Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Interaction of leisure-time physical activity with body mass index on the risk of obesity-related cancers : A pooled study

Sun, Ming LU ; Bjørge, Tone LU ; Teleka, Stanley LU ; Engeland, Anders ; Wennberg, Patrik ; Häggström, Christel LU and Stocks, Tanja LU (2022) In International Journal of Cancer 151(6). p.859-868
Abstract

Physical activity (PA) has been associated with a lower risk of some obesity-related cancers, but the combined association and interaction of PA and body weight on obesity-related cancer risk is less clear. We examined the association of leisure-time PA (high/low) and its combination with body mass index (BMI, <25 [low]/≥25 [high] kg/m2) on obesity-related cancer risk in 570 021 individuals, aged 43 years on average at baseline, in five Scandinavian cohorts. We used Cox regression to calculate hazard ratios of obesity-related cancers (n = 19 074) and assessed multiplicative and additive interactions between PA and BMI on risk. High leisure-time PA, recorded in 19% of the individuals, was associated with a 7% (95%... (More)

Physical activity (PA) has been associated with a lower risk of some obesity-related cancers, but the combined association and interaction of PA and body weight on obesity-related cancer risk is less clear. We examined the association of leisure-time PA (high/low) and its combination with body mass index (BMI, <25 [low]/≥25 [high] kg/m2) on obesity-related cancer risk in 570 021 individuals, aged 43 years on average at baseline, in five Scandinavian cohorts. We used Cox regression to calculate hazard ratios of obesity-related cancers (n = 19 074) and assessed multiplicative and additive interactions between PA and BMI on risk. High leisure-time PA, recorded in 19% of the individuals, was associated with a 7% (95% confidence interval [CI] 4%-10%) lower risk of any obesity-related cancer compared to low PA, with similar associations amongst individuals with a low and a high BMI (6% [1%-11%] and 7% [2%-11%]). High PA was also associated with decreased risks of renal cell (11% [9%-31%]) and colon cancer (9% [2%-16%]). When high PA and low BMI were combined, the relative risk reduction for all obesity-related cancers was 24% (95% CI 20%-28%); endometrial cancer, 47% (35%-57%); renal cell cancer, 39% (27%-51%); colon cancer, 27% (19%-35%); multiple myeloma, 23% (2%-40%) and pancreatic cancer, 21% (4%-35%), compared to low PA-high BMI. There were no additive or multiplicative interactions between PA and BMI on risk. The result of our study suggests a reduced risk of obesity-related cancer by leisure-time PA in both normal weight and overweight individuals, which further decreased for PA and normal weight combined.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
body mass index, interaction, leisure-time physical activity, obesity-related cancer
in
International Journal of Cancer
volume
151
issue
6
pages
859 - 868
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85128579162
  • pmid:35362551
ISSN
0020-7136
DOI
10.1002/ijc.34011
language
English
LU publication?
yes
id
011908a3-c5aa-43a0-8f3b-7bc0ff382082
date added to LUP
2022-07-05 11:50:36
date last changed
2024-06-25 21:28:47
@article{011908a3-c5aa-43a0-8f3b-7bc0ff382082,
  abstract     = {{<p>Physical activity (PA) has been associated with a lower risk of some obesity-related cancers, but the combined association and interaction of PA and body weight on obesity-related cancer risk is less clear. We examined the association of leisure-time PA (high/low) and its combination with body mass index (BMI, &lt;25 [low]/≥25 [high] kg/m<sup>2</sup>) on obesity-related cancer risk in 570 021 individuals, aged 43 years on average at baseline, in five Scandinavian cohorts. We used Cox regression to calculate hazard ratios of obesity-related cancers (n = 19 074) and assessed multiplicative and additive interactions between PA and BMI on risk. High leisure-time PA, recorded in 19% of the individuals, was associated with a 7% (95% confidence interval [CI] 4%-10%) lower risk of any obesity-related cancer compared to low PA, with similar associations amongst individuals with a low and a high BMI (6% [1%-11%] and 7% [2%-11%]). High PA was also associated with decreased risks of renal cell (11% [9%-31%]) and colon cancer (9% [2%-16%]). When high PA and low BMI were combined, the relative risk reduction for all obesity-related cancers was 24% (95% CI 20%-28%); endometrial cancer, 47% (35%-57%); renal cell cancer, 39% (27%-51%); colon cancer, 27% (19%-35%); multiple myeloma, 23% (2%-40%) and pancreatic cancer, 21% (4%-35%), compared to low PA-high BMI. There were no additive or multiplicative interactions between PA and BMI on risk. The result of our study suggests a reduced risk of obesity-related cancer by leisure-time PA in both normal weight and overweight individuals, which further decreased for PA and normal weight combined.</p>}},
  author       = {{Sun, Ming and Bjørge, Tone and Teleka, Stanley and Engeland, Anders and Wennberg, Patrik and Häggström, Christel and Stocks, Tanja}},
  issn         = {{0020-7136}},
  keywords     = {{body mass index; interaction; leisure-time physical activity; obesity-related cancer}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{859--868}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Interaction of leisure-time physical activity with body mass index on the risk of obesity-related cancers : A pooled study}},
  url          = {{http://dx.doi.org/10.1002/ijc.34011}},
  doi          = {{10.1002/ijc.34011}},
  volume       = {{151}},
  year         = {{2022}},
}