Advanced

Cartilage derived proteoglycans in body fluids of children. Inverse correlation with age.

Saxne, Tore LU ; Castro, Fresia; Rydholm, Urban LU and Svantesson, Helena (1989) In Journal of Rheumatology 16(10). p.1341-1344
Abstract
We have previously shown synovial fluid (SF) proteoglycan concentrations to be sensitive markers of altered cartilage metabolism in arthritis. We determined the proteoglycan concentrations in sera and SF from 23 patients with juvenile chronic arthritis and in sera from 30 healthy children by a specific enzyme linked immunosorbent assay. In both groups of children, decreasing concentrations of proteoglycans were seen during growth. Changes were most marked at the age of 12-13. The serum levels were higher in the healthy children. Our results suggest an age related metabolic change of articular cartilage, resulting in diminished release of proteoglycans to SF and blood with growing age up to 20 years. Measurement of proteoglycans could be a... (More)
We have previously shown synovial fluid (SF) proteoglycan concentrations to be sensitive markers of altered cartilage metabolism in arthritis. We determined the proteoglycan concentrations in sera and SF from 23 patients with juvenile chronic arthritis and in sera from 30 healthy children by a specific enzyme linked immunosorbent assay. In both groups of children, decreasing concentrations of proteoglycans were seen during growth. Changes were most marked at the age of 12-13. The serum levels were higher in the healthy children. Our results suggest an age related metabolic change of articular cartilage, resulting in diminished release of proteoglycans to SF and blood with growing age up to 20 years. Measurement of proteoglycans could be a useful tool for studying this process. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arthritis/blood, Arthrography, Child, Preschool, Chronic Disease, Proteoglycans/blood
in
Journal of Rheumatology
volume
16
issue
10
pages
1341 - 1344
publisher
J Rheumatol Publ Co
external identifiers
  • Scopus:0024456918
ISSN
0315-162X
language
English
LU publication?
yes
id
f673eba3-45b8-4969-a535-ef602508c994
date added to LUP
2016-05-06 16:22:16
date last changed
2016-05-26 12:54:24
@misc{f673eba3-45b8-4969-a535-ef602508c994,
  abstract     = {We have previously shown synovial fluid (SF) proteoglycan concentrations to be sensitive markers of altered cartilage metabolism in arthritis. We determined the proteoglycan concentrations in sera and SF from 23 patients with juvenile chronic arthritis and in sera from 30 healthy children by a specific enzyme linked immunosorbent assay. In both groups of children, decreasing concentrations of proteoglycans were seen during growth. Changes were most marked at the age of 12-13. The serum levels were higher in the healthy children. Our results suggest an age related metabolic change of articular cartilage, resulting in diminished release of proteoglycans to SF and blood with growing age up to 20 years. Measurement of proteoglycans could be a useful tool for studying this process.},
  author       = {Saxne, Tore and Castro, Fresia and Rydholm, Urban and Svantesson, Helena},
  issn         = {0315-162X},
  keyword      = {Arthritis/blood,Arthrography,Child, Preschool,Chronic Disease,Proteoglycans/blood},
  language     = {eng},
  number       = {10},
  pages        = {1341--1344},
  publisher    = {ARRAY(0xa6f8f40)},
  series       = {Journal of Rheumatology},
  title        = {Cartilage derived proteoglycans in body fluids of children. Inverse correlation with age.},
  volume       = {16},
  year         = {1989},
}