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γ 2‐MSH increases during graded exercise in healthy subjects : comparison with plasma catecholamines, neuropeptides, aldosterone and renin activity

Valdemarsson, S. LU ; Andersson, D. LU ; Bengtsson, A. LU ; Bogren, M. LU ; Edvinsson, L. LU and Ekman, R. (1990) In Clinical Physiology 10(4). p.321-327
Abstract

Summary. To evaluate the possibility that the proopiomelanocortin (POMC)‐derived peptide γ2‐melanocyte stimulating hormone (γ2‐MSH) has a role in circulatory regulation in man we studied circulating levels of this peptide at three different stages of physical activity in 10 young healthy subjects. The results were compared to simultaneously measured plasma levels of catecholamines, neuropeptide Y, vasopressin, renin activity, aldosterone and human α‐atrial natriuretic peptide (α‐hANP) and of the vasodilatory peptides calcitonin gene‐related peptide, substance P and vasoactive intestinal peptide. The plasma levels of γ2‐MSH‐LI (like immunoreactivity) increased from 1009 ± 101 pmol 1‐1 at... (More)

Summary. To evaluate the possibility that the proopiomelanocortin (POMC)‐derived peptide γ2‐melanocyte stimulating hormone (γ2‐MSH) has a role in circulatory regulation in man we studied circulating levels of this peptide at three different stages of physical activity in 10 young healthy subjects. The results were compared to simultaneously measured plasma levels of catecholamines, neuropeptide Y, vasopressin, renin activity, aldosterone and human α‐atrial natriuretic peptide (α‐hANP) and of the vasodilatory peptides calcitonin gene‐related peptide, substance P and vasoactive intestinal peptide. The plasma levels of γ2‐MSH‐LI (like immunoreactivity) increased from 1009 ± 101 pmol 1‐1 at supine rest to 1281 ± 79 pmol 1‐1 when measured after 10 min walking (P<0·05), and remained at this increased level also after a consecutive further increase of physical activity (4 min stair rush), 1293 ± 87 pmol 1‐1 (P<0·05 vs. at rest). The increase in circulating γ2‐MSH‐LI levels preceded the elevation of the venous plasma noradrenaline level, but did not rise further with more pronounced activation of the sympathetic nervous system at the highest grade of physical activity examined.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atrial natriuretic peptide, blood pressure regulation, calcitonin gene‐related peptide, neuropeptide Y, physical exercise, substance P, vasopressin
in
Clinical Physiology
volume
10
issue
4
pages
7 pages
publisher
Wiley Online Library
external identifiers
  • pmid:2203597
  • scopus:0025144426
ISSN
0144-5979
DOI
10.1111/j.1475-097X.1990.tb00793.x
language
English
LU publication?
no
id
01d47dc9-de89-4fc6-a956-b82eb0ef22e0
date added to LUP
2019-05-23 10:47:51
date last changed
2020-01-13 01:53:33
@article{01d47dc9-de89-4fc6-a956-b82eb0ef22e0,
  abstract     = {<p>Summary.  To evaluate the possibility that the proopiomelanocortin (POMC)‐derived peptide γ<sub>2</sub>‐melanocyte stimulating hormone (γ<sub>2</sub>‐MSH) has a role in circulatory regulation in man we studied circulating levels of this peptide at three different stages of physical activity in 10 young healthy subjects. The results were compared to simultaneously measured plasma levels of catecholamines, neuropeptide Y, vasopressin, renin activity, aldosterone and human α‐atrial natriuretic peptide (α‐hANP) and of the vasodilatory peptides calcitonin gene‐related peptide, substance P and vasoactive intestinal peptide. The plasma levels of γ<sub>2</sub>‐MSH‐LI (like immunoreactivity) increased from 1009 ± 101 pmol 1<sup>‐1</sup> at supine rest to 1281 ± 79 pmol 1<sup>‐1</sup> when measured after 10 min walking (P&lt;0·05), and remained at this increased level also after a consecutive further increase of physical activity (4 min stair rush), 1293 ± 87 pmol 1<sup>‐1</sup> (P&lt;0·05 vs. at rest). The increase in circulating γ<sub>2</sub>‐MSH‐LI levels preceded the elevation of the venous plasma noradrenaline level, but did not rise further with more pronounced activation of the sympathetic nervous system at the highest grade of physical activity examined.</p>},
  author       = {Valdemarsson, S. and Andersson, D. and Bengtsson, A. and Bogren, M. and Edvinsson, L. and Ekman, R.},
  issn         = {0144-5979},
  language     = {eng},
  month        = {01},
  number       = {4},
  pages        = {321--327},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology},
  title        = {γ               <sub>2</sub>‐MSH increases during graded exercise in healthy subjects : comparison with plasma catecholamines, neuropeptides, aldosterone and renin activity},
  url          = {http://dx.doi.org/10.1111/j.1475-097X.1990.tb00793.x},
  doi          = {10.1111/j.1475-097X.1990.tb00793.x},
  volume       = {10},
  year         = {1990},
}