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Sibling history is associated with heart failure after a first myocardial infarction

Glinge, Charlotte ; Oestergaard, Louise ; Jabbari, Reza ; Rossetti, Sara ; Skals, Regitze ; Køber, Lars ; Engstrøm, Thomas LU ; Bezzina, Connie R. ; Torp-Pedersen, Christian and Gislason, Gunnar , et al. (2020) In Open Heart 7(1).
Abstract

Objective: Morbidity and mortality due to heart failure (HF) as a complication of myocardial infarction (MI) is high, and remains among the leading causes of death and hospitalisation. This study investigated the association between family history of MI with or without HF, and the risk of developing HF after first MI. Methods: Through nationwide registries, we identified all individuals aged 18-50 years hospitalised with first MI from 1997 to 2016 in Denmark. We identified 13 810 patients with MI, and the cohort was followed until HF diagnosis, second MI, 3 years after index MI, emigration, death or the end of 2016, whichever occurred first. HRs were estimated by Cox hazard regression models adjusted for sex, age, calendar year and... (More)

Objective: Morbidity and mortality due to heart failure (HF) as a complication of myocardial infarction (MI) is high, and remains among the leading causes of death and hospitalisation. This study investigated the association between family history of MI with or without HF, and the risk of developing HF after first MI. Methods: Through nationwide registries, we identified all individuals aged 18-50 years hospitalised with first MI from 1997 to 2016 in Denmark. We identified 13 810 patients with MI, and the cohort was followed until HF diagnosis, second MI, 3 years after index MI, emigration, death or the end of 2016, whichever occurred first. HRs were estimated by Cox hazard regression models adjusted for sex, age, calendar year and comorbidities (reference: patients with no family history of MI). Results: After adjustment, we observed an increased risk of MI-induced HF for those having a sibling with MI with HF (HR 2.05, 95% CI 1.02 to 4.12). Those having a sibling with MI without HF also had a significant, but lower increased risk of HF (HR 1.39, 95% CI 1.05 to 1.84). Parental history of MI with or without HF was not associated with HF. Conclusion: In this nationwide cohort, sibling history of MI with or without HF was associated with increased risk of HF after first MI, while a parental family history was not, suggesting that shared environmental factors may predominate in the determination of risk for developing HF.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
family history, heart failure, myocardial ischaemia and infarction (IHD)
in
Open Heart
volume
7
issue
1
article number
e001143
publisher
BMJ Publishing Group
external identifiers
  • pmid:32257244
  • scopus:85082617242
ISSN
2398-595X
DOI
10.1136/openhrt-2019-001143
language
English
LU publication?
yes
id
006a4d47-2f12-43c6-bf04-bf357e70584d
date added to LUP
2020-04-20 16:57:57
date last changed
2024-04-03 06:18:33
@article{006a4d47-2f12-43c6-bf04-bf357e70584d,
  abstract     = {{<p>Objective: Morbidity and mortality due to heart failure (HF) as a complication of myocardial infarction (MI) is high, and remains among the leading causes of death and hospitalisation. This study investigated the association between family history of MI with or without HF, and the risk of developing HF after first MI. Methods: Through nationwide registries, we identified all individuals aged 18-50 years hospitalised with first MI from 1997 to 2016 in Denmark. We identified 13 810 patients with MI, and the cohort was followed until HF diagnosis, second MI, 3 years after index MI, emigration, death or the end of 2016, whichever occurred first. HRs were estimated by Cox hazard regression models adjusted for sex, age, calendar year and comorbidities (reference: patients with no family history of MI). Results: After adjustment, we observed an increased risk of MI-induced HF for those having a sibling with MI with HF (HR 2.05, 95% CI 1.02 to 4.12). Those having a sibling with MI without HF also had a significant, but lower increased risk of HF (HR 1.39, 95% CI 1.05 to 1.84). Parental history of MI with or without HF was not associated with HF. Conclusion: In this nationwide cohort, sibling history of MI with or without HF was associated with increased risk of HF after first MI, while a parental family history was not, suggesting that shared environmental factors may predominate in the determination of risk for developing HF.</p>}},
  author       = {{Glinge, Charlotte and Oestergaard, Louise and Jabbari, Reza and Rossetti, Sara and Skals, Regitze and Køber, Lars and Engstrøm, Thomas and Bezzina, Connie R. and Torp-Pedersen, Christian and Gislason, Gunnar and Tfelt-Hansen, Jacob}},
  issn         = {{2398-595X}},
  keywords     = {{family history; heart failure; myocardial ischaemia and infarction (IHD)}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{1}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Open Heart}},
  title        = {{Sibling history is associated with heart failure after a first myocardial infarction}},
  url          = {{http://dx.doi.org/10.1136/openhrt-2019-001143}},
  doi          = {{10.1136/openhrt-2019-001143}},
  volume       = {{7}},
  year         = {{2020}},
}