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Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina

Perez, M T LU and Caminos, E (1995) In Neuroscience Letters 183(1-2). p.9-96
Abstract

The expression of mRNA coding for brain-derived neurotrophic factor (BDNF) and for its functional receptor, the full-length tyrosine kinase receptor trkB (trkB mRNA), was examined in early postnatal and adult rat retina by in situ hybridization using digoxygenin and radioactively-labeled oligonucleotide probes. BDNF and trkB mRNAs are expressed in the ganglion cell layer at postnatal-days (PN) 1, 4, 7, 14, 60, in proximal neuroblastic layer (PN 1, 4, 7), and proximal inner nuclear layer (PN 14, 60). Subpopulations of developing and mature retinal cells are thus capable of synthesizing BDNF.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Autoradiography, Brain-Derived Neurotrophic Factor, Gene Expression, Humans, In Situ Hybridization, Infant, Newborn, Nerve Tissue Proteins, RNA, Messenger, Rats, Rats, Sprague-Dawley, Receptors, Nerve Growth Factor, Retina, Journal Article, Research Support, Non-U.S. Gov't
in
Neuroscience Letters
volume
183
issue
1-2
pages
9 - 96
publisher
Elsevier
external identifiers
  • Scopus:0028855060
ISSN
0304-3940
DOI
10.1016/0304-3940(94)11123-Z
language
English
LU publication?
yes
id
e9ad4675-f1ff-47e4-bb4b-1b473617ddfe
date added to LUP
2016-10-27 19:33:42
date last changed
2016-11-28 12:06:32
@misc{e9ad4675-f1ff-47e4-bb4b-1b473617ddfe,
  abstract     = {<p>The expression of mRNA coding for brain-derived neurotrophic factor (BDNF) and for its functional receptor, the full-length tyrosine kinase receptor trkB (trkB mRNA), was examined in early postnatal and adult rat retina by in situ hybridization using digoxygenin and radioactively-labeled oligonucleotide probes. BDNF and trkB mRNAs are expressed in the ganglion cell layer at postnatal-days (PN) 1, 4, 7, 14, 60, in proximal neuroblastic layer (PN 1, 4, 7), and proximal inner nuclear layer (PN 14, 60). Subpopulations of developing and mature retinal cells are thus capable of synthesizing BDNF.</p>},
  author       = {Perez, M T and Caminos, E},
  issn         = {0304-3940},
  keyword      = {Animals,Autoradiography,Brain-Derived Neurotrophic Factor,Gene Expression,Humans,In Situ Hybridization,Infant, Newborn,Nerve Tissue Proteins,RNA, Messenger,Rats,Rats, Sprague-Dawley,Receptors, Nerve Growth Factor,Retina,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {01},
  number       = {1-2},
  pages        = {9--96},
  publisher    = {ARRAY(0xbac2388)},
  series       = {Neuroscience Letters},
  title        = {Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina},
  url          = {http://dx.doi.org/10.1016/0304-3940(94)11123-Z},
  volume       = {183},
  year         = {1995},
}