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Clinical relevance of positive patch test reactions to lanolin : A ROAT study

Uldahl, Ada LU ; Engfeldt, Malin LU and Svedman, Cecilia LU (2021) In Contact Dermatitis 84(1). p.41-49
Abstract

Background: Lanolin is often included when patch testing for common contact allergens. The clinical relevance of a positive patch test reaction to lanolin markers is, however, still a subject for debate. Objectives: To evaluate Amerchol L101 as a marker of lanolin allergy and investigate the clinical impact of lanolin-containing moisturizers on healthy and damaged skin using the repeated open application test (ROAT). Methods: Twelve test subjects and 14 controls were patch tested with Amerchol L 101 and additional lanolin markers. Subsequently, a blinded ROAT was performed on the arms of the study participants for 4 weeks. Each participant applied a lanolin-free cream base and two different lanolin-containing test creams twice daily on... (More)

Background: Lanolin is often included when patch testing for common contact allergens. The clinical relevance of a positive patch test reaction to lanolin markers is, however, still a subject for debate. Objectives: To evaluate Amerchol L101 as a marker of lanolin allergy and investigate the clinical impact of lanolin-containing moisturizers on healthy and damaged skin using the repeated open application test (ROAT). Methods: Twelve test subjects and 14 controls were patch tested with Amerchol L 101 and additional lanolin markers. Subsequently, a blinded ROAT was performed on the arms of the study participants for 4 weeks. Each participant applied a lanolin-free cream base and two different lanolin-containing test creams twice daily on one arm with intact skin and on the other arm with irritant dermatitis, induced by sodium lauryl sulfate (SLS). Results: Eleven test subjects (92%) had positive patch test reactions to Amerchol L 101 when retested and one test subject (8%) had a doubtful reaction. None of the study participants had any skin reactions to the ROAT on intact skin and all participants healed during the ROAT on damaged skin. Conclusions: Lanolin-containing emollients do not cause or worsen existing dermatitis when performing ROAT in volunteers patch test positive to Amerchol L101.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, Amerchol L101, CAS no. 8027-33-6, emollient, lanolin, patch testing, relevance, repeated open application test
in
Contact Dermatitis
volume
84
issue
1
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85092064317
  • pmid:32844454
ISSN
0105-1873
DOI
10.1111/cod.13689
language
English
LU publication?
yes
id
00c012ea-0da1-4fc3-9c56-030dc250a6b0
date added to LUP
2020-11-06 15:22:11
date last changed
2024-06-12 23:18:30
@article{00c012ea-0da1-4fc3-9c56-030dc250a6b0,
  abstract     = {{<p>Background: Lanolin is often included when patch testing for common contact allergens. The clinical relevance of a positive patch test reaction to lanolin markers is, however, still a subject for debate. Objectives: To evaluate Amerchol L101 as a marker of lanolin allergy and investigate the clinical impact of lanolin-containing moisturizers on healthy and damaged skin using the repeated open application test (ROAT). Methods: Twelve test subjects and 14 controls were patch tested with Amerchol L 101 and additional lanolin markers. Subsequently, a blinded ROAT was performed on the arms of the study participants for 4 weeks. Each participant applied a lanolin-free cream base and two different lanolin-containing test creams twice daily on one arm with intact skin and on the other arm with irritant dermatitis, induced by sodium lauryl sulfate (SLS). Results: Eleven test subjects (92%) had positive patch test reactions to Amerchol L 101 when retested and one test subject (8%) had a doubtful reaction. None of the study participants had any skin reactions to the ROAT on intact skin and all participants healed during the ROAT on damaged skin. Conclusions: Lanolin-containing emollients do not cause or worsen existing dermatitis when performing ROAT in volunteers patch test positive to Amerchol L101.</p>}},
  author       = {{Uldahl, Ada and Engfeldt, Malin and Svedman, Cecilia}},
  issn         = {{0105-1873}},
  keywords     = {{allergic contact dermatitis, Amerchol L101, CAS no. 8027-33-6, emollient, lanolin, patch testing, relevance, repeated open application test}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{41--49}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Clinical relevance of positive patch test reactions to lanolin : A ROAT study}},
  url          = {{http://dx.doi.org/10.1111/cod.13689}},
  doi          = {{10.1111/cod.13689}},
  volume       = {{84}},
  year         = {{2021}},
}