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Hypocretin Deficiency Develops During Onset of Human Narcolepsy with Cataplexy

Savvidou, Andri ; Knudsen, Stine ; Olsson-Engman, Mia ; Gammeltoft, Steen ; Jennum, Poul and Palm, Lars LU (2013) In Sleep 36(1). p.147-148
Abstract
Study Objectives: Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. Setting: Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. Patient and Results: Two weeks after his second Pandemrix-vaccination, a 10 year old HLA-DQB1*0602-positive boy developed NC. The CSF hypocretin-1 level was 10 pg/ml. However, CSF saved from a pre-narcolepsy episode of Lyme disease revealed a normal hypocretin-1 level (318 pg/ml). Conclusions: We confirm that hypocretin deficiency develops in parallel to the onset of human narcolepsy with cataplexy.
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
H1N1, hypocretin deficiency, narcolepsy
in
Sleep
volume
36
issue
1
pages
147 - 148
publisher
Oxford University Press
external identifiers
  • wos:000313001200020
  • scopus:84871891987
ISSN
0161-8105
DOI
10.5665/sleep.2320
language
English
LU publication?
yes
id
00c16043-b257-4062-b10c-bd14102bdccb (old id 3481361)
date added to LUP
2016-04-01 10:17:13
date last changed
2025-10-14 13:19:32
@article{00c16043-b257-4062-b10c-bd14102bdccb,
  abstract     = {{Study Objectives: Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. Setting: Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. Patient and Results: Two weeks after his second Pandemrix-vaccination, a 10 year old HLA-DQB1*0602-positive boy developed NC. The CSF hypocretin-1 level was 10 pg/ml. However, CSF saved from a pre-narcolepsy episode of Lyme disease revealed a normal hypocretin-1 level (318 pg/ml). Conclusions: We confirm that hypocretin deficiency develops in parallel to the onset of human narcolepsy with cataplexy.}},
  author       = {{Savvidou, Andri and Knudsen, Stine and Olsson-Engman, Mia and Gammeltoft, Steen and Jennum, Poul and Palm, Lars}},
  issn         = {{0161-8105}},
  keywords     = {{H1N1; hypocretin deficiency; narcolepsy}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{147--148}},
  publisher    = {{Oxford University Press}},
  series       = {{Sleep}},
  title        = {{Hypocretin Deficiency Develops During Onset of Human Narcolepsy with Cataplexy}},
  url          = {{http://dx.doi.org/10.5665/sleep.2320}},
  doi          = {{10.5665/sleep.2320}},
  volume       = {{36}},
  year         = {{2013}},
}