Advanced

Perturbations in blood Ca2+ do not affect the activity of rat stomach enterochromaffin-like cells.

Håkanson, Rolf LU ; Gagnemo Persson, Rebecca LU and Surve, Vikas LU (1995) In Scandinavian Journal of Gastroenterology 31(3). p.217-221
Abstract
BACKGROUND:
Gastrin stimulates uptake of Ca(2)+ into bone and causes transient hypocalcemia, possibly by releasing a peptide hormone from enterochromaffin-like (ECL) cells, which are histamine- and peptidehormone-producing cells in the acid-producing part of the stomach. However, if ECL cells secrete a calciotropic hormone, it is to be expected that their activity is affected by the serum Ca(2)+ concentration.
METHODS:
Food-deprived male rats were infused with human (Leu)15-gastrin-17 and/or ethylenediamine-tetraacetic acid and CaCl(2). The blood Ca(2)+ level was monitored throughout the experiments (3 h), and the serum concentrations of gastrin, parathyroid hormone, and calcitonin were measured at death. The activity of the... (More)
BACKGROUND:
Gastrin stimulates uptake of Ca(2)+ into bone and causes transient hypocalcemia, possibly by releasing a peptide hormone from enterochromaffin-like (ECL) cells, which are histamine- and peptidehormone-producing cells in the acid-producing part of the stomach. However, if ECL cells secrete a calciotropic hormone, it is to be expected that their activity is affected by the serum Ca(2)+ concentration.
METHODS:
Food-deprived male rats were infused with human (Leu)15-gastrin-17 and/or ethylenediamine-tetraacetic acid and CaCl(2). The blood Ca(2)+ level was monitored throughout the experiments (3 h), and the serum concentrations of gastrin, parathyroid hormone, and calcitonin were measured at death. The activity of the ECL cells was assessed by measuring the histidine decarboxylase (HDC) activity.
RESULTS:
Gastrin produced the expected increase in HDC activity, but neither hyper- nor hypo-calcemia affected the RDC activity of either hypo- or hyper-gastrinemic rats.
CONCLUSION:
Perturbations in blood Ca(2)+ do not seem to affect ECL cells, which is at odds with the view that ECL cells harbor a calciotropic hormone.
(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Gastroenterology
volume
31
issue
3
pages
5 pages
publisher
Taylor & Francis
ISSN
1502-7708
language
English
LU publication?
yes
id
e1952a30-c017-444b-817f-7ca43021d6bb
date added to LUP
2016-08-19 14:01:47
date last changed
2016-09-16 09:04:44
@misc{e1952a30-c017-444b-817f-7ca43021d6bb,
  abstract     = {BACKGROUND: <br/>Gastrin stimulates uptake of Ca(2)+ into bone and causes transient hypocalcemia, possibly by releasing a peptide hormone from enterochromaffin-like (ECL) cells, which are histamine- and peptidehormone-producing cells in the acid-producing part of the stomach. However, if ECL cells secrete a calciotropic hormone, it is to be expected that their activity is affected by the serum Ca(2)+ concentration.<br/>METHODS: <br/>Food-deprived male rats were infused with human (Leu)15-gastrin-17 and/or ethylenediamine-tetraacetic acid and CaCl(2). The blood Ca(2)+ level was monitored throughout the experiments (3 h), and the serum concentrations of gastrin, parathyroid hormone, and calcitonin were measured at death. The activity of the ECL cells was assessed by measuring the histidine decarboxylase (HDC) activity.<br/>RESULTS: <br/>Gastrin produced the expected increase in HDC activity, but neither hyper- nor hypo-calcemia affected the RDC activity of either hypo- or hyper-gastrinemic rats.<br/>CONCLUSION: <br/>Perturbations in blood Ca(2)+ do not seem to affect ECL cells, which is at odds with the view that ECL cells harbor a calciotropic hormone.<br/>},
  author       = {Håkanson, Rolf and Gagnemo Persson, Rebecca and Surve, Vikas},
  issn         = {1502-7708},
  language     = {eng},
  number       = {3},
  pages        = {217--221},
  publisher    = {ARRAY(0x8929e98)},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Perturbations in blood Ca2+ do not affect the activity of rat stomach enterochromaffin-like cells.},
  volume       = {31},
  year         = {1995},
}