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Catechol-o-methyltransferase, polypeptide sequences and dna molecule coding therefor

(1991) WO1991011513 A3
Abstract
A novel isolation procedure was developed that allowed the purification of rat liver and human placenta catechol-O-methyltransferase (EC 2.1.1.6, COMT) enzyme from rat and human sources to a degree sufficient to allow the amino acid sequencing of the enzyme. Recombinant clones directed against the rat liver and human placenta COMT are identified and sequenced. The isolation of pure and recombinant COMT and antibodies thereto, according to the invention, is useful as a medical and pharmacological tool for the development of COMT inhibitors and as a clinical tool for the assay of COMT expression in various disease states.
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organization
publishing date
type
Patent
publication status
published
subject
keywords
catechol-O-methyltransferase (COMT), Sequence Homology Amino Acid, enzmes
patent number
WO1991011513 A3
language
English
LU publication?
yes
id
d359f84f-dce1-45b6-b22f-f3eac7b75b3d
date added to LUP
2016-04-20 13:59:21
date last changed
2016-04-20 13:59:21
@misc{d359f84f-dce1-45b6-b22f-f3eac7b75b3d,
  abstract     = {A novel isolation procedure was developed that allowed the purification of rat liver and human placenta catechol-O-methyltransferase (EC 2.1.1.6, COMT) enzyme from rat and human sources to a degree sufficient to allow the amino acid sequencing of the enzyme. Recombinant clones directed against the rat liver and human placenta COMT are identified and sequenced. The isolation of pure and recombinant COMT and antibodies thereto, according to the invention, is useful as a medical and pharmacological tool for the development of COMT inhibitors and as a clinical tool for the assay of COMT expression in various disease states.},
  keyword      = {catechol-O-methyltransferase (COMT),Sequence Homology Amino Acid,enzmes},
  language     = {eng},
  month        = {10},
  title        = {Catechol-o-methyltransferase, polypeptide sequences and dna molecule coding therefor},
  year         = {1991},
}