ABO blood group and the risk of aortic disease : a nationwide cohort study
(2020) In BMJ Open 10(10).- Abstract
OBJECTIVES: To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden. DESIGN: This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and presented as incidence rate ratios (IRRs). SETTING: Swedish population-based study. PARTICIPANTS: The study cohort consisted of 1 164 561 Swedish blood donors and 961 637 transfused patients with a combined follow-up time of 29 390 649 person-years. PRIMARY AND SECONDARY OUTCOME MEASURES: IRRs of aortic events (ie, aortic aneurysms and/or aortic... (More)
OBJECTIVES: To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden. DESIGN: This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and presented as incidence rate ratios (IRRs). SETTING: Swedish population-based study. PARTICIPANTS: The study cohort consisted of 1 164 561 Swedish blood donors and 961 637 transfused patients with a combined follow-up time of 29 390 649 person-years. PRIMARY AND SECONDARY OUTCOME MEASURES: IRRs of aortic events (ie, aortic aneurysms and/or aortic dissections) in relation to patient blood group. RESULTS: A total of 20 684 aortic events occurred during the study period. Non-O donors and patients had similar incidence of aortic events when compared with blood group O donors and patients with an IRR of 0.98 (95% CI, 0.93-1.04) and 1.00 (95% CI, 0.97-1.03), respectively. There were no differences between non-O and blood group O individuals when aortic dissections and aortic aneurysms were analysed separately. Blood group B conferred a lower risk of aortic aneurysms in the patient cohort when compared with blood group O (IRR, 0.90; 95% CI, 0.85-0.96). CONCLUSIONS: In the present study, there were no statistically significant associations between ABO blood group and the risk of aortic disease. A possible protective effect of blood group B was observed in the patient cohort but this finding requires further investigation.
(Less)
- author
- Zindovic, Igor LU ; Edgren, Gustaf ; Nozohoor, Shahab LU and Majeed, Ammar
- organization
- publishing date
- 2020-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bleeding disorders & coagulopathies, epidemiology, thoracic surgery
- in
- BMJ Open
- volume
- 10
- issue
- 10
- article number
- e036040
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:85092525051
- pmid:33004386
- ISSN
- 2044-6055
- DOI
- 10.1136/bmjopen-2019-036040
- language
- English
- LU publication?
- yes
- id
- 0252bde7-e924-4b22-bd28-b05deebfacfc
- date added to LUP
- 2021-01-26 16:00:29
- date last changed
- 2024-04-04 00:07:36
@article{0252bde7-e924-4b22-bd28-b05deebfacfc, abstract = {{<p>OBJECTIVES: To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden. DESIGN: This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and presented as incidence rate ratios (IRRs). SETTING: Swedish population-based study. PARTICIPANTS: The study cohort consisted of 1 164 561 Swedish blood donors and 961 637 transfused patients with a combined follow-up time of 29 390 649 person-years. PRIMARY AND SECONDARY OUTCOME MEASURES: IRRs of aortic events (ie, aortic aneurysms and/or aortic dissections) in relation to patient blood group. RESULTS: A total of 20 684 aortic events occurred during the study period. Non-O donors and patients had similar incidence of aortic events when compared with blood group O donors and patients with an IRR of 0.98 (95% CI, 0.93-1.04) and 1.00 (95% CI, 0.97-1.03), respectively. There were no differences between non-O and blood group O individuals when aortic dissections and aortic aneurysms were analysed separately. Blood group B conferred a lower risk of aortic aneurysms in the patient cohort when compared with blood group O (IRR, 0.90; 95% CI, 0.85-0.96). CONCLUSIONS: In the present study, there were no statistically significant associations between ABO blood group and the risk of aortic disease. A possible protective effect of blood group B was observed in the patient cohort but this finding requires further investigation.</p>}}, author = {{Zindovic, Igor and Edgren, Gustaf and Nozohoor, Shahab and Majeed, Ammar}}, issn = {{2044-6055}}, keywords = {{bleeding disorders & coagulopathies; epidemiology; thoracic surgery}}, language = {{eng}}, month = {{10}}, number = {{10}}, publisher = {{BMJ Publishing Group}}, series = {{BMJ Open}}, title = {{ABO blood group and the risk of aortic disease : a nationwide cohort study}}, url = {{http://dx.doi.org/10.1136/bmjopen-2019-036040}}, doi = {{10.1136/bmjopen-2019-036040}}, volume = {{10}}, year = {{2020}}, }