Brain Tisue Response to Implanted SU-8
(2011) EEM820 20111Department of Biomedical Engineering
- Abstract
- Brain-machine interfaces are expected to play an important role in medicine – if a sustainable solution can be found – and so this study was performed to determine the biocompatibility of the photoresist SU-8 as well as a thin film needle design.This was done by histochemical staining with a collection of antibodies and mass spectrometry. The staining was performed on the perfused brains of four rats that had had cortical, contralateral implants for six weeks and of four rats with six week old stabwounds where the needle was retracted after two minutes. Histology showed a marked damage response in the controls as well as the implanted animals, implying that SU-8 affects the tissue in an unfavorable way, possibly by leaking into the... (More)
- Brain-machine interfaces are expected to play an important role in medicine – if a sustainable solution can be found – and so this study was performed to determine the biocompatibility of the photoresist SU-8 as well as a thin film needle design.This was done by histochemical staining with a collection of antibodies and mass spectrometry. The staining was performed on the perfused brains of four rats that had had cortical, contralateral implants for six weeks and of four rats with six week old stabwounds where the needle was retracted after two minutes. Histology showed a marked damage response in the controls as well as the implanted animals, implying that SU-8 affects the tissue in an unfavorable way, possibly by leaking into the surrounds of the implant. It may also be as a result of fragmentation of the material at retraction causing an implantation-like control series. The hypothesis of leakage is supported by mass spectrometry using MALDI-TOF MS that shows a noticeable amount of material leakage with masses separate from the used matrix. The amplification of GFAP in the controls on the other hand implythat the needle design causes a greater damage than expected. Gathered results heavily suggest that SU-8 needs a more extensive study to pinpoint wherein the trouble lies before one would be able to discard it as a possibility for future implants. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/2187834
- author
- Trobäck, Anette LU
- supervisor
-
- Lars Wallman LU
- organization
- course
- EEM820 20111
- year
- 2011
- type
- H2 - Master's Degree (Two Years)
- subject
- language
- English
- additional info
- 2011-06
- id
- 2187834
- date added to LUP
- 2011-10-24 13:21:38
- date last changed
- 2014-10-08 14:47:20
@misc{2187834,
abstract = {{Brain-machine interfaces are expected to play an important role in medicine – if a sustainable solution can be found – and so this study was performed to determine the biocompatibility of the photoresist SU-8 as well as a thin film needle design.This was done by histochemical staining with a collection of antibodies and mass spectrometry. The staining was performed on the perfused brains of four rats that had had cortical, contralateral implants for six weeks and of four rats with six week old stabwounds where the needle was retracted after two minutes. Histology showed a marked damage response in the controls as well as the implanted animals, implying that SU-8 affects the tissue in an unfavorable way, possibly by leaking into the surrounds of the implant. It may also be as a result of fragmentation of the material at retraction causing an implantation-like control series. The hypothesis of leakage is supported by mass spectrometry using MALDI-TOF MS that shows a noticeable amount of material leakage with masses separate from the used matrix. The amplification of GFAP in the controls on the other hand implythat the needle design causes a greater damage than expected. Gathered results heavily suggest that SU-8 needs a more extensive study to pinpoint wherein the trouble lies before one would be able to discard it as a possibility for future implants.}},
author = {{Trobäck, Anette}},
language = {{eng}},
note = {{Student Paper}},
title = {{Brain Tisue Response to Implanted SU-8}},
year = {{2011}},
}