The medial temporal lobe subregional atrophy in early onset and late onset amnestic variant Alzheimer’s disease
(2021) PSYP01 20211Department of Psychology
- Abstract
- Memory impairment and prominent hippocampal atrophy are the most recognisable features of Alzheimer’s disease (AD). It has been known that hippocampus and surrounding medial temporal lobe (MTL) structures support memory processes. However, specific function of each MTL subfield remains to be elucidated. Not all MTL subfields are uniformly affected by AD pathology and the spread of AD pathology follows a predictable pattern is closely correlated with atrophy seen on MRI and clinical symptoms. Hence, we propose that studying memory deficits in AD in tandem with MTL subfield atrophy might be fruitful to probe specific contribution of each MTL subfield to memory function. However, both clinical and anatomical heterogeneities have been reported... (More)
- Memory impairment and prominent hippocampal atrophy are the most recognisable features of Alzheimer’s disease (AD). It has been known that hippocampus and surrounding medial temporal lobe (MTL) structures support memory processes. However, specific function of each MTL subfield remains to be elucidated. Not all MTL subfields are uniformly affected by AD pathology and the spread of AD pathology follows a predictable pattern is closely correlated with atrophy seen on MRI and clinical symptoms. Hence, we propose that studying memory deficits in AD in tandem with MTL subfield atrophy might be fruitful to probe specific contribution of each MTL subfield to memory function. However, both clinical and anatomical heterogeneities have been reported in AD and age of onset is one source of heterogeneity. AD is commonly subdivided into early onset AD (EOAD = age of onset ≤ 65) and late onset AD (LOAD = age of onset > 65) and the two subtypes have several important clinical and anatomical differences. In order to probe the specific function of each MTL subregion by correlating the AD affected subregion and the corresponding cognitive deficit, we need to better characterise the topography of atrophy in AD patients. Therefore, the aim of this study is to investigate whether MTL subregional atrophy in EOAD and LOAD of amnestic type share similar topography. As atrophy patterns become less differentiated in the later stages of AD, in order to observe focal changes during early stages of AD, we also compared MTL subregional atrophy in a group with early onset mild cognitive impairment (EOMCI) and a group with late onset mild cognitive impairment (LOMCI) as mild cognitive impairment stage is proposed to be the precursor stage of AD. We found that all patient groups had varying degree of MTL subregional atrophy. Generally, current study found that differences in MTL subregional atrophy between EOAD and LOAD could be explained by age difference, possible TDP-43 co-pathology and higher tau burden in LOAD. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9067160
- author
- Wutt, Hmon LU
- supervisor
- organization
- course
- PSYP01 20211
- year
- 2021
- type
- H2 - Master's Degree (Two Years)
- subject
- keywords
- Medial temporal lobe subregional atrophy, Early onset AD vs late onset AD, Amnestic variant of AD
- language
- English
- id
- 9067160
- date added to LUP
- 2021-11-02 13:08:03
- date last changed
- 2021-11-02 13:08:03
@misc{9067160,
abstract = {{Memory impairment and prominent hippocampal atrophy are the most recognisable features of Alzheimer’s disease (AD). It has been known that hippocampus and surrounding medial temporal lobe (MTL) structures support memory processes. However, specific function of each MTL subfield remains to be elucidated. Not all MTL subfields are uniformly affected by AD pathology and the spread of AD pathology follows a predictable pattern is closely correlated with atrophy seen on MRI and clinical symptoms. Hence, we propose that studying memory deficits in AD in tandem with MTL subfield atrophy might be fruitful to probe specific contribution of each MTL subfield to memory function. However, both clinical and anatomical heterogeneities have been reported in AD and age of onset is one source of heterogeneity. AD is commonly subdivided into early onset AD (EOAD = age of onset ≤ 65) and late onset AD (LOAD = age of onset > 65) and the two subtypes have several important clinical and anatomical differences. In order to probe the specific function of each MTL subregion by correlating the AD affected subregion and the corresponding cognitive deficit, we need to better characterise the topography of atrophy in AD patients. Therefore, the aim of this study is to investigate whether MTL subregional atrophy in EOAD and LOAD of amnestic type share similar topography. As atrophy patterns become less differentiated in the later stages of AD, in order to observe focal changes during early stages of AD, we also compared MTL subregional atrophy in a group with early onset mild cognitive impairment (EOMCI) and a group with late onset mild cognitive impairment (LOMCI) as mild cognitive impairment stage is proposed to be the precursor stage of AD. We found that all patient groups had varying degree of MTL subregional atrophy. Generally, current study found that differences in MTL subregional atrophy between EOAD and LOAD could be explained by age difference, possible TDP-43 co-pathology and higher tau burden in LOAD.}},
author = {{Wutt, Hmon}},
language = {{eng}},
note = {{Student Paper}},
title = {{The medial temporal lobe subregional atrophy in early onset and late onset amnestic variant Alzheimer’s disease}},
year = {{2021}},
}