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ABO blood group and the risk of aortic disease : a nationwide cohort study

Zindovic, Igor LU ; Edgren, Gustaf ; Nozohoor, Shahab LU and Majeed, Ammar (2020) In BMJ Open 10(10).
Abstract

OBJECTIVES: To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden. DESIGN: This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and presented as incidence rate ratios (IRRs). SETTING: Swedish population-based study. PARTICIPANTS: The study cohort consisted of 1 164 561 Swedish blood donors and 961 637 transfused patients with a combined follow-up time of 29 390 649 person-years. PRIMARY AND SECONDARY OUTCOME MEASURES: IRRs of aortic events (ie, aortic aneurysms and/or aortic... (More)

OBJECTIVES: To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden. DESIGN: This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and presented as incidence rate ratios (IRRs). SETTING: Swedish population-based study. PARTICIPANTS: The study cohort consisted of 1 164 561 Swedish blood donors and 961 637 transfused patients with a combined follow-up time of 29 390 649 person-years. PRIMARY AND SECONDARY OUTCOME MEASURES: IRRs of aortic events (ie, aortic aneurysms and/or aortic dissections) in relation to patient blood group. RESULTS: A total of 20 684 aortic events occurred during the study period. Non-O donors and patients had similar incidence of aortic events when compared with blood group O donors and patients with an IRR of 0.98 (95% CI, 0.93-1.04) and 1.00 (95% CI, 0.97-1.03), respectively. There were no differences between non-O and blood group O individuals when aortic dissections and aortic aneurysms were analysed separately. Blood group B conferred a lower risk of aortic aneurysms in the patient cohort when compared with blood group O (IRR, 0.90; 95% CI, 0.85-0.96). CONCLUSIONS: In the present study, there were no statistically significant associations between ABO blood group and the risk of aortic disease. A possible protective effect of blood group B was observed in the patient cohort but this finding requires further investigation.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bleeding disorders & coagulopathies, epidemiology, thoracic surgery
in
BMJ Open
volume
10
issue
10
article number
e036040
publisher
BMJ Publishing Group
external identifiers
  • scopus:85092525051
  • pmid:33004386
ISSN
2044-6055
DOI
10.1136/bmjopen-2019-036040
language
English
LU publication?
yes
id
0252bde7-e924-4b22-bd28-b05deebfacfc
date added to LUP
2021-01-26 16:00:29
date last changed
2024-06-27 08:50:10
@article{0252bde7-e924-4b22-bd28-b05deebfacfc,
  abstract     = {{<p>OBJECTIVES: To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden. DESIGN: This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and presented as incidence rate ratios (IRRs). SETTING: Swedish population-based study. PARTICIPANTS: The study cohort consisted of 1 164 561 Swedish blood donors and 961 637 transfused patients with a combined follow-up time of 29 390 649 person-years. PRIMARY AND SECONDARY OUTCOME MEASURES: IRRs of aortic events (ie, aortic aneurysms and/or aortic dissections) in relation to patient blood group. RESULTS: A total of 20 684 aortic events occurred during the study period. Non-O donors and patients had similar incidence of aortic events when compared with blood group O donors and patients with an IRR of 0.98 (95% CI, 0.93-1.04) and 1.00 (95% CI, 0.97-1.03), respectively. There were no differences between non-O and blood group O individuals when aortic dissections and aortic aneurysms were analysed separately. Blood group B conferred a lower risk of aortic aneurysms in the patient cohort when compared with blood group O (IRR, 0.90; 95% CI, 0.85-0.96). CONCLUSIONS: In the present study, there were no statistically significant associations between ABO blood group and the risk of aortic disease. A possible protective effect of blood group B was observed in the patient cohort but this finding requires further investigation.</p>}},
  author       = {{Zindovic, Igor and Edgren, Gustaf and Nozohoor, Shahab and Majeed, Ammar}},
  issn         = {{2044-6055}},
  keywords     = {{bleeding disorders & coagulopathies; epidemiology; thoracic surgery}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{ABO blood group and the risk of aortic disease : a nationwide cohort study}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2019-036040}},
  doi          = {{10.1136/bmjopen-2019-036040}},
  volume       = {{10}},
  year         = {{2020}},
}