An inter-day assessment of the ABC parameters in the evaluation of progressive keratoconus
(2021) In Scientific Reports 11(1).- Abstract
The progression of keratoconus is commonly determined by comparing the results of corneal tomographic measurements on different occasions. However, investigations on the repeatability of measurements are commonly performed within the same day, thus not taking the inter-day variation into account. The effect of keratoconus disease severity on the measurement error is also seldom considered. In this post hoc investigation, the parameters A, B and C in the Belin ABCD Progression Display were evaluated in relation to disease severity in intra-day and inter-day measurements. Four consecutive measurements were performed on 61 patients with keratoconus on the same day (intra-day). In another cohort, four consecutive measurements were obtained... (More)
The progression of keratoconus is commonly determined by comparing the results of corneal tomographic measurements on different occasions. However, investigations on the repeatability of measurements are commonly performed within the same day, thus not taking the inter-day variation into account. The effect of keratoconus disease severity on the measurement error is also seldom considered. In this post hoc investigation, the parameters A, B and C in the Belin ABCD Progression Display were evaluated in relation to disease severity in intra-day and inter-day measurements. Four consecutive measurements were performed on 61 patients with keratoconus on the same day (intra-day). In another cohort, four consecutive measurements were obtained and then repeated 3 days later in 25 patients with keratoconus and 25 healthy controls (inter-day). The results suggest that the diagnosis of disease progression would benefit from inter-day measurements, and the stratification of the parameters A and C according to disease severity. It is also recommended that tomographic systems such as the Pentacam HR be modified to allow the comparison of both single measurements and the mean of replicate measurements of the parameters used in the assessment of progression of keratoconus.
(Less)
- author
- Gustafsson, Ingemar LU ; Faxén, Tove LU ; Vicente, André LU ; Bergström, Anders LU ; Ivarsen, Anders and Hjortdal, Jesper Østergaard
- organization
- publishing date
- 2021-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 11
- issue
- 1
- article number
- 16037
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:34362986
- scopus:85112618064
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-021-95503-8
- language
- English
- LU publication?
- yes
- id
- 02aaad5b-0e69-4c84-89ca-38236137e9e1
- date added to LUP
- 2021-09-06 09:19:44
- date last changed
- 2025-03-10 20:57:14
@article{02aaad5b-0e69-4c84-89ca-38236137e9e1,
abstract = {{<p>The progression of keratoconus is commonly determined by comparing the results of corneal tomographic measurements on different occasions. However, investigations on the repeatability of measurements are commonly performed within the same day, thus not taking the inter-day variation into account. The effect of keratoconus disease severity on the measurement error is also seldom considered. In this post hoc investigation, the parameters A, B and C in the Belin ABCD Progression Display were evaluated in relation to disease severity in intra-day and inter-day measurements. Four consecutive measurements were performed on 61 patients with keratoconus on the same day (intra-day). In another cohort, four consecutive measurements were obtained and then repeated 3 days later in 25 patients with keratoconus and 25 healthy controls (inter-day). The results suggest that the diagnosis of disease progression would benefit from inter-day measurements, and the stratification of the parameters A and C according to disease severity. It is also recommended that tomographic systems such as the Pentacam HR be modified to allow the comparison of both single measurements and the mean of replicate measurements of the parameters used in the assessment of progression of keratoconus.</p>}},
author = {{Gustafsson, Ingemar and Faxén, Tove and Vicente, André and Bergström, Anders and Ivarsen, Anders and Hjortdal, Jesper Østergaard}},
issn = {{2045-2322}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{An inter-day assessment of the ABC parameters in the evaluation of progressive keratoconus}},
url = {{http://dx.doi.org/10.1038/s41598-021-95503-8}},
doi = {{10.1038/s41598-021-95503-8}},
volume = {{11}},
year = {{2021}},
}