Monkeypox virus-associated meningoencephalitis diagnosed by detection of intrathecal antibody production
Karin, Hansen LU ; Ylva, Båtshake ; Sandra, Söderholm ; Aleksandra, Pettke ; Per, Björkman LU
and Klara, Sondén
(2024)
In BMC Infectious Diseases
24(1).
- Abstract
Background: In the 2022 mpox-outbreak most patients presented with mild symptoms. Central nervous system (CNS) involvement has previously been described as a rare and severe complication of mpox; however, diagnostic findings in cerebrospinal fluid (CSF) analysis and neuroimaging studies have only been reported in one case previously. Case presentation: We report a previously healthy 37-year-old man with mpox complicated by encephalitis. He first presented with painful skin lesions and genital ulcers; polymerase chain reaction (PCR) from the lesions was positive for mpox. Twelve days later he was admitted with fever and confusion. Neuroimaging and CSF analysis indicated encephalitis. The CSF was PCR-negative for monkeypox virus but... (More)
Background: In the 2022 mpox-outbreak most patients presented with mild symptoms. Central nervous system (CNS) involvement has previously been described as a rare and severe complication of mpox; however, diagnostic findings in cerebrospinal fluid (CSF) analysis and neuroimaging studies have only been reported in one case previously. Case presentation: We report a previously healthy 37-year-old man with mpox complicated by encephalitis. He first presented with painful skin lesions and genital ulcers; polymerase chain reaction (PCR) from the lesions was positive for mpox. Twelve days later he was admitted with fever and confusion. Neuroimaging and CSF analysis indicated encephalitis. The CSF was PCR-negative for monkeypox virus but intrathecal antibody production was detected. He spontaneously improved over a few days course and recovered fully. Conclusions: This case of mpox-associated encephalitis shows that CNS involvement in mpox infection may have a relatively mild clinical course, and that detection of intrathecal antibody production can be used to establish the diagnosis if CSF monkeypox virus-PCR is negative.
(Less)
- author
- Karin, Hansen
LU
; Ylva, Båtshake
; Sandra, Söderholm
; Aleksandra, Pettke
; Per, Björkman
LU
and Klara, Sondén
- organization
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CNS complication, Encephalitis, Monkeypox virus, Mpox, PCR, Serology
- in
- BMC Infectious Diseases
- volume
- 24
- issue
- 1
- article number
- 94
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:38229022
- scopus:85182423433
- ISSN
- 1471-2334
- DOI
- 10.1186/s12879-024-09000-0
- language
- English
- LU publication?
- yes
- id
- 017ae00e-bf3c-4419-bdbc-7699643020ee
- date added to LUP
- 2024-02-16 15:40:07
- date last changed
- 2024-04-17 09:26:10
@article{017ae00e-bf3c-4419-bdbc-7699643020ee,
abstract = {{<p>Background: In the 2022 mpox-outbreak most patients presented with mild symptoms. Central nervous system (CNS) involvement has previously been described as a rare and severe complication of mpox; however, diagnostic findings in cerebrospinal fluid (CSF) analysis and neuroimaging studies have only been reported in one case previously. Case presentation: We report a previously healthy 37-year-old man with mpox complicated by encephalitis. He first presented with painful skin lesions and genital ulcers; polymerase chain reaction (PCR) from the lesions was positive for mpox. Twelve days later he was admitted with fever and confusion. Neuroimaging and CSF analysis indicated encephalitis. The CSF was PCR-negative for monkeypox virus but intrathecal antibody production was detected. He spontaneously improved over a few days course and recovered fully. Conclusions: This case of mpox-associated encephalitis shows that CNS involvement in mpox infection may have a relatively mild clinical course, and that detection of intrathecal antibody production can be used to establish the diagnosis if CSF monkeypox virus-PCR is negative.</p>}},
author = {{Karin, Hansen and Ylva, Båtshake and Sandra, Söderholm and Aleksandra, Pettke and Per, Björkman and Klara, Sondén}},
issn = {{1471-2334}},
keywords = {{CNS complication; Encephalitis; Monkeypox virus; Mpox; PCR; Serology}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Infectious Diseases}},
title = {{Monkeypox virus-associated meningoencephalitis diagnosed by detection of intrathecal antibody production}},
url = {{http://dx.doi.org/10.1186/s12879-024-09000-0}},
doi = {{10.1186/s12879-024-09000-0}},
volume = {{24}},
year = {{2024}},
}