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Clinical and biochemical presentation of sarcoidosis with high and normal serum angiotensin-converting enzyme

Sejdic, A LU ; Graudal, N and Baslund, B (2018) In Scandinavian Journal of Rheumatology 47(6). p.487-490
Abstract

OBJECTIVES: The presentation of sarcoidosis can involve symptoms from all organs and the diagnosis is therefore often difficult. A raised serum level of serum angiotensin-converting enzyme (sACE) can be detected in 41-58% of patients. However, whether the sACE level per se reflects the severity of the sarcoid inflammation at the onset of the disease is not well described. The purpose of this study was to investigate the clinical and laboratory significance of high versus normal sACE levels in sarcoidosis.

METHOD: Journal data were retrospectively extracted from 101 patients from our clinic. Clinical and biochemical data were compared between patients with high sACE levels (> 115 U/L) on at least one occasion and normal sACE... (More)

OBJECTIVES: The presentation of sarcoidosis can involve symptoms from all organs and the diagnosis is therefore often difficult. A raised serum level of serum angiotensin-converting enzyme (sACE) can be detected in 41-58% of patients. However, whether the sACE level per se reflects the severity of the sarcoid inflammation at the onset of the disease is not well described. The purpose of this study was to investigate the clinical and laboratory significance of high versus normal sACE levels in sarcoidosis.

METHOD: Journal data were retrospectively extracted from 101 patients from our clinic. Clinical and biochemical data were compared between patients with high sACE levels (> 115 U/L) on at least one occasion and normal sACE levels (< 115 U/L).

RESULTS: In total, 48% (n = 48) of the patients had high ACE and 52% (n = 53) had normal ACE. The most common extrapulmonary manifestation for both groups was arthritis, followed by skin and eye involvement, but none of these differed between the two groups. Serum ionized calcium was significantly higher in the high sACE group, with a correlation coefficient of 0.112 (p = 0.460).

CONCLUSION: Our study demonstrates that serum ionized calcium is significantly higher in the high sACE group but there was no statistical correlation to sACE. No other clinical or biochemical differences were observed.

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author
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Denmark, Female, Humans, Infant, Male, Middle Aged, Peptidyl-Dipeptidase A/blood, Retrospective Studies, Sarcoidosis/blood, Young Adult
in
Scandinavian Journal of Rheumatology
volume
47
issue
6
pages
487 - 490
publisher
Taylor & Francis
external identifiers
  • pmid:29929412
  • scopus:85048884009
ISSN
1502-7732
DOI
10.1080/03009742.2017.1420818
language
English
LU publication?
no
id
0257a052-7592-4227-aa85-58294d5e0ff2
date added to LUP
2024-10-14 09:28:04
date last changed
2025-04-04 15:07:54
@article{0257a052-7592-4227-aa85-58294d5e0ff2,
  abstract     = {{<p>OBJECTIVES: The presentation of sarcoidosis can involve symptoms from all organs and the diagnosis is therefore often difficult. A raised serum level of serum angiotensin-converting enzyme (sACE) can be detected in 41-58% of patients. However, whether the sACE level per se reflects the severity of the sarcoid inflammation at the onset of the disease is not well described. The purpose of this study was to investigate the clinical and laboratory significance of high versus normal sACE levels in sarcoidosis.</p><p>METHOD: Journal data were retrospectively extracted from 101 patients from our clinic. Clinical and biochemical data were compared between patients with high sACE levels (&gt; 115 U/L) on at least one occasion and normal sACE levels (&lt; 115 U/L).</p><p>RESULTS: In total, 48% (n = 48) of the patients had high ACE and 52% (n = 53) had normal ACE. The most common extrapulmonary manifestation for both groups was arthritis, followed by skin and eye involvement, but none of these differed between the two groups. Serum ionized calcium was significantly higher in the high sACE group, with a correlation coefficient of 0.112 (p = 0.460).</p><p>CONCLUSION: Our study demonstrates that serum ionized calcium is significantly higher in the high sACE group but there was no statistical correlation to sACE. No other clinical or biochemical differences were observed.</p>}},
  author       = {{Sejdic, A and Graudal, N and Baslund, B}},
  issn         = {{1502-7732}},
  keywords     = {{Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Denmark; Female; Humans; Infant; Male; Middle Aged; Peptidyl-Dipeptidase A/blood; Retrospective Studies; Sarcoidosis/blood; Young Adult}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{487--490}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Rheumatology}},
  title        = {{Clinical and biochemical presentation of sarcoidosis with high and normal serum angiotensin-converting enzyme}},
  url          = {{http://dx.doi.org/10.1080/03009742.2017.1420818}},
  doi          = {{10.1080/03009742.2017.1420818}},
  volume       = {{47}},
  year         = {{2018}},
}