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Selected biomarkers correlate with the origin and severity of sepsis

Holub, Michal ; Dupová, Olga ; Ruková, Michaela ; Stráníková, Alzbeta ; Bartáková, Eva ; Máca, Jan ; Bene, Jirí ; Herwald, Heiko LU orcid and Beran, Ondrej (2018) In Mediators of Inflammation 2018.
Abstract

The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18). Next, cortisol levels were higher in IE patients than... (More)

The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mediators of Inflammation
volume
2018
article number
7028267
publisher
Hindawi Limited
external identifiers
  • scopus:85054088798
  • pmid:29769838
ISSN
0962-9351
DOI
10.1155/2018/7028267
language
English
LU publication?
yes
id
01b327a4-615e-4005-9ed8-89c8dcb46013
date added to LUP
2018-10-29 12:47:24
date last changed
2021-10-06 05:43:57
@article{01b327a4-615e-4005-9ed8-89c8dcb46013,
  abstract     = {<p>The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.</p>},
  author       = {Holub, Michal and Dupová, Olga and Ruková, Michaela and Stráníková, Alzbeta and Bartáková, Eva and Máca, Jan and Bene, Jirí and Herwald, Heiko and Beran, Ondrej},
  issn         = {0962-9351},
  language     = {eng},
  month        = {03},
  publisher    = {Hindawi Limited},
  series       = {Mediators of Inflammation},
  title        = {Selected biomarkers correlate with the origin and severity of sepsis},
  url          = {http://dx.doi.org/10.1155/2018/7028267},
  doi          = {10.1155/2018/7028267},
  volume       = {2018},
  year         = {2018},
}