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Therapeutic effects on cartilage metabolism in arthritis as measured by release of proteoglycan structures into the synovial fluid.

Saxne, Tore LU ; Heinegård, Dick LU and Wollheim, Frank LU (1986) In Annals of the Rheumatic Diseases 45(6). p.491-497
Abstract
Proteoglycans are molecules that are degraded and released from the articular cartilage into the synovial fluid early in an arthritic process. Such released proteoglycans were quantified by an enzyme linked immunosorbent assay (ELISA). The proteoglycan content in synovial fluid from patients with various knee joint arthritides was constant in two samples withdrawn five days apart. To determine if therapeutic measures were paralleled by effects directly on the articular cartilage the patients were treated with local injections of glucocorticoids. In all patients the glucocorticoids induced a reduction of the proteoglycan content in the synovial fluid, reflecting their effects on the cartilage. In two patients with spontaneous remission of... (More)
Proteoglycans are molecules that are degraded and released from the articular cartilage into the synovial fluid early in an arthritic process. Such released proteoglycans were quantified by an enzyme linked immunosorbent assay (ELISA). The proteoglycan content in synovial fluid from patients with various knee joint arthritides was constant in two samples withdrawn five days apart. To determine if therapeutic measures were paralleled by effects directly on the articular cartilage the patients were treated with local injections of glucocorticoids. In all patients the glucocorticoids induced a reduction of the proteoglycan content in the synovial fluid, reflecting their effects on the cartilage. In two patients with spontaneous remission of their arthritis a reduction in the proteoglycan content in the synovial fluid was also noted. The quantification of proteoglycans in synovial fluid appears to have potential as a useful tool for monitoring the effects of therapy on cartilage metabolism. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arthritis, proteoglycan, synovial fluid
in
Annals of the Rheumatic Diseases
volume
45
issue
6
pages
491 - 497
publisher
British Medical Association
external identifiers
  • Scopus:0022547287
ISSN
1468-2060
language
English
LU publication?
yes
id
de11a351-dbc9-4620-83cb-5cba483ce8c2
date added to LUP
2016-05-06 15:48:27
date last changed
2016-11-27 04:40:13
@misc{de11a351-dbc9-4620-83cb-5cba483ce8c2,
  abstract     = {Proteoglycans are molecules that are degraded and released from the articular cartilage into the synovial fluid early in an arthritic process. Such released proteoglycans were quantified by an enzyme linked immunosorbent assay (ELISA). The proteoglycan content in synovial fluid from patients with various knee joint arthritides was constant in two samples withdrawn five days apart. To determine if therapeutic measures were paralleled by effects directly on the articular cartilage the patients were treated with local injections of glucocorticoids. In all patients the glucocorticoids induced a reduction of the proteoglycan content in the synovial fluid, reflecting their effects on the cartilage. In two patients with spontaneous remission of their arthritis a reduction in the proteoglycan content in the synovial fluid was also noted. The quantification of proteoglycans in synovial fluid appears to have potential as a useful tool for monitoring the effects of therapy on cartilage metabolism.},
  author       = {Saxne, Tore and Heinegård, Dick and Wollheim, Frank},
  issn         = {1468-2060},
  keyword      = {arthritis,proteoglycan,synovial fluid},
  language     = {eng},
  number       = {6},
  pages        = {491--497},
  publisher    = {ARRAY(0x81fb420)},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Therapeutic effects on cartilage metabolism in arthritis as measured by release of proteoglycan structures into the synovial fluid.},
  volume       = {45},
  year         = {1986},
}