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The effect of erythropoietin treatment on arteriovenous haemodialysis fistula/graft : A prospective study with colour flow doppler ultrasonography

Fischer-Colbrie, Werner; Clyne, Naomi LU ; Jogestrand, Tomas and Takolander, Rabbe (1994) In European Journal of Vascular Surgery 8(3). p.346-350
Abstract

To determine the effect of erythropoietin (EPO) on patency the haemodynamics and morphology in haemodialysis fistula/graft were prospectively assessed using ultrasonographic two-dimensional imaging and colour flow Doppler together with pulsed Doppler, prior to and during partial correction of anaemia with EPO. Nineteen radiocephalic fistula and 11 loop grafts in 30 patients on routine maintenance haemodialysis were investigated prior to EPO treatment. A significant stenosis defined as a localised 100% increase in flow velocity was found in the arterial inflow in seven (23%) patients, in the loop graft in seven (64% of loop grafts) patients, and in the venous segments in 23 (77%) patients. Fourteen patients were rescanned after more than... (More)

To determine the effect of erythropoietin (EPO) on patency the haemodynamics and morphology in haemodialysis fistula/graft were prospectively assessed using ultrasonographic two-dimensional imaging and colour flow Doppler together with pulsed Doppler, prior to and during partial correction of anaemia with EPO. Nineteen radiocephalic fistula and 11 loop grafts in 30 patients on routine maintenance haemodialysis were investigated prior to EPO treatment. A significant stenosis defined as a localised 100% increase in flow velocity was found in the arterial inflow in seven (23%) patients, in the loop graft in seven (64% of loop grafts) patients, and in the venous segments in 23 (77%) patients. Fourteen patients were rescanned after more than 200 days of EPO therapy. There was a significant increase in haemoglobin (84 ± 14g/l to 104 ± 18g/l) and haematocrit (24 ± 4 to 31 ± 5%) during this time. One arterial, four loop grafts and two venous stenoses appeared or increased in severity, and one venous return flow segment had occluded. Blood flow according to ultrasonography was unchanged. Of the 16 patients lost to follow-up, three underwent surgical intervention (clinical failure rate 0.20 access/year). EPO therapy may contribute to minor changes in access haemodynamics but does not seem to be detrimental to patency. © 1994 W. B. Saunders Company Ltd.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Colour Doppler ultrasonography, Erythropoietin, Haemodialysis arteriovenous fistula/graft
in
European Journal of Vascular Surgery
volume
8
issue
3
pages
5 pages
publisher
Elsevier
external identifiers
  • Scopus:0028345988
ISSN
0950-821X
DOI
10.1016/S0950-821X(05)80154-9
language
English
LU publication?
no
id
d9dea394-eff4-41d9-afc1-db7320b2e705
date added to LUP
2016-08-30 22:03:07
date last changed
2016-09-16 15:09:50
@misc{d9dea394-eff4-41d9-afc1-db7320b2e705,
  abstract     = {<p>To determine the effect of erythropoietin (EPO) on patency the haemodynamics and morphology in haemodialysis fistula/graft were prospectively assessed using ultrasonographic two-dimensional imaging and colour flow Doppler together with pulsed Doppler, prior to and during partial correction of anaemia with EPO. Nineteen radiocephalic fistula and 11 loop grafts in 30 patients on routine maintenance haemodialysis were investigated prior to EPO treatment. A significant stenosis defined as a localised 100% increase in flow velocity was found in the arterial inflow in seven (23%) patients, in the loop graft in seven (64% of loop grafts) patients, and in the venous segments in 23 (77%) patients. Fourteen patients were rescanned after more than 200 days of EPO therapy. There was a significant increase in haemoglobin (84 ± 14g/l to 104 ± 18g/l) and haematocrit (24 ± 4 to 31 ± 5%) during this time. One arterial, four loop grafts and two venous stenoses appeared or increased in severity, and one venous return flow segment had occluded. Blood flow according to ultrasonography was unchanged. Of the 16 patients lost to follow-up, three underwent surgical intervention (clinical failure rate 0.20 access/year). EPO therapy may contribute to minor changes in access haemodynamics but does not seem to be detrimental to patency. © 1994 W. B. Saunders Company Ltd.</p>},
  author       = {Fischer-Colbrie, Werner and Clyne, Naomi and Jogestrand, Tomas and Takolander, Rabbe},
  issn         = {0950-821X},
  keyword      = {Colour Doppler ultrasonography,Erythropoietin,Haemodialysis arteriovenous fistula/graft},
  language     = {eng},
  number       = {3},
  pages        = {346--350},
  publisher    = {ARRAY(0x7fdef10)},
  series       = {European Journal of Vascular Surgery},
  title        = {The effect of erythropoietin treatment on arteriovenous haemodialysis fistula/graft : A prospective study with colour flow doppler ultrasonography},
  url          = {http://dx.doi.org/10.1016/S0950-821X(05)80154-9},
  volume       = {8},
  year         = {1994},
}