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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

Chubb, Daniel; Weinhold, Niels; Broderick, Peter; Chen, Bowang; Johnson, David C.; Försti, Asta LU ; Vijayakrishnan, Jayaram; Migliorini, Gabriele; Dobbins, Sara E. and Holroyd, Amy, et al. (2013) In Nature Genetics 45(10). p.366-1221
Abstract
To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 x 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 x 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 x 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 x 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.
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@article{0130c0d9-1d4a-48b1-86f1-1f9070f7de4e,
  abstract     = {To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 x 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 x 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 x 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 x 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.},
  author       = {Chubb, Daniel and Weinhold, Niels and Broderick, Peter and Chen, Bowang and Johnson, David C. and Försti, Asta and Vijayakrishnan, Jayaram and Migliorini, Gabriele and Dobbins, Sara E. and Holroyd, Amy and Hose, Dirk and Walker, Brian A. and Davies, Faith E. and Gregory, Walter A. and Jackson, Graham H. and Irving, Julie A. and Pratt, Guy and Fegan, Chris and Fenton, James A. L. and Neben, Kai and Hoffmann, Per and Noethen, Markus M. and Muehleisen, Thomas W. and Eisele, Lewin and Ross, Fiona M. and Straka, Christian and Einsele, Hermann and Langer, Christian and Doerner, Elisabeth and Allan, James M. and Jauch, Anna and Morgan, Gareth J. and Hemminki, Kari and Houlston, Richard S. and Goldschmidt, Hartmut},
  issn         = {1546-1718},
  language     = {eng},
  number       = {10},
  pages        = {366--1221},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk},
  url          = {http://dx.doi.org/10.1038/ng.2733},
  volume       = {45},
  year         = {2013},
}