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Serological markers for human intestinal ischemia : A systematic review

Derikx, Joep P M; Schellekens, Dirk H S M and Acosta, Stefan LU (2017) In Bailliere's Best Practice and Research in Clinical Gastroenterology
Abstract

Early and accurate diagnosis of intestinal ischemia is important in order to provide rapid and correct treatment and reduce morbidity and mortality rates. Clinical signs and symptoms are often unspecific. This systemic review sums up literature regarding human plasma biomarkers for acute mesenteric ischemia reported during the last ten years. Classic, general markers, including lactate, white cell count, base excess, show poor diagnostic accuracy for intestinal ischemia. Preliminary results for ischemia-modified albumin are promising, which is also true for the inflammatory marker procalcitonin. Best diagnostic accuracy is described for D-dimer, a-Glutathione S-transferase (a-GST) and Intestinal fatty acid binding protein (I-FABP),... (More)

Early and accurate diagnosis of intestinal ischemia is important in order to provide rapid and correct treatment and reduce morbidity and mortality rates. Clinical signs and symptoms are often unspecific. This systemic review sums up literature regarding human plasma biomarkers for acute mesenteric ischemia reported during the last ten years. Classic, general markers, including lactate, white cell count, base excess, show poor diagnostic accuracy for intestinal ischemia. Preliminary results for ischemia-modified albumin are promising, which is also true for the inflammatory marker procalcitonin. Best diagnostic accuracy is described for D-dimer, a-Glutathione S-transferase (a-GST) and Intestinal fatty acid binding protein (I-FABP), reflecting coagulation activity and mucosal damage respectively. Future studies should be directed at phase four questions (Do patients who undergo the diagnostic test fare better (in their ultimate health outcomes) than similar patients who do not?) for these markers and the identification of additional, novel plasma biomarkers signaling various types and stages of intestinal ischemia.

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author
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Diagnosis, Intestinal ischemia, Plasma biomarkers
in
Bailliere's Best Practice and Research in Clinical Gastroenterology
publisher
Baillière Tindall
external identifiers
  • scopus:85013637500
ISSN
1521-6918
DOI
10.1016/j.bpg.2017.01.004
language
English
LU publication?
no
id
016d84ff-6262-4bd4-a0ef-326ef86c6c7b
date added to LUP
2017-03-15 15:12:57
date last changed
2017-06-15 03:00:20
@article{016d84ff-6262-4bd4-a0ef-326ef86c6c7b,
  abstract     = {<p>Early and accurate diagnosis of intestinal ischemia is important in order to provide rapid and correct treatment and reduce morbidity and mortality rates. Clinical signs and symptoms are often unspecific. This systemic review sums up literature regarding human plasma biomarkers for acute mesenteric ischemia reported during the last ten years. Classic, general markers, including lactate, white cell count, base excess, show poor diagnostic accuracy for intestinal ischemia. Preliminary results for ischemia-modified albumin are promising, which is also true for the inflammatory marker procalcitonin. Best diagnostic accuracy is described for D-dimer, a-Glutathione S-transferase (a-GST) and Intestinal fatty acid binding protein (I-FABP), reflecting coagulation activity and mucosal damage respectively. Future studies should be directed at phase four questions (Do patients who undergo the diagnostic test fare better (in their ultimate health outcomes) than similar patients who do not?) for these markers and the identification of additional, novel plasma biomarkers signaling various types and stages of intestinal ischemia.</p>},
  author       = {Derikx, Joep P M and Schellekens, Dirk H S M and Acosta, Stefan},
  issn         = {1521-6918},
  keyword      = {Diagnosis,Intestinal ischemia,Plasma biomarkers},
  language     = {eng},
  publisher    = {Baillière Tindall},
  series       = {Bailliere's Best Practice and Research in Clinical Gastroenterology},
  title        = {Serological markers for human intestinal ischemia : A systematic review},
  url          = {http://dx.doi.org/10.1016/j.bpg.2017.01.004},
  year         = {2017},
}