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Platelet-associated IgG in childhood idiopathic thrombocytopenic purpura : measurements on intact and solubilized platelets and after gammaglobulin treatment

Ljung, R. LU ; Nilsson, Inga Marie; Frohm, B. and Holmberg, Lars LU (1986) In Scandinavian Journal of Haematology 36(4). p.402-407
Abstract

An immunoradiometric assay was developed for determining platelet-associated IgG (PAIgG) both on intact and solubilized platelets. In 20 healthy subjects PAIgG was 0.28 ± 0.20 ng/106 platelets and 2.2 ± 1.1 ng/106 platelets on intact and on solubilized platelets, respectively. 13 children with acute ITP all had increased concentrations of PAIgG, but no correlation was found between the severity of thrombocytopenia and PAIgG concentrations, either on intact or on solubilized platelets. Neither was there any correlation of the increase in PAIgG between intact and solubilized preparations. 3 out of 4 children who received high-dose i.v. gammaglobulin showed a concomitant normalization of the platelet count and of the... (More)

An immunoradiometric assay was developed for determining platelet-associated IgG (PAIgG) both on intact and solubilized platelets. In 20 healthy subjects PAIgG was 0.28 ± 0.20 ng/106 platelets and 2.2 ± 1.1 ng/106 platelets on intact and on solubilized platelets, respectively. 13 children with acute ITP all had increased concentrations of PAIgG, but no correlation was found between the severity of thrombocytopenia and PAIgG concentrations, either on intact or on solubilized platelets. Neither was there any correlation of the increase in PAIgG between intact and solubilized preparations. 3 out of 4 children who received high-dose i.v. gammaglobulin showed a concomitant normalization of the platelet count and of the PAIgG concentration both on intact and lyzed platelets. The remaining child did not respond to gammaglobulin and continued to have abnormal PAIgG.

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author
organization
publishing date
type
Contribution to journal
publication status
published
in
Scandinavian Journal of Haematology
volume
36
issue
4
pages
402 - 407
external identifiers
  • Scopus:0022469655
ISSN
0036-553X
DOI
10.1111/j.1600-0609.1986.tb01757.x
language
English
LU publication?
yes
id
d54818e8-e9a1-466c-a424-49e714405f6c
date added to LUP
2016-10-26 13:58:43
date last changed
2016-11-15 10:17:47
@misc{d54818e8-e9a1-466c-a424-49e714405f6c,
  abstract     = {<p>An immunoradiometric assay was developed for determining platelet-associated IgG (PAIgG) both on intact and solubilized platelets. In 20 healthy subjects PAIgG was 0.28 ± 0.20 ng/10<sup>6</sup> platelets and 2.2 ± 1.1 ng/10<sup>6</sup> platelets on intact and on solubilized platelets, respectively. 13 children with acute ITP all had increased concentrations of PAIgG, but no correlation was found between the severity of thrombocytopenia and PAIgG concentrations, either on intact or on solubilized platelets. Neither was there any correlation of the increase in PAIgG between intact and solubilized preparations. 3 out of 4 children who received high-dose i.v. gammaglobulin showed a concomitant normalization of the platelet count and of the PAIgG concentration both on intact and lyzed platelets. The remaining child did not respond to gammaglobulin and continued to have abnormal PAIgG.</p>},
  author       = {Ljung, R. and Nilsson, Inga Marie and Frohm, B. and Holmberg, Lars},
  issn         = {0036-553X},
  language     = {eng},
  number       = {4},
  pages        = {402--407},
  series       = {Scandinavian Journal of Haematology},
  title        = {Platelet-associated IgG in childhood idiopathic thrombocytopenic purpura : measurements on intact and solubilized platelets and after gammaglobulin treatment},
  url          = {http://dx.doi.org/10.1111/j.1600-0609.1986.tb01757.x},
  volume       = {36},
  year         = {1986},
}