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Differential release of molecular markers in joint disease

Saxne, Tore LU (1995) In Acta Orthopedica 66 (suppl 266). p.80-83
Abstract
Cartilage and bone, the principal tissues of the diar-throdial joint, are dynamic tissues with continuous matrix turnover. These tissues, like all connective tissues, contain few cells surrounded by an abundant matrix. The cells, e.g. the chondrocytes in cartilage, regulate both synthesis and degradation of the matrix constituents in response to various environmental factors, such as hormones, nutrients, mechanical load or cytokines. Under normal conditions, the balance between matrix catabolism and anabolism is well regulated, and the tissue integrity is maintained. However, in pathological conditions, such as rheumatoid arthritis (RA), arthrosis (OA) or traumatic conditions, changes in the tissue turnover occur which disturb the balance.... (More)
Cartilage and bone, the principal tissues of the diar-throdial joint, are dynamic tissues with continuous matrix turnover. These tissues, like all connective tissues, contain few cells surrounded by an abundant matrix. The cells, e.g. the chondrocytes in cartilage, regulate both synthesis and degradation of the matrix constituents in response to various environmental factors, such as hormones, nutrients, mechanical load or cytokines. Under normal conditions, the balance between matrix catabolism and anabolism is well regulated, and the tissue integrity is maintained. However, in pathological conditions, such as rheumatoid arthritis (RA), arthrosis (OA) or traumatic conditions, changes in the tissue turnover occur which disturb the balance. Thus in RA the inflammatory process induces cytokine-mediated matrix degradation of cartilage with concomitant depression of synthesis gradually leading to loss of the entire matrix (Harris 1990, Heinegård and Saxne 1991). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
joint disease, molecular marker
in
Acta Orthopedica
volume
66 (suppl 266)
pages
80 - 83
publisher
Taylor & Francis
external identifiers
  • Scopus:0029616037
language
English
LU publication?
yes
id
dc681ae6-81f7-4a96-bc2d-dd25a6a1a882
date added to LUP
2016-05-07 10:26:15
date last changed
2016-10-13 05:08:17
@misc{dc681ae6-81f7-4a96-bc2d-dd25a6a1a882,
  abstract     = {Cartilage and bone, the principal tissues of the diar-throdial joint, are dynamic tissues with continuous matrix turnover. These tissues, like all connective tissues, contain few cells surrounded by an abundant matrix. The cells, e.g. the chondrocytes in cartilage, regulate both synthesis and degradation of the matrix constituents in response to various environmental factors, such as hormones, nutrients, mechanical load or cytokines. Under normal conditions, the balance between matrix catabolism and anabolism is well regulated, and the tissue integrity is maintained. However, in pathological conditions, such as rheumatoid arthritis (RA), arthrosis (OA) or traumatic conditions, changes in the tissue turnover occur which disturb the balance. Thus in RA the inflammatory process induces cytokine-mediated matrix degradation of cartilage with concomitant depression of synthesis gradually leading to loss of the entire matrix (Harris 1990, Heinegård and Saxne 1991).},
  author       = {Saxne, Tore},
  keyword      = {joint disease,molecular marker},
  language     = {eng},
  pages        = {80--83},
  publisher    = {ARRAY(0x87ffa68)},
  series       = {Acta Orthopedica},
  title        = {Differential release of molecular markers in joint disease},
  volume       = {66 (suppl 266)},
  year         = {1995},
}