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Cartilage proteoglycans in synovial fluid and serum in patients with inflammatory joint disease. Relation to systemic treatment.

Saxne, Tore LU ; Heinegård, Dick LU and Wollheim, Frank LU (1987) In Arthritis & Rheumatism 30(9). p.972-979
Abstract
Proteoglycan concentrations in knee joint synovial fluid and in serum from patients with various inflammatory arthritides were studied using an enzyme-linked immunosorbent assay. Patients with reactive arthritis, calcium pyrophosphate arthorpathy, and juvenile rheumatoid arthritis (age ≤20 years) had the highest synovial fluid concentrations. These values differed significantly (P < 0.001) from those in patients with rheumatoid arthritis, psoriatic arthropathy, and chronic HLA-B27-associated arthropathy. Rheumatoid arthritis patients receiving low-dose prednisolone treatment had higher synovial fluid (P = 0.006) and serum (P < 0.001) proteoglycan concentrations than did those taking nonsteroidal antiinflammatory drugs or slow-acting... (More)
Proteoglycan concentrations in knee joint synovial fluid and in serum from patients with various inflammatory arthritides were studied using an enzyme-linked immunosorbent assay. Patients with reactive arthritis, calcium pyrophosphate arthorpathy, and juvenile rheumatoid arthritis (age ≤20 years) had the highest synovial fluid concentrations. These values differed significantly (P < 0.001) from those in patients with rheumatoid arthritis, psoriatic arthropathy, and chronic HLA-B27-associated arthropathy. Rheumatoid arthritis patients receiving low-dose prednisolone treatment had higher synovial fluid (P = 0.006) and serum (P < 0.001) proteoglycan concentrations than did those taking nonsteroidal antiinflammatory drugs or slow-acting antirheumatic drugs. Serum proteoglycan concentrations were near the detection limits, and did not correlate with levels found in paired samples of knee joint synovial fluid. Patients with calcium pyrophosphate arthropathy had the highest mean serum level of proteoglycan. This assay of proteoglycan antigens is a useful tool in the study of proteoglycan metabolism in patients with joint disease. With its use, differences between disease groups and effects of therapy can be distinguished. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antiinflammatory agent, arthritis, cartilage
in
Arthritis & Rheumatism
volume
30
issue
9
pages
972 - 979
publisher
John Wiley & Sons
external identifiers
  • Scopus:0023615918
language
English
LU publication?
yes
id
f84df4dd-8fe7-4b4f-b412-8e90c806ced7
date added to LUP
2016-05-06 15:51:11
date last changed
2016-09-13 15:28:46
@misc{f84df4dd-8fe7-4b4f-b412-8e90c806ced7,
  abstract     = {Proteoglycan concentrations in knee joint synovial fluid and in serum from patients with various inflammatory arthritides were studied using an enzyme-linked immunosorbent assay. Patients with reactive arthritis, calcium pyrophosphate arthorpathy, and juvenile rheumatoid arthritis (age ≤20 years) had the highest synovial fluid concentrations. These values differed significantly (P &lt; 0.001) from those in patients with rheumatoid arthritis, psoriatic arthropathy, and chronic HLA-B27-associated arthropathy. Rheumatoid arthritis patients receiving low-dose prednisolone treatment had higher synovial fluid (P = 0.006) and serum (P &lt; 0.001) proteoglycan concentrations than did those taking nonsteroidal antiinflammatory drugs or slow-acting antirheumatic drugs. Serum proteoglycan concentrations were near the detection limits, and did not correlate with levels found in paired samples of knee joint synovial fluid. Patients with calcium pyrophosphate arthropathy had the highest mean serum level of proteoglycan. This assay of proteoglycan antigens is a useful tool in the study of proteoglycan metabolism in patients with joint disease. With its use, differences between disease groups and effects of therapy can be distinguished.},
  author       = {Saxne, Tore and Heinegård, Dick and Wollheim, Frank},
  keyword      = {antiinflammatory agent,arthritis,cartilage},
  language     = {eng},
  number       = {9},
  pages        = {972--979},
  publisher    = {ARRAY(0x8dd5b80)},
  series       = {Arthritis & Rheumatism},
  title        = {Cartilage proteoglycans in synovial fluid and serum in patients with inflammatory joint disease. Relation to systemic treatment.},
  volume       = {30},
  year         = {1987},
}