Hypocretin Deficiency Develops During Onset of Human Narcolepsy with Cataplexy
(2013) In Sleep 36(1). p.147-148- Abstract
- Study Objectives: Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. Setting: Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. Patient and Results: Two weeks after his second Pandemrix-vaccination, a 10 year old HLA-DQB1*0602-positive boy developed NC. The CSF hypocretin-1 level was 10 pg/ml. However, CSF saved from a pre-narcolepsy episode of Lyme disease revealed a normal hypocretin-1 level (318 pg/ml). Conclusions: We confirm that hypocretin deficiency develops in parallel to the onset of human narcolepsy with cataplexy.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3481361
- author
- Savvidou, Andri ; Knudsen, Stine ; Olsson-Engman, Mia ; Gammeltoft, Steen ; Jennum, Poul and Palm, Lars LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- H1N1, hypocretin deficiency, narcolepsy
- in
- Sleep
- volume
- 36
- issue
- 1
- pages
- 147 - 148
- publisher
- Oxford University Press
- external identifiers
-
- wos:000313001200020
- scopus:84871891987
- ISSN
- 0161-8105
- DOI
- 10.5665/sleep.2320
- language
- English
- LU publication?
- yes
- id
- 00c16043-b257-4062-b10c-bd14102bdccb (old id 3481361)
- date added to LUP
- 2016-04-01 10:17:13
- date last changed
- 2022-01-25 21:44:59
@article{00c16043-b257-4062-b10c-bd14102bdccb, abstract = {{Study Objectives: Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. Setting: Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. Patient and Results: Two weeks after his second Pandemrix-vaccination, a 10 year old HLA-DQB1*0602-positive boy developed NC. The CSF hypocretin-1 level was 10 pg/ml. However, CSF saved from a pre-narcolepsy episode of Lyme disease revealed a normal hypocretin-1 level (318 pg/ml). Conclusions: We confirm that hypocretin deficiency develops in parallel to the onset of human narcolepsy with cataplexy.}}, author = {{Savvidou, Andri and Knudsen, Stine and Olsson-Engman, Mia and Gammeltoft, Steen and Jennum, Poul and Palm, Lars}}, issn = {{0161-8105}}, keywords = {{H1N1; hypocretin deficiency; narcolepsy}}, language = {{eng}}, number = {{1}}, pages = {{147--148}}, publisher = {{Oxford University Press}}, series = {{Sleep}}, title = {{Hypocretin Deficiency Develops During Onset of Human Narcolepsy with Cataplexy}}, url = {{http://dx.doi.org/10.5665/sleep.2320}}, doi = {{10.5665/sleep.2320}}, volume = {{36}}, year = {{2013}}, }