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7. In vivo quantification of glutathione T2 in the human brain at 7 Tesla using echo time extension with variable refocusing selectivity and symmetry

Swanberg, Kelley LU orcid ; Prinsen, Hetty ; Coman, Daniel ; Rothman, Douglas L. ; DeGraaf, Robin A. and Juchem, Christoph (2017) 2017.
Abstract
The tripeptide glutathione (L-γ-glutamyl-L-cysteinyl glycine or GSH) is an endogenous antioxidant implicated in many neurological conditions, including multiple sclerosis. Its precise quantification by proton magnetic resonance spectroscopy is, however, hampered by its uncertain T2. Here, we present a method for the quantification of GSH T2 in the human brain at 7 Tesla using optimized echo time extension delays and variable refocusing selectivity and symmetry to maximize the intensity and specificity of J-difference-edited GSH signals predicted by a full density matrix description of signal behavior. Using this method, we measured a GSH T2 of 144.2 ± 5.5 ms that is considerably shorter than that calculated for either of two common... (More)
The tripeptide glutathione (L-γ-glutamyl-L-cysteinyl glycine or GSH) is an endogenous antioxidant implicated in many neurological conditions, including multiple sclerosis. Its precise quantification by proton magnetic resonance spectroscopy is, however, hampered by its uncertain T2. Here, we present a method for the quantification of GSH T2 in the human brain at 7 Tesla using optimized echo time extension delays and variable refocusing selectivity and symmetry to maximize the intensity and specificity of J-difference-edited GSH signals predicted by a full density matrix description of signal behavior. Using this method, we measured a GSH T2 of 144.2 ± 5.5 ms that is considerably shorter than that calculated for either of two common reference metabolites NAA (221.9 ± 10.3 ms) or creatine (155.3 ± 5.9 ms), emphasizing the importance of considering T2 relaxation differences in the spectroscopic measurement of these metabolites at long echo times. (Less)
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Chapter in Book/Report/Conference proceeding
publication status
published
host publication
Proc Int Soc Magn Reson Med
volume
2017
language
English
LU publication?
no
id
01c6d310-61f9-4500-9ce3-715a693aede8
alternative location
https://archive.ismrm.org/2017/3000.html
date added to LUP
2023-09-18 15:59:34
date last changed
2023-09-19 12:35:01
@inproceedings{01c6d310-61f9-4500-9ce3-715a693aede8,
  abstract     = {{The tripeptide glutathione (L-γ-glutamyl-L-cysteinyl glycine or GSH) is an endogenous antioxidant implicated in many neurological conditions, including multiple sclerosis. Its precise quantification by proton magnetic resonance spectroscopy is, however, hampered by its uncertain T2. Here, we present a method for the quantification of GSH T2 in the human brain at 7 Tesla using optimized echo time extension delays and variable refocusing selectivity and symmetry to maximize the intensity and specificity of J-difference-edited GSH signals predicted by a full density matrix description of signal behavior. Using this method, we measured a GSH T2 of 144.2 ± 5.5 ms that is considerably shorter than that calculated for either of two common reference metabolites NAA (221.9 ± 10.3 ms) or creatine (155.3 ± 5.9 ms), emphasizing the importance of considering T2 relaxation differences in the spectroscopic measurement of these metabolites at long echo times.}},
  author       = {{Swanberg, Kelley and Prinsen, Hetty and Coman, Daniel and Rothman, Douglas L. and DeGraaf, Robin A. and Juchem, Christoph}},
  booktitle    = {{Proc Int Soc Magn Reson Med}},
  language     = {{eng}},
  title        = {{7. In vivo quantification of glutathione T2 in the human brain at 7 Tesla using echo time extension with variable refocusing selectivity and symmetry}},
  url          = {{https://archive.ismrm.org/2017/3000.html}},
  volume       = {{2017}},
  year         = {{2017}},
}