of interfering with the functions of MPTP would allow a better therapeutic approach in neurological pathologies.</p>},
  author       = {Tornero, D and Ceña, Valentín and González- García, C and Jordán, J},
  issn         = {0210-0010},
  keyword      = {Animals,Apoptosis,Cell Death,Humans,Ion Channels,Mitochondria,Mitochondrial Membrane Transport Proteins,Neurodegenerative Diseases,Second Messenger Systems,Signal Transduction},
  language     = {spa},
  month        = {09},
  number       = {4},
  pages        = {61--354},
  publisher    = {ARRAY(0x8e82430)},
  series       = {Revista de Neurologia},
  title        = {Papel del poro de permeabilidad transitoria mitocondrial en los procesos neurodegenerativos},
  volume       = {35},
  year         = {2002},
}