Selected biomarkers correlate with the origin and severity of sepsis
Holub, Michal ; Dupová, Olga ; Ruková, Michaela ; Stráníková, Alzbeta ; Bartáková, Eva ; Máca, Jan ; Bene, Jirí ; Herwald, Heiko LU
and Beran, Ondrej
(2018)
In Mediators of Inflammation
2018.
- Abstract
The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18). Next, cortisol levels were higher in IE patients than... (More)
The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.
(Less)
- author
- Holub, Michal
; Dupová, Olga
; Ruková, Michaela
; Stráníková, Alzbeta
; Bartáková, Eva
; Máca, Jan
; Bene, Jirí
; Herwald, Heiko
LU
and Beran, Ondrej
- organization
- publishing date
- 2018-03-27
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Mediators of Inflammation
- volume
- 2018
- article number
- 7028267
- publisher
- Hindawi Limited
- external identifiers
-
- scopus:85054088798
- pmid:29769838
- ISSN
- 0962-9351
- DOI
- 10.1155/2018/7028267
- language
- English
- LU publication?
- yes
- id
- 01b327a4-615e-4005-9ed8-89c8dcb46013
- date added to LUP
- 2018-10-29 12:47:24
- date last changed
- 2024-04-15 15:09:08
@article{01b327a4-615e-4005-9ed8-89c8dcb46013,
abstract = {{<p>The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.</p>}},
author = {{Holub, Michal and Dupová, Olga and Ruková, Michaela and Stráníková, Alzbeta and Bartáková, Eva and Máca, Jan and Bene, Jirí and Herwald, Heiko and Beran, Ondrej}},
issn = {{0962-9351}},
language = {{eng}},
month = {{03}},
publisher = {{Hindawi Limited}},
series = {{Mediators of Inflammation}},
title = {{Selected biomarkers correlate with the origin and severity of sepsis}},
url = {{http://dx.doi.org/10.1155/2018/7028267}},
doi = {{10.1155/2018/7028267}},
volume = {{2018}},
year = {{2018}},
}