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Aspects on the interaction of Streptococcus pneumoniae and Haemophilus influenzae with human respiratory tract mucosa

Håkansson, Anders P LU ; Carlstedt, I LU ; Davies, J LU ; Mossberg, A K LU ; Sabharwal, H and Svanborg, C LU (1996) In American Journal of Respiratory and Critical Care Medicine 154(4 Pt 2). p.91-187
Abstract

Haemophilus influenzae and Streptococcus pneumoniae are common causes of respiratory tract infections. H. influenzae attach to receptor epitopes in mucins and in epithelial cell membranes. Attachment is followed by an epithelial cell cytokine response. Secreted cytokines then initiate inflammation, upset the integrity of the mucosal barrier, and lead to disease. S. pneumoniae do not bind to mucins but attach to respiratory tract epithelial cells. Attachment is increased by viral infection of the epithelial cells. Unlike H. Influenzae, S. pneumoniae induce apoptosis in epithelial cells, thus disrupting the mucosal barrier. Attachment and persistence is counterbalanced by antiadhesive as well as bactericidal molecules in secretions such... (More)

Haemophilus influenzae and Streptococcus pneumoniae are common causes of respiratory tract infections. H. influenzae attach to receptor epitopes in mucins and in epithelial cell membranes. Attachment is followed by an epithelial cell cytokine response. Secreted cytokines then initiate inflammation, upset the integrity of the mucosal barrier, and lead to disease. S. pneumoniae do not bind to mucins but attach to respiratory tract epithelial cells. Attachment is increased by viral infection of the epithelial cells. Unlike H. Influenzae, S. pneumoniae induce apoptosis in epithelial cells, thus disrupting the mucosal barrier. Attachment and persistence is counterbalanced by antiadhesive as well as bactericidal molecules in secretions such as human milk. These examples illustrate the balance between host defenses and microbial virulence as it has coevolved to maintain the health of the respiratory mucosa.

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organization
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Contribution to journal
publication status
published
subject
keywords
Adenovirus Infections, Human, Bacterial Adhesion, Cells, Cultured, Cytokines, Haemophilus influenzae, Humans, Mucous Membrane, Respiratory System, Respiratory Tract Infections, Streptococcus pneumoniae
in
American Journal of Respiratory and Critical Care Medicine
volume
154
issue
4 Pt 2
pages
91 - 187
publisher
Am Thoracic Soc
external identifiers
  • Scopus:0029910880
ISSN
1073-449X
DOI
10.1164/ajrccm/154.4_Pt_2.S187
language
English
LU publication?
yes
id
e9ce7b6e-3874-46fe-8a4b-722898318a7c
date added to LUP
2016-05-21 11:31:37
date last changed
2016-10-13 05:09:15
@misc{e9ce7b6e-3874-46fe-8a4b-722898318a7c,
  abstract     = {<p>Haemophilus influenzae and Streptococcus pneumoniae are common causes of respiratory tract infections. H. influenzae attach to receptor epitopes in mucins and in epithelial cell membranes. Attachment is followed by an epithelial cell cytokine response. Secreted cytokines then initiate inflammation, upset the integrity of the mucosal barrier, and lead to disease. S. pneumoniae do not bind to mucins but attach to respiratory tract epithelial cells. Attachment is increased by viral infection of the epithelial cells. Unlike H. Influenzae, S. pneumoniae induce apoptosis in epithelial cells, thus disrupting the mucosal barrier. Attachment and persistence is counterbalanced by antiadhesive as well as bactericidal molecules in secretions such as human milk. These examples illustrate the balance between host defenses and microbial virulence as it has coevolved to maintain the health of the respiratory mucosa.</p>},
  author       = {Håkansson, Anders P and Carlstedt, I and Davies, J and Mossberg, A K and Sabharwal, H and Svanborg, C},
  issn         = {1073-449X},
  keyword      = {Adenovirus Infections, Human,Bacterial Adhesion,Cells, Cultured,Cytokines,Haemophilus influenzae,Humans,Mucous Membrane,Respiratory System,Respiratory Tract Infections,Streptococcus pneumoniae},
  language     = {eng},
  number       = {4 Pt 2},
  pages        = {91--187},
  publisher    = {ARRAY(0x8c094f8)},
  series       = {American Journal of Respiratory and Critical Care Medicine},
  title        = {Aspects on the interaction of Streptococcus pneumoniae and Haemophilus influenzae with human respiratory tract mucosa},
  url          = {http://dx.doi.org/10.1164/ajrccm/154.4_Pt_2.S187},
  volume       = {154},
  year         = {1996},
}