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Nrf2 activation and downstream effects : Focus on parkinson’s disease and brain angiotensin

Parga, Juan A. ; Rodriguez-Perez, Ana I. ; Garcia-Garrote, Maria LU orcid ; Rodriguez-Pallares, Jannette and Labandeira-Garcia, Jose L. (2021) In Antioxidants 10(11). p.1-23
Abstract

Reactive oxygen species (ROS) are signalling molecules used to regulate cellular metabolism and homeostasis. However, excessive ROS production causes oxidative stress, one of the main mechanisms associated with the origin and progression of neurodegenerative disorders such as Parkinson’s disease. NRF2 (Nuclear Factor-Erythroid 2 Like 2) is a transcription factor that or-chestrates the cellular response to oxidative stress. The regulation of NRF2 signalling has been shown to be a promising strategy to modulate the progression of the neurodegeneration associated to Parkinson’s disease. The NRF2 pathway has been shown to be affected in patients with this disease, and activation of NRF2 has neuroprotective effects in preclinical models,... (More)

Reactive oxygen species (ROS) are signalling molecules used to regulate cellular metabolism and homeostasis. However, excessive ROS production causes oxidative stress, one of the main mechanisms associated with the origin and progression of neurodegenerative disorders such as Parkinson’s disease. NRF2 (Nuclear Factor-Erythroid 2 Like 2) is a transcription factor that or-chestrates the cellular response to oxidative stress. The regulation of NRF2 signalling has been shown to be a promising strategy to modulate the progression of the neurodegeneration associated to Parkinson’s disease. The NRF2 pathway has been shown to be affected in patients with this disease, and activation of NRF2 has neuroprotective effects in preclinical models, demonstrating the therapeutic potential of this pathway. In this review, we highlight recent advances regarding the regulation of NRF2, including the effect of Angiotensin II as an endogenous signalling molecule able to regulate ROS production and oxidative stress in dopaminergic neurons. The genes regulated and the downstream effects of activation, with special focus on Kruppel Like Factor 9 (KLF9) transcription factor, provide clues about the mechanisms involved in the neurodegenerative process as well as future therapeutic approaches.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Antioxidant, Heme oxygenase, KLF9, Neurodegeneration, NRF2, Parkinson’s disease, Redox signalling, Renin–angiotensin system
in
Antioxidants
volume
10
issue
11
article number
1649
pages
1 - 23
publisher
MDPI AG
external identifiers
  • scopus:85117301127
ISSN
2076-3921
DOI
10.3390/antiox10111649
language
English
LU publication?
no
additional info
Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
id
01c68d06-83eb-40dc-9e46-7d1bd32514fa
date added to LUP
2025-01-24 11:52:25
date last changed
2025-01-24 12:41:39
@article{01c68d06-83eb-40dc-9e46-7d1bd32514fa,
  abstract     = {{<p>Reactive oxygen species (ROS) are signalling molecules used to regulate cellular metabolism and homeostasis. However, excessive ROS production causes oxidative stress, one of the main mechanisms associated with the origin and progression of neurodegenerative disorders such as Parkinson’s disease. NRF2 (Nuclear Factor-Erythroid 2 Like 2) is a transcription factor that or-chestrates the cellular response to oxidative stress. The regulation of NRF2 signalling has been shown to be a promising strategy to modulate the progression of the neurodegeneration associated to Parkinson’s disease. The NRF2 pathway has been shown to be affected in patients with this disease, and activation of NRF2 has neuroprotective effects in preclinical models, demonstrating the therapeutic potential of this pathway. In this review, we highlight recent advances regarding the regulation of NRF2, including the effect of Angiotensin II as an endogenous signalling molecule able to regulate ROS production and oxidative stress in dopaminergic neurons. The genes regulated and the downstream effects of activation, with special focus on Kruppel Like Factor 9 (KLF9) transcription factor, provide clues about the mechanisms involved in the neurodegenerative process as well as future therapeutic approaches.</p>}},
  author       = {{Parga, Juan A. and Rodriguez-Perez, Ana I. and Garcia-Garrote, Maria and Rodriguez-Pallares, Jannette and Labandeira-Garcia, Jose L.}},
  issn         = {{2076-3921}},
  keywords     = {{Antioxidant; Heme oxygenase; KLF9; Neurodegeneration; NRF2; Parkinson’s disease; Redox signalling; Renin–angiotensin system}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1--23}},
  publisher    = {{MDPI AG}},
  series       = {{Antioxidants}},
  title        = {{Nrf2 activation and downstream effects : Focus on parkinson’s disease and brain angiotensin}},
  url          = {{http://dx.doi.org/10.3390/antiox10111649}},
  doi          = {{10.3390/antiox10111649}},
  volume       = {{10}},
  year         = {{2021}},
}