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Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations

Reis, Margareta LU ; Aberg-Wistedt, A ; Agren, H ; Akerblad, AC and Bengtsson, F (2004) In Journal of Affective Disorders 82(3). p.443-446
Abstract
Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood. Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated... (More)
Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood. Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated metabolite/parent compound ratio measurements. Result: 9.4% of the per-protocol population in the trial (n = 96) were in either hidden total (n = 4) or hidden partial (n = 5) noncompliance. Only by using the novel TDM ratio screening method could a majority of these patients be identified. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sertraline, SSRI, depression
in
Journal of Affective Disorders
volume
82
issue
3
pages
443 - 446
publisher
Elsevier
external identifiers
  • pmid:15555696
  • wos:000225850600013
  • scopus:8844283451
ISSN
1573-2517
DOI
10.1016/j.jad.2004.02.003
language
English
LU publication?
yes
id
0195f53d-e423-44c9-9a26-e0fa03ee4b0c (old id 258484)
date added to LUP
2016-04-01 11:41:33
date last changed
2022-01-26 08:50:28
@article{0195f53d-e423-44c9-9a26-e0fa03ee4b0c,
  abstract     = {{Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood. Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated metabolite/parent compound ratio measurements. Result: 9.4% of the per-protocol population in the trial (n = 96) were in either hidden total (n = 4) or hidden partial (n = 5) noncompliance. Only by using the novel TDM ratio screening method could a majority of these patients be identified.}},
  author       = {{Reis, Margareta and Aberg-Wistedt, A and Agren, H and Akerblad, AC and Bengtsson, F}},
  issn         = {{1573-2517}},
  keywords     = {{sertraline; SSRI; depression}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{443--446}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Affective Disorders}},
  title        = {{Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations}},
  url          = {{http://dx.doi.org/10.1016/j.jad.2004.02.003}},
  doi          = {{10.1016/j.jad.2004.02.003}},
  volume       = {{82}},
  year         = {{2004}},
}