Surgery for patients with primary hyperparathyroidism and negative sestamibi scintigraphy--a feasibility study
(2009) In Langenbeck's Archives of Surgery 394(5). p.4-881- Abstract
BACKGROUND: We report the surgical treatment of a consecutive series of scan negative patients with the intention of unilateral parathyroid exploration with the aid of intraoperative quick PTH (qPTH).
MATERIALS AND METHODS: The study included 35 consecutive sestamibi scan negative patients (27 women, eight men) with sporadic pHPT subjected to first time surgery. Median age was 70 years and median preoperative calcium level 2.8 mmol/L.
RESULTS: Thirty-three patients had a histological diagnosis of a parathyroid adenoma (median weight 0.48 g [range 0.12 g-2.5 g]). Nineteen patients were explored bilaterally and 16 patients (46%) were operated unilaterally. The median operation time was 40 min in the unilateral group and 95 min... (More)
BACKGROUND: We report the surgical treatment of a consecutive series of scan negative patients with the intention of unilateral parathyroid exploration with the aid of intraoperative quick PTH (qPTH).
MATERIALS AND METHODS: The study included 35 consecutive sestamibi scan negative patients (27 women, eight men) with sporadic pHPT subjected to first time surgery. Median age was 70 years and median preoperative calcium level 2.8 mmol/L.
RESULTS: Thirty-three patients had a histological diagnosis of a parathyroid adenoma (median weight 0.48 g [range 0.12 g-2.5 g]). Nineteen patients were explored bilaterally and 16 patients (46%) were operated unilaterally. The median operation time was 40 min in the unilateral group and 95 min in the bilateral group (p < 0.001). Three patients were treated for postoperative hypocalcemia after bilateral exploration versus none in the unilateral group (p = 0.23). With a minimum of 12 months of follow-up, 33 patients (94.3%) were cured. One case of recurrent HPT presented after bilateral exploration with visualization of four glands. One case of persistent HPT was observed after unilateral exploration. qPTH was predictive of operative failure in both patients.
CONCLUSION: Forty-six percent of the patients in our study could be operated unilaterally with a total cure rate of 94%. Patients in the unilateral group had a significant shorter operation time and a lower incidence of postoperative hypocalcemia. In conclusion our investigation shows that limited parathyroid exploration can safely be performed on patients with negative sestamibi scintigraphy by the aid of qPTH.
(Less)
- author
- Thier, Mark LU ; Nordenström, Erik LU ; Bergenfelz, Anders LU and Westerdahl, Johan LU
- organization
- publishing date
- 2009-09
- type
- Contribution to journal
- publication status
- published
- keywords
- Adenoma, Adult, Aged, Aged, 80 and over, Feasibility Studies, Female, Humans, Hyperparathyroidism, Primary, Male, Middle Aged, Parathyroid Glands, Parathyroid Neoplasms, Parathyroidectomy, Radiopharmaceuticals, Technetium Tc 99m Sestamibi
- in
- Langenbeck's Archives of Surgery
- volume
- 394
- issue
- 5
- pages
- 4 pages
- publisher
- Springer
- external identifiers
-
- pmid:19547996
- scopus:68649099651
- ISSN
- 1435-2451
- DOI
- 10.1007/s00423-009-0524-6
- language
- English
- LU publication?
- yes
- id
- 02146bb0-1ea4-4b92-8900-a9ce59865213
- date added to LUP
- 2016-04-27 16:08:27
- date last changed
- 2025-01-12 00:45:44
@article{02146bb0-1ea4-4b92-8900-a9ce59865213, abstract = {{<p>BACKGROUND: We report the surgical treatment of a consecutive series of scan negative patients with the intention of unilateral parathyroid exploration with the aid of intraoperative quick PTH (qPTH).</p><p>MATERIALS AND METHODS: The study included 35 consecutive sestamibi scan negative patients (27 women, eight men) with sporadic pHPT subjected to first time surgery. Median age was 70 years and median preoperative calcium level 2.8 mmol/L.</p><p>RESULTS: Thirty-three patients had a histological diagnosis of a parathyroid adenoma (median weight 0.48 g [range 0.12 g-2.5 g]). Nineteen patients were explored bilaterally and 16 patients (46%) were operated unilaterally. The median operation time was 40 min in the unilateral group and 95 min in the bilateral group (p < 0.001). Three patients were treated for postoperative hypocalcemia after bilateral exploration versus none in the unilateral group (p = 0.23). With a minimum of 12 months of follow-up, 33 patients (94.3%) were cured. One case of recurrent HPT presented after bilateral exploration with visualization of four glands. One case of persistent HPT was observed after unilateral exploration. qPTH was predictive of operative failure in both patients.</p><p>CONCLUSION: Forty-six percent of the patients in our study could be operated unilaterally with a total cure rate of 94%. Patients in the unilateral group had a significant shorter operation time and a lower incidence of postoperative hypocalcemia. In conclusion our investigation shows that limited parathyroid exploration can safely be performed on patients with negative sestamibi scintigraphy by the aid of qPTH.</p>}}, author = {{Thier, Mark and Nordenström, Erik and Bergenfelz, Anders and Westerdahl, Johan}}, issn = {{1435-2451}}, keywords = {{Adenoma; Adult; Aged; Aged, 80 and over; Feasibility Studies; Female; Humans; Hyperparathyroidism, Primary; Male; Middle Aged; Parathyroid Glands; Parathyroid Neoplasms; Parathyroidectomy; Radiopharmaceuticals; Technetium Tc 99m Sestamibi}}, language = {{eng}}, number = {{5}}, pages = {{4--881}}, publisher = {{Springer}}, series = {{Langenbeck's Archives of Surgery}}, title = {{Surgery for patients with primary hyperparathyroidism and negative sestamibi scintigraphy--a feasibility study}}, url = {{http://dx.doi.org/10.1007/s00423-009-0524-6}}, doi = {{10.1007/s00423-009-0524-6}}, volume = {{394}}, year = {{2009}}, }