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Ferrous sulphate gels for determination of absorbed dose distributions using MRI technique : basic studies

Olsson, L E LU ; Petersson, J Stefan LU ; Ahlgren, Lars and Mattsson, S LU (1989) In Physics in Medicine and Biology 34(1). p.43-52
Abstract

Two gels have been found to be suitable to load with ferrous sulphate solution. In these soft tissue equivalent phantoms, the absorbed dose distribution can be measured after irradiation in clinically used MR imaging equipment. The present studies were carried out using a 0.25 T NMR analyser without imaging properties. A ferrous sulphate solution, 0.05 M with respect to sulphuric acid, can be gelled with 4% gelatin to give a dosemeter which has a response which is linearly correlated (r = 0.998) with the absorbed dose in the interval 0-40 Gy. Ferrous sulphate solution can also be gelled with 1% agarose, but this gel has to be purged with oxygen to obtain a linear relationship (r = 0.997) in the same absorbed dose interval. The ferrous... (More)

Two gels have been found to be suitable to load with ferrous sulphate solution. In these soft tissue equivalent phantoms, the absorbed dose distribution can be measured after irradiation in clinically used MR imaging equipment. The present studies were carried out using a 0.25 T NMR analyser without imaging properties. A ferrous sulphate solution, 0.05 M with respect to sulphuric acid, can be gelled with 4% gelatin to give a dosemeter which has a response which is linearly correlated (r = 0.998) with the absorbed dose in the interval 0-40 Gy. Ferrous sulphate solution can also be gelled with 1% agarose, but this gel has to be purged with oxygen to obtain a linear relationship (r = 0.997) in the same absorbed dose interval. The ferrous sulphate loaded gels have a sensitivity which is a factor of 2.2 or 4.0 times higher for gelatin and agarose, respectively, than the ordinary dosemeter solution. Because the standard deviation of background measurements is higher for the gels than for the dosemeter solution, the minimum detectable absorbed dose is about the same, or 1.0 Gy, for the two gels and the dosemeter solution. The sensitivity of the ferrous sulphate loaded gels shows no dependence on dose rate if the mean dose rate and the absorbed dose per pulse are within the limits normally used by accelerators for radiotherapy.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ferrous Compounds, Gels, In Vitro Techniques, Magnetic Resonance Imaging, Radiation Dosage
in
Physics in Medicine and Biology
volume
34
issue
1
pages
10 pages
publisher
IOP Publishing
external identifiers
  • Scopus:0024569814
ISSN
0031-9155
DOI
10.1088/0031-9155/34/1/004
language
English
LU publication?
yes
id
fa19bb08-a07d-47de-a59c-8c8f459be079
date added to LUP
2016-08-16 12:19:18
date last changed
2016-08-30 15:10:12
@misc{fa19bb08-a07d-47de-a59c-8c8f459be079,
  abstract     = {<p>Two gels have been found to be suitable to load with ferrous sulphate solution. In these soft tissue equivalent phantoms, the absorbed dose distribution can be measured after irradiation in clinically used MR imaging equipment. The present studies were carried out using a 0.25 T NMR analyser without imaging properties. A ferrous sulphate solution, 0.05 M with respect to sulphuric acid, can be gelled with 4% gelatin to give a dosemeter which has a response which is linearly correlated (r = 0.998) with the absorbed dose in the interval 0-40 Gy. Ferrous sulphate solution can also be gelled with 1% agarose, but this gel has to be purged with oxygen to obtain a linear relationship (r = 0.997) in the same absorbed dose interval. The ferrous sulphate loaded gels have a sensitivity which is a factor of 2.2 or 4.0 times higher for gelatin and agarose, respectively, than the ordinary dosemeter solution. Because the standard deviation of background measurements is higher for the gels than for the dosemeter solution, the minimum detectable absorbed dose is about the same, or 1.0 Gy, for the two gels and the dosemeter solution. The sensitivity of the ferrous sulphate loaded gels shows no dependence on dose rate if the mean dose rate and the absorbed dose per pulse are within the limits normally used by accelerators for radiotherapy.</p>},
  author       = {Olsson, L E and Petersson, J Stefan and Ahlgren, Lars and Mattsson, S},
  issn         = {0031-9155},
  keyword      = {Ferrous Compounds,Gels,In Vitro Techniques,Magnetic Resonance Imaging,Radiation Dosage},
  language     = {eng},
  number       = {1},
  pages        = {43--52},
  publisher    = {ARRAY(0xa04d9e0)},
  series       = {Physics in Medicine and Biology},
  title        = {Ferrous sulphate gels for determination of absorbed dose distributions using MRI technique : basic studies},
  url          = {http://dx.doi.org/10.1088/0031-9155/34/1/004},
  volume       = {34},
  year         = {1989},
}