CoGenT++: an extensive and extensible data environment for computational genomics
(2005) In Bioinformatics 21(19). p.3806-3810- Abstract
- Motivation: CoGenT++ is a data environment for computational research in comparative and functional genomics, designed to address issues of consistency, reproducibility, scalability and accessibility.
Description: CoGenT++ facilitates the re-distribution of all fully sequenced and published genomes, storing information about species, gene names and protein sequences. We describe our scalable implementation of ProXSim, a continually updated all-against-all similarity database, which stores pairwise relationships between all genome sequences. Based on these similarities, derived databases are generated for gene fusions—AllFuse, putative orthologs—OFAM, protein families—TRIBES, phylogenetic profiles—ProfUse and... (More) - Motivation: CoGenT++ is a data environment for computational research in comparative and functional genomics, designed to address issues of consistency, reproducibility, scalability and accessibility.
Description: CoGenT++ facilitates the re-distribution of all fully sequenced and published genomes, storing information about species, gene names and protein sequences. We describe our scalable implementation of ProXSim, a continually updated all-against-all similarity database, which stores pairwise relationships between all genome sequences. Based on these similarities, derived databases are generated for gene fusions—AllFuse, putative orthologs—OFAM, protein families—TRIBES, phylogenetic profiles—ProfUse and phylogenetic trees. Extensions based on the CoGenT++ environment include disease gene prediction, pattern discovery, automated domain detection, genome annotation and ancestral reconstruction.
Conclusion: CoGenT++ provides a comprehensive environment for computational genomics, accessible primarily for large-scale analyses as well as manual browsing.
Availability: The database and component downloads are accessible at http://cgg.ebi.ac.uk/cogentpp.html.
Contact: ouzounis@ebi.ac.uk (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/952268
- author
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Bioinformatics
- volume
- 21
- issue
- 19
- pages
- 3806 - 3810
- publisher
- Oxford University Press
- external identifiers
-
- scopus:27544465780
- ISSN
- 1367-4803
- DOI
- 10.1093/bioinformatics/bti579
- language
- English
- LU publication?
- no
- id
- de944621-256e-4ee5-b0b9-ddc188060025 (old id 952268)
- date added to LUP
- 2016-04-01 12:16:10
- date last changed
- 2024-01-23 12:18:20
@article{de944621-256e-4ee5-b0b9-ddc188060025, abstract = {{Motivation: CoGenT++ is a data environment for computational research in comparative and functional genomics, designed to address issues of consistency, reproducibility, scalability and accessibility. <br/><br> <br/><br> Description: CoGenT++ facilitates the re-distribution of all fully sequenced and published genomes, storing information about species, gene names and protein sequences. We describe our scalable implementation of ProXSim, a continually updated all-against-all similarity database, which stores pairwise relationships between all genome sequences. Based on these similarities, derived databases are generated for gene fusions—AllFuse, putative orthologs—OFAM, protein families—TRIBES, phylogenetic profiles—ProfUse and phylogenetic trees. Extensions based on the CoGenT++ environment include disease gene prediction, pattern discovery, automated domain detection, genome annotation and ancestral reconstruction. <br/><br> <br/><br> Conclusion: CoGenT++ provides a comprehensive environment for computational genomics, accessible primarily for large-scale analyses as well as manual browsing. <br/><br> <br/><br> Availability: The database and component downloads are accessible at http://cgg.ebi.ac.uk/cogentpp.html. <br/><br> <br/><br> Contact: ouzounis@ebi.ac.uk}}, author = {{Goldovsky, Leon and Janssen, Paul and Ahrén, Dag and Audit, Benjamin and Cases, Ildefonso and Darzentas, Nikos and Enright, Anton and López-Bigas, Núria and Peregrin-Alvarez, José and Smith, Mike and Tsoka, Sophia and Kunin, Victor and Ouzounis, Christos}}, issn = {{1367-4803}}, language = {{eng}}, number = {{19}}, pages = {{3806--3810}}, publisher = {{Oxford University Press}}, series = {{Bioinformatics}}, title = {{CoGenT++: an extensive and extensible data environment for computational genomics}}, url = {{http://dx.doi.org/10.1093/bioinformatics/bti579}}, doi = {{10.1093/bioinformatics/bti579}}, volume = {{21}}, year = {{2005}}, }