Clinical relevance of positive patch test reactions to lanolin : A ROAT study
(2021) In Contact Dermatitis 84(1). p.41-49- Abstract
Background: Lanolin is often included when patch testing for common contact allergens. The clinical relevance of a positive patch test reaction to lanolin markers is, however, still a subject for debate. Objectives: To evaluate Amerchol L101 as a marker of lanolin allergy and investigate the clinical impact of lanolin-containing moisturizers on healthy and damaged skin using the repeated open application test (ROAT). Methods: Twelve test subjects and 14 controls were patch tested with Amerchol L 101 and additional lanolin markers. Subsequently, a blinded ROAT was performed on the arms of the study participants for 4 weeks. Each participant applied a lanolin-free cream base and two different lanolin-containing test creams twice daily on... (More)
Background: Lanolin is often included when patch testing for common contact allergens. The clinical relevance of a positive patch test reaction to lanolin markers is, however, still a subject for debate. Objectives: To evaluate Amerchol L101 as a marker of lanolin allergy and investigate the clinical impact of lanolin-containing moisturizers on healthy and damaged skin using the repeated open application test (ROAT). Methods: Twelve test subjects and 14 controls were patch tested with Amerchol L 101 and additional lanolin markers. Subsequently, a blinded ROAT was performed on the arms of the study participants for 4 weeks. Each participant applied a lanolin-free cream base and two different lanolin-containing test creams twice daily on one arm with intact skin and on the other arm with irritant dermatitis, induced by sodium lauryl sulfate (SLS). Results: Eleven test subjects (92%) had positive patch test reactions to Amerchol L 101 when retested and one test subject (8%) had a doubtful reaction. None of the study participants had any skin reactions to the ROAT on intact skin and all participants healed during the ROAT on damaged skin. Conclusions: Lanolin-containing emollients do not cause or worsen existing dermatitis when performing ROAT in volunteers patch test positive to Amerchol L101.
(Less)
- author
- Uldahl, Ada LU ; Engfeldt, Malin LU and Svedman, Cecilia LU
- organization
- publishing date
- 2021-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- allergic contact dermatitis, Amerchol L101, CAS no. 8027-33-6, emollient, lanolin, patch testing, relevance, repeated open application test
- in
- Contact Dermatitis
- volume
- 84
- issue
- 1
- pages
- 9 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:32844454
- scopus:85092064317
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.13689
- language
- English
- LU publication?
- yes
- id
- 00c012ea-0da1-4fc3-9c56-030dc250a6b0
- date added to LUP
- 2020-11-06 15:22:11
- date last changed
- 2024-09-06 06:32:00
@article{00c012ea-0da1-4fc3-9c56-030dc250a6b0, abstract = {{<p>Background: Lanolin is often included when patch testing for common contact allergens. The clinical relevance of a positive patch test reaction to lanolin markers is, however, still a subject for debate. Objectives: To evaluate Amerchol L101 as a marker of lanolin allergy and investigate the clinical impact of lanolin-containing moisturizers on healthy and damaged skin using the repeated open application test (ROAT). Methods: Twelve test subjects and 14 controls were patch tested with Amerchol L 101 and additional lanolin markers. Subsequently, a blinded ROAT was performed on the arms of the study participants for 4 weeks. Each participant applied a lanolin-free cream base and two different lanolin-containing test creams twice daily on one arm with intact skin and on the other arm with irritant dermatitis, induced by sodium lauryl sulfate (SLS). Results: Eleven test subjects (92%) had positive patch test reactions to Amerchol L 101 when retested and one test subject (8%) had a doubtful reaction. None of the study participants had any skin reactions to the ROAT on intact skin and all participants healed during the ROAT on damaged skin. Conclusions: Lanolin-containing emollients do not cause or worsen existing dermatitis when performing ROAT in volunteers patch test positive to Amerchol L101.</p>}}, author = {{Uldahl, Ada and Engfeldt, Malin and Svedman, Cecilia}}, issn = {{0105-1873}}, keywords = {{allergic contact dermatitis, Amerchol L101, CAS no. 8027-33-6, emollient, lanolin, patch testing, relevance, repeated open application test}}, language = {{eng}}, number = {{1}}, pages = {{41--49}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Clinical relevance of positive patch test reactions to lanolin : A ROAT study}}, url = {{http://dx.doi.org/10.1111/cod.13689}}, doi = {{10.1111/cod.13689}}, volume = {{84}}, year = {{2021}}, }