Neural Suppression in Odor Recognition Memory
(2023) In Chemical Senses 48.- Abstract
Little is known about the neural basis of lower and higher-order olfactory functions such as odor memory, compared with other sensory systems. The aim of this study was to explore neural networks and correlates associated with three functions: passive smelling (PS), odor encoding (OE) and in particular odor recognition memory (ORM). Twenty-six healthy participants were examined using fMRI conducted across three sessions, one for each function. Independent component analysis revealed a difference between sessions where a distinct ORM component incorporating hippocampus and posterior cingulate showed delayed triggering dissociated from odor stimulation and recognition. By contrasting Hit for ORM (target odors correctly recognized as old)... (More)
Little is known about the neural basis of lower and higher-order olfactory functions such as odor memory, compared with other sensory systems. The aim of this study was to explore neural networks and correlates associated with three functions: passive smelling (PS), odor encoding (OE) and in particular odor recognition memory (ORM). Twenty-six healthy participants were examined using fMRI conducted across three sessions, one for each function. Independent component analysis revealed a difference between sessions where a distinct ORM component incorporating hippocampus and posterior cingulate showed delayed triggering dissociated from odor stimulation and recognition. By contrasting Hit for ORM (target odors correctly recognized as old) and a combination of PS and detected odors from OE, we found significantly lower activations in amygdala, piriform cortex, insula, thalamus, and the inferior parietal lobule. Region of interest analysis including anterior insula, posterior cingulate gyrus, dentate gyrus, left middle frontal gyrus, amygdala, and piriform cortex demonstrated that Hit were associated with lower activations compared with other memory responses. In summary, our findings suggest that successful recognition of familiar odors (odor familiarity) is associated with neural suppression in the above-mentioned regions of interest. Additionally, network including the hippocampus and posterior cingulate is engaged in a post-recognition process. This process may be related to incidental encoding of less familiar and more novel odors (odor novelty) and should be subject for future research.
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- author
- Eek, Tom ; Lundin, Fredrik ; Larsson, Maria ; Hamilton, Paul and Georgiopoulos, Charalampos LU
- organization
- publishing date
- 2023-01-28
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Chemical Senses
- volume
- 48
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85148678888
- pmid:36715106
- ISSN
- 1464-3553
- DOI
- 10.1093/chemse/bjad001
- language
- English
- LU publication?
- yes
- additional info
- © The Author(s) 2023. Published by Oxford University Press.
- id
- 02ecf99f-0eea-4e86-a518-4b59b6d8d6d8
- date added to LUP
- 2023-02-09 11:14:28
- date last changed
- 2024-04-29 02:01:56
@article{02ecf99f-0eea-4e86-a518-4b59b6d8d6d8,
abstract = {{<p>Little is known about the neural basis of lower and higher-order olfactory functions such as odor memory, compared with other sensory systems. The aim of this study was to explore neural networks and correlates associated with three functions: passive smelling (PS), odor encoding (OE) and in particular odor recognition memory (ORM). Twenty-six healthy participants were examined using fMRI conducted across three sessions, one for each function. Independent component analysis revealed a difference between sessions where a distinct ORM component incorporating hippocampus and posterior cingulate showed delayed triggering dissociated from odor stimulation and recognition. By contrasting Hit for ORM (target odors correctly recognized as old) and a combination of PS and detected odors from OE, we found significantly lower activations in amygdala, piriform cortex, insula, thalamus, and the inferior parietal lobule. Region of interest analysis including anterior insula, posterior cingulate gyrus, dentate gyrus, left middle frontal gyrus, amygdala, and piriform cortex demonstrated that Hit were associated with lower activations compared with other memory responses. In summary, our findings suggest that successful recognition of familiar odors (odor familiarity) is associated with neural suppression in the above-mentioned regions of interest. Additionally, network including the hippocampus and posterior cingulate is engaged in a post-recognition process. This process may be related to incidental encoding of less familiar and more novel odors (odor novelty) and should be subject for future research.</p>}},
author = {{Eek, Tom and Lundin, Fredrik and Larsson, Maria and Hamilton, Paul and Georgiopoulos, Charalampos}},
issn = {{1464-3553}},
language = {{eng}},
month = {{01}},
publisher = {{Oxford University Press}},
series = {{Chemical Senses}},
title = {{Neural Suppression in Odor Recognition Memory}},
url = {{http://dx.doi.org/10.1093/chemse/bjad001}},
doi = {{10.1093/chemse/bjad001}},
volume = {{48}},
year = {{2023}},
}